Identification and targeting of G-quadruplex structures in MALAT1 long non-coding RNA

The emerging structural complexity of G-quadruplex RNAs

(2021) Michael Banco et al.   RNA

Stochastic Collision Electrochemistry from Single G-Quadruplex/Hemin: Electrochemical Amplification and MicroRNA Sensing

(2021) Hao Wang et al.   ANALYTICAL CHEMISTRY

RNA G-quadruplexes (rG4s): genomics and biological functions

(2021) Kaixin Lyu et al.   NUCLEIC ACIDS RESEARCH

Biological relevance and therapeutic potential of G-quadruplex structures in the human noncoding transcriptome

(2021) Martina Tassinari et al.   NUCLEIC ACIDS RESEARCH

HOTAIRM1 Promotes Malignant Progression of Transformed Fibroblasts in Glioma Stem-Like Cells Remodeled Microenvironment via Regulating miR-133b-3p/TGFβ Axis

(2021) Haiyang Wang et al.   Frontiers in Oncology

Circular L-RNA aptamer promotes target recognition and controls gene activity

(2021) Danyang Ji et al.   NUCLEIC ACIDS RESEARCH

DNA G-quadruplex structures: more than simple roadblocks to transcription?

(2021) Jenna Robinson et al.   NUCLEIC ACIDS RESEARCH

Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

(2021) Gabrijela Dumbović et al.   Nature Communications

Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions

(2021) Xiaona Chen et al.   Nature Communications

Specific Binding of a d -RNA G-Quadruplex Structure with an l -RNA Aptamer

(2020) Chun-Yin Chan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

G-quadruplexes in mRNA: A key structure for biological function

(2020) Takuto Kamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms

(2020) Meredith Corley et al.   MOLECULAR CELL

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

(2020) Pauline Herviou et al.   Nature Communications

Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine–Peptide Conjugate

(2020) Yi-de He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

(2020) Raeann Goering et al.   eLife

Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability

(2020) Santi Mestre-Fos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer

(2020) Mubarak I Umar et al.   NUCLEIC ACIDS RESEARCH

Genomic amplification of long noncoding RNA HOTAIRM1 drives anaplastic thyroid cancer progression via repressing miR-144 biogenesis

(2020) Ling Zhang et al.   RNA Biology

The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression

(2020) Runliu Wu et al.   Cell Death & Disease

YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression

(2020) Lin Li et al.   Nature Chemical Biology

Gene regulation by long non-coding RNAs and its biological functions

(2020) Luisa Statello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction

(2019) Zhi-Yin Sun et al.   MOLECULES

G-Quadruplexes in Human Ribosomal RNA

(2019) Santi Mestre-Fos et al.   JOURNAL OF MOLECULAR BIOLOGY

MALAT1 regulates the transcriptional and translational levels of proto-oncogene RUNX2 in colorectal cancer metastasis

(2019) Qing Ji et al.   Cell Death & Disease

The diverse structural landscape of quadruplexes

(2019) Helen L. Lightfoot et al.   FEBS LETTERS

RNA structure drives interaction with proteins

(2019) Natalia Sanchez de Groot et al.   Nature Communications

DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

(2019) Markus Sauer et al.   Nature Communications

Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway

(2019) Tina Uroda et al.   MOLECULAR CELL

The role of RNA G‐quadruplexes in human diseases and therapeutic strategies

(2019) Prakash Kharel et al.   Wiley Interdisciplinary Reviews-RNA

MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches

(2018) Nicola Amodio et al.   Journal of Hematology & Oncology

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

(2018) Ka Lung Chan et al.   CHEMICAL COMMUNICATIONS

LncRNA DGCR5 represses the development of hepatocellular carcinoma by targeting the miR-346/KLF14 axis

(2018) Yu-Gang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches

(2018) Xingyang Qian et al.   TRENDS IN BIOCHEMICAL SCIENCES

A secondary structure within a human piRNA modulates its functionality

(2018) Sumirtha Balaratnam et al.   BIOCHIMIE

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

(2017) Huilin Huang et al.   GENES & DEVELOPMENT

Modulation of IGF2BP1 by long non-coding RNA HCG11 suppresses apoptosis of hepatocellular carcinoma cells via MAPK signaling transduction

(2017) Yantian Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Visualizing the secondary and tertiary architectural domains of lncRNA RepA

(2017) Fei Liu et al.   Nature Chemical Biology

3′ UTR G-quadruplexes regulate miRNA binding

(2017) Samuel Rouleau et al.   RNA

G-Quadruplexes: Prediction, Characterization, and Biological Application

(2017) Chun Kit Kwok et al.   TRENDS IN BIOTECHNOLOGY

Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

(2017) Shawn M. Lyons et al.   Nature Communications

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA

(2016) Chun Kit Kwok et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome

(2016) Chun Kit Kwok et al.   NATURE METHODS

Re-evaluation of G-quadruplex propensity with G4Hunter

(2016) Amina Bedrat et al.   NUCLEIC ACIDS RESEARCH

The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration

(2016) K Matsumura et al.   ONCOGENE

Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer

(2016) Yiwen Fang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

The RNA Stem–Loop to G-Quadruplex Equilibrium Controls Mature MicroRNA Production inside the Cell

(2015) Satyaprakash Pandey et al.   BIOCHEMISTRY

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing

(2015) Anastassios Vourekas et al.   GENES & DEVELOPMENT

HOTAIR Forms an Intricate and Modular Secondary Structure

(2015) Srinivas Somarowthu et al.   MOLECULAR CELL

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex

(2015) Brahim Heddi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

(2015) Palaniraja Thandapani et al.   eLife

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity

(2015) Emilio Cusanelli et al.   Frontiers in Genetics

Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex

(2015) Ezekiel Crenshaw et al.   PLoS One

Formation of a Stacked Dimeric G-Quadruplex Containing Bulges by the 5′-Terminal Region of Human Telomerase RNA (hTERC)

(2014) Herry Martadinata et al.   BIOCHEMISTRY

Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex

(2014) Q Ji et al.   BRITISH JOURNAL OF CANCER

The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites

(2014) Jason A. West et al.   MOLECULAR CELL

Thioflavin T as a fluorescence light-up probe for G4 formation

(2014) Amandine Renaud de la Faverie et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G quadruplex RNA structures in PSD-95 mRNA: potential regulators of miR-125a seed binding site accessibility

(2014) Snezana Stefanovic et al.   RNA

Effect of Loop Sequence and Loop Length on the Intrinsic Fluorescence of G-Quadruplexes

(2013) Chun Kit Kwok et al.   BIOCHEMISTRY

Long Noncoding RNAs: Past, Present, and Future

(2013) J. T. Y. Kung et al.   GENETICS

New scoring system to identify RNA G-quadruplex folding

(2013) J.-D. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening

(2013) Jean-Denis Beaudoin et al.   NUCLEIC ACIDS RESEARCH

An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2

(2012) Giulia Biffi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

(2012) E. P. Booy et al.   NUCLEIC ACIDS RESEARCH

Malat1 is not an essential component of nuclear speckles in mice

(2012) S. Nakagawa et al.   RNA

The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult

(2012) Bin Zhang et al.   Cell Reports

G–quadruplex RNA structure as a signal for neurite mRNA targeting

(2011) Murugan Subramanian et al.   EMBO REPORTS

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

(2011) Zhiqiang Zhang et al.   IMMUNITY

The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme

(2011) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

TheBCL-25′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression

(2010) Ramla Shahid et al.   BIOCHEMISTRY

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

(2010) Virginie Marcel et al.   CARCINOGENESIS

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

5'-UTR G-quadruplex structures acting as translational repressors

(2010) J.-D. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY