Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

(2021) Jennifer Gribble et al.   PLoS Pathogens

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity

(2021) Sheng Lin et al.   NUCLEIC ACIDS RESEARCH

Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme

(2021) Chang Liu et al.   SCIENCE

Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome

(2021) Weifan Xu et al.   Cell Reports

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

(2020) Liming Yan et al.   CELL

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

(2019) Natacha S. Ogando et al.   Frontiers in Microbiology

Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

(2019) Maria L. Agostini et al.   JOURNAL OF VIROLOGY

Epitranscriptomic marks: Emerging modulators of RNA virus gene expression

(2019) Rachel Netzband et al.   Wiley Interdisciplinary Reviews-RNA

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

m6A: Widespread regulatory control in virus replication

(2018) Oliver Manners et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

(2017) François Ferron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes

(2017) Clara C. Posthuma et al.   VIRUS RESEARCH

Ebselen, a useful tool for understanding cellular redox biology and a promising drug candidate for use in human diseases

(2016) Noriko Noguchi   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

(2016) Jack C Exell et al.   Nature Chemical Biology

Processing ribonucleotides incorporated during eukaryotic DNA replication

(2016) Jessica S. Williams et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1–XPF

(2015) Timothy M. Chapman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

(2015) Yuanyuan Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

(2014) Lorenzo Subissi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus

(2014) Marion Sevajol et al.   VIRUS RESEARCH

SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets

(2013) Lorenzo Subissi et al.   ANTIVIRAL RESEARCH

Density Functional Theory Study of the Attack of Ebselen on a Zinc-Finger Model

(2013) Sonia Antony et al.   INORGANIC CHEMISTRY

Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP

(2013) Xu Jin et al.   VIRUS RESEARCH

Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

(2013) Everett Clinton Smith et al.   PLoS Pathogens

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases

(2012) Blanka Sengerová et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

(2012) M. Bouvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coronaviruses

(2011) Mark R. Denison et al.   RNA Biology

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

(2010) S. Hare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

(2010) Mickaël Bouvet et al.   PLoS Pathogens

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

(2010) Lance D. Eckerle et al.   PLoS Pathogens

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)

(2009) Rok Sekirnik et al.   CHEMICAL COMMUNICATIONS

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein

(2008) Isabelle Imbert et al.   VIRUS RESEARCH