Necrostatin-1 Relieves Learning and Memory Deficits in a Zebrafish Model of Alzheimer’s Disease Induced by Aluminum

Longitudinal study of the effects of occupational aluminium exposure on workers’ cognition

(2021) Xiao-ting Lu et al.   CHEMOSPHERE

Reduced Cerebral Glucose Uptake in an Alzheimer’s Rat Model With Glucose-Weighted Chemical Exchange Saturation Transfer Imaging

(2021) Peidong Chen et al.   Frontiers in Aging Neuroscience

Relationship between the expression of TNFR1-RIP1/RIP3 in peripheral blood and cognitive function in occupational Al-exposed workers: A mediation effect study

(2021) Jingsi Zhang et al.   CHEMOSPHERE

Necroptosis: A Novel Pathway in Neuroinflammation

(2021) Ziyu Yu et al.   Frontiers in Pharmacology

Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway

(2020) Huan Li et al.   NEUROTOXICITY RESEARCH

Necrostatin-1 Mitigates Cognitive Dysfunction in Prediabetic Rats With no Alteration in Insulin Sensitivity

(2020) Kewarin Jinawong et al.   DIABETES

Nutritional supplementation of gallic acid ameliorates Alzheimer-type hippocampal neurodegeneration and cognitive impairment induced by aluminum chloride exposure in adult Wistar rats

(2020) B. Ogunlade et al.   DRUG AND CHEMICAL TOXICOLOGY

Camellia oil alleviates the progression of Alzheimer's disease in aluminum chloride-treated rats

(2020) Ming-Hong Weng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

(2020) Bart Tummers et al.   IMMUNITY

Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy

(2020) Sanae Miyake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Progressive impairment of learning and memory in adult zebrafish treated by Al2O3 nanoparticles when in embryos

(2020) Jin Chen et al.   CHEMOSPHERE

Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications

(2020) Liyuan Cao et al.   PHARMACOLOGICAL RESEARCH

Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway

(2019) Chunlei Yang et al.   Frontiers in Neuroscience

Aluminum in Neurological and Neurodegenerative Disease

(2019) Donald R. C. McLachlan et al.   MOLECULAR NEUROBIOLOGY

Mechanisms and regulation of aluminum-induced secretion of organic acid anions from plant roots

(2019) Jian-li Yang et al.   Journal of Zhejiang University-SCIENCE B

Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p

(2019) Ying Lin et al.   LIFE SCIENCES

Effects of Al Exposure on Mitochondrial Dynamics in Rat Hippocampus

(2019) Jisheng Nie et al.   NEUROTOXICITY RESEARCH

Aluminium in human brain tissue: how much is too much?

(2019) Christopher Exley et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Vinpocetine mitigates aluminum-induced cognitive impairment in socially isolated rats

(2019) Azza A. Ali et al.   PHYSIOLOGY & BEHAVIOR

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

(2019) Candice E. Van Skike et al.   AGING CELL

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Effects of Euterpe oleracea to Enhance Learning and Memory in a Conditioned Nicotinic and Muscarinic Receptor Response Paradigm by Modulation of Cholinergic Mechanisms in Rats

(2019) Cafer Yildirim et al.   JOURNAL OF MEDICINAL FOOD

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Aluminum-induced “mixed” cell death in mice cerebral tissue and potential intervention

(2019) Yan-xia Hao et al.   NEUROTOXICITY RESEARCH

Effects of Chronic Aluminum Lactate Exposure on Neuronal Apoptosis and Hippocampal Synaptic Plasticity in Rats

(2019) Xiujun Qin et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry

(2019) Masao Togao et al.   CHEMOSPHERE

Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test

(2019) Shuqin Wang et al.   TOXICON

Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease

(2018) Antonella Caccamo et al.   NEUROBIOLOGY OF AGING

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

(2018) Xuemei Chen et al.   Nature Communications

Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?

(2018) Lucija Tomljenovic   JOURNAL OF ALZHEIMERS DISEASE

Cerebral Microvascular Rather than Parenchymal Amyloid-β Protein Pathology Promotes Early Cognitive Impairment in Transgenic Mice

(2018) Wenjin Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer’s Disease

(2017) Asokan Prema et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus

(2017) Qing-Jiu Zhang et al.   MOLECULAR NEUROBIOLOGY

Necroptosis in neurodegenerative diseases: a potential therapeutic target

(2017) Shuo Zhang et al.   Cell Death & Disease

The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion

(2017) Liying Yang et al.   Experimental and Therapeutic Medicine

Is Necroptosis a Death Pathway in Aluminum-Induced Neuroblastoma Cell Demise?

(2017) Q.L. Zhang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Exploring Alzheimer's Disease in Zebrafish

(2017) Weiming Xia   JOURNAL OF ALZHEIMERS DISEASE

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

(2016) Seung‐Hoon Yang et al.   EMBO Molecular Medicine

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Higher brainBDNFgene expression is associated with slower cognitive decline in older adults

(2016) Aron S. Buchman et al.   NEUROLOGY

Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus

(2016) D.R. Sharma et al.   NEUROSCIENCE

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

(2016) Stephen C. Bondy   NEUROTOXICOLOGY

The Relationship Between Cognitive Impairment and Global DNA Methylation Decrease Among Aluminum Potroom Workers

(2015) Xiaojuan Yang et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Occupational Exposure to Aluminum and Alzheimer Disease

(2015) Sohaib A. Virk et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment

(2015) Sylvia Lombardo et al.   NEUROPHARMACOLOGY

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effects of a conventional photocoagulator and a 3-ns pulse laser on preconditioning responses and retinal ganglion cell survival after optic nerve crush

(2014) O'Sam Shibeeb et al.   EXPERIMENTAL EYE RESEARCH

Necroptosis, a novel type of programmed cell death, contributes to early neural cells damage after spinal cord injury in adult mice

(2014) Ming Liu et al.   JOURNAL OF SPINAL CORD MEDICINE

Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40

(2014) Xiaoyan Hu et al.   Molecular Neurodegeneration

Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat

(2014) Dai Cheng et al.   NEUROTOXICOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Soluble forms of tau are toxic in Alzheimer’s disease

(2012) Katherine Kopeikina et al.   Translational Neuroscience

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation

(2011) Annadora J. Bruce-Keller et al.   NEUROBIOLOGY OF DISEASE

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Memory loss in Alzheimer’s disease: implications for development of therapeutics

(2008) Carl A Gold et al.   Expert Review of Neurotherapeutics

Functional impairment in aged rats chronically exposed to human range dietary aluminum equivalents

(2008) J.R. Walton   NEUROTOXICOLOGY

Muscarinic acetylcholine receptors as CNS drug targets

(2007) Christopher J. Langmead et al.   PHARMACOLOGY & THERAPEUTICS