SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity

HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

(2021) Heesun Kim et al.   eLife

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

(2021) Stephen P. Methot et al.   NATURE CELL BIOLOGY

Histone H3K9 methylation promotes formation of genome compartments inCaenorhabditis elegansvia chromosome compaction and perinuclear anchoring

(2020) Qian Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

(2020) Leah Houri-Zeevi et al.   CELL

Elevated Temperatures Cause Transposon-Associated DNA Damage in C. elegans Spermatocytes

(2020) Nicole A. Kurhanewicz et al.   CURRENT BIOLOGY

Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3

(2020) Lianna Schwartz-Orbach et al.   eLife

Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression

(2020) Jan Padeken et al.   GENES & DEVELOPMENT

H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification

(2019) Dario Nicetto et al.   SCIENCE

A DNA repair protein and histone methyltransferase interact to promote genome stability in the Caenorhabditis elegans germ line

(2019) Bing Yang et al.   PLoS Genetics

Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65

(2019) Colin E. Delaney et al.   JOURNAL OF CELL BIOLOGY

Repression of Germline Genes in Caenorhabditis elegans Somatic Tissues by H3K9 Dimethylation of Their Promoters

(2019) Andreas Rechtsteiner et al.   GENETICS

Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression

(2019) Jan Padeken et al.   GENES & DEVELOPMENT

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

Essential roles of Windei and nuclear monoubiquitination of Eggless/ SETDB 1 in transposon silencing

(2019) Ken Osumi et al.   EMBO REPORTS

ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination

(2019) Takeshi Tsusaka et al.   EMBO REPORTS

In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene

(2019) Cyril J. Peter et al.   Nature Communications

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

(2018) Wenke Wang et al.   eLife

Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape

(2018) Paul Adrian Ginno et al.   Nature Communications

Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation inC. elegansembryos

(2018) Beste Mutlu et al.   Science Advances

H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression

(2018) S. P. Rowbotham et al.   Nature Communications

The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics

(2017) Lindsay K. Pino et al.   MASS SPECTROMETRY REVIEWS

Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans

(2017) Alexandre Paix et al.   METHODS

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

(2017) Kristel M. Dorighi et al.   MOLECULAR CELL

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Coordinated regulation of heterochromatin inheritance by Dpb3–Dpb4 complex

(2017) Haijin He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive single-cell transcriptional profiling of a multicellular organism

(2017) Junyue Cao et al.   SCIENCE

Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans

(2017) Natallia Kalinava et al.   Epigenetics & Chromatin

A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress

(2017) Alicia N McMurchy et al.   eLife

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability

(2016) Peter Zeller et al.   NATURE GENETICS

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

(2016) Richard T. Timms et al.   Cell Reports

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Repeat DNA in genome organization and stability

(2015) Jan Padeken et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

QuasR: quantification and annotation of short reads in R

(2014) Dimos Gaidatzis et al.   BIOINFORMATICS

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

HP1α mediates defective heterochromatin repair and accelerates senescence inZmpste24-deficient cells

(2014) Jia Liu et al.   CELL CYCLE

Nucleolus and nuclear periphery: Velcro for heterochromatin

(2014) Jan Padeken et al.   CURRENT OPINION IN CELL BIOLOGY

Defining heterochromatin inC. elegansthrough genome-wide analysis of the heterochromatin protein 1 homolog HPL-2

(2014) Jacob M. Garrigues et al.   GENOME RESEARCH

Specificity, propagation, and memory of pericentric heterochromatin

(2014) K. Muller-Ott et al.   Molecular Systems Biology

Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe

(2014) Takeshi Mizuguchi et al.   NATURE

SPR-5 and MET-2 function cooperatively to reestablish an epigenetic ground state during passage through the germ line

(2014) Shana C. Kerr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

(2014) Eric L. Greer et al.   Cell Reports

Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast

(2013) Benjamin J Alper et al.   EMBO JOURNAL

Nano-scale analyses of the chromatin decompaction induced by histone acetylation

(2012) Kohji Hizume et al.   ARCHIVES OF HISTOLOGY AND CYTOLOGY

Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery

(2012) Benjamin D. Towbin et al.   CELL

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

(2012) Caryn S. Ross-Innes et al.   NATURE

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

Global analysis of DNA methylation and transcription of human repetitive sequences.

(2010) Béatrice Horard et al.   Epigenetics

The spatial dynamics of tissue-specific promoters during C. elegans development

(2010) P. Meister et al.   GENES & DEVELOPMENT

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Localization and Independent Acquisition of the H3K9me2 and H3K9me3 Chromatin Modifications in the Caenorhabditis elegans Adult Germ Line

(2010) Jessica B. Bessler et al.   PLoS Genetics

Windei, the Drosophila Homolog of mAM/MCAF1, Is an Essential Cofactor of the H3K9 Methyl Transferase dSETDB1/Eggless in Germ Line Development

(2009) Carmen M. Koch et al.   PLoS Genetics

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

(2008) Makoto Tachibana et al.   EMBO JOURNAL