标题
The potential of mitochondrial genome engineering
作者
关键词
-
出版物
NATURE REVIEWS GENETICS
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-12-02
DOI
10.1038/s41576-021-00432-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- An atlas of mitochondrial DNA genotype–phenotype associations in the UK Biobank
- (2021) Ekaterina Yonova-Doing et al. NATURE GENETICS
- Mitochondrial disease in adults: recent advances and future promise
- (2021) Yi Shiau Ng et al. LANCET NEUROLOGY
- Biparental inheritance of mitochondrial DNA revisited
- (2021) Alistair T. Pagnamenta et al. NATURE REVIEWS GENETICS
- MitoPhen database: a human phenotype ontology-based approach to identify mitochondrial DNA diseases
- (2021) Thiloka E Ratnaike et al. NUCLEIC ACIDS RESEARCH
- Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
- (2021) Ugne Zekonyte et al. Nature Communications
- Mitochondrial Diseases: Hope for the Future
- (2020) Oliver M. Russell et al. CELL
- Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective
- (2020) Christopher B. Jackson et al. TRENDS IN MOLECULAR MEDICINE
- A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing
- (2020) Beverly Y. Mok et al. NATURE
- Mammalian mitochondrial DNA replication and mechanisms of deletion formation
- (2020) Maria Falkenberg et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Mitochondrial transplantation—a possible therapeutic for mitochondrial dysfunction?
- (2020) Robert N Lightowlers et al. EMBO REPORTS
- Current Progress with Mammalian Models of Mitochondrial DNA Disease
- (2020) James Bruce Stewart JOURNAL OF INHERITED METABOLIC DISEASE
- Extreme heterogeneity of human mitochondrial DNA from organelles to populations
- (2020) James B. Stewart et al. NATURE REVIEWS GENETICS
- Elimination of mutant mtDNA by an optimized mpTALEN restores differentiation capacities of heteroplasmic MELAS-iPSCs
- (2020) Naoki Yahata et al. Molecular Therapy-Methods & Clinical Development
- Mitochondrial DNA copy number in human disease: the more the better?
- (2020) Roberta Filograna et al. FEBS LETTERS
- Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates
- (2020) Alexander N. Patananan et al. Cell Reports
- Mitochondrial proteins: from biogenesis to functional networks
- (2019) Nikolaus Pfanner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
- (2019) Örjan Persson et al. Nature Communications
- Adeno-associated virus vector as a platform for gene therapy delivery
- (2019) Dan Wang et al. NATURE REVIEWS DRUG DISCOVERY
- Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
- (2019) R. Filograna et al. Science Advances
- G-Quadruplex Mediated Reduction of a Pathogenic Mitochondrial Heteroplasmy
- (2019) Mansur M Naeem et al. HUMAN MOLECULAR GENETICS
- Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
- (2019) Simonetta Andreazza et al. Nature Communications
- Mitochondria as multifaceted regulators of cell death
- (2019) Florian J. Bock et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
- (2018) Claudia V Pereira et al. EMBO Molecular Medicine
- The mitochondrial DNA genetic bottleneck: inheritance and beyond
- (2018) Haixin Zhang et al. Essays in Biochemistry
- NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
- (2018) Edoardo Gaude et al. MOLECULAR CELL
- Progress in mitochondrial replacement therapies
- (2018) Mary Herbert et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice
- (2018) Johanna H K Kauppila et al. NUCLEIC ACIDS RESEARCH
- Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner
- (2018) Romuald Loutre et al. PLoS One
- Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized
- (2018) Payam A. Gammage et al. TRENDS IN GENETICS
- Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
- (2018) Viktoriya Peeva et al. Nature Communications
- The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
- (2018) Nadee Nissanka et al. Nature Communications
- Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs
- (2018) Yi Yang et al. Protein & Cell
- Phenotypic heterogeneity in m.3243A>G mitochondrial disease: The role of nuclear factors
- (2018) Sarah J. Pickett et al. Annals of Clinical and Translational Neurology
- MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation
- (2018) Sandra R. Bacman et al. NATURE MEDICINE
- Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo
- (2018) Payam A. Gammage et al. NATURE MEDICINE
- Biparental Inheritance of Mitochondrial DNA in Humans
- (2018) Shiyu Luo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ
- (2018) Colby L. Samstag et al. PLoS Genetics
- Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
- (2017) Aaron F. Phillips et al. MOLECULAR CELL
- Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
- (2017) Nicole M. Gaudelli et al. NATURE
- Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells
- (2017) Dipali Patel et al. Scientific Reports
- Maintenance and Expression of Mammalian Mitochondrial DNA
- (2016) Claes M. Gustafsson et al. Annual Review of Biochemistry
- Modifying the Mitochondrial Genome
- (2016) Alexander N. Patananan et al. Cell Metabolism
- Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells
- (2016) Ting-Hsiang Wu et al. Cell Metabolism
- Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease
- (2016) Louise A. Hyslop et al. NATURE
- Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
- (2016) Eunju Kang et al. NATURE
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Mitochondrial DNA exhibits resistance to induced point and deletion mutations
- (2016) William J. Valente et al. NUCLEIC ACIDS RESEARCH
- Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs
- (2016) Payam A. Gammage et al. NUCLEIC ACIDS RESEARCH
- Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
- (2016) Nikolay P. Kandul et al. Nature Communications
- A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease
- (2016) Johanna H.K. Kauppila et al. Cell Reports
- Mitochondrial diseases
- (2016) Gráinne S. Gorman et al. Nature Reviews Disease Primers
- Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease
- (2015) Gráinne S. Gorman et al. ANNALS OF NEUROLOGY
- Leigh syndrome: One disorder, more than 75 monogenic causes
- (2015) Nicole J. Lake et al. ANNALS OF NEUROLOGY
- Mitochondrial DNA copy number differentiates the Leber’s hereditary optic neuropathy affected individuals from the unaffected mutation carriers
- (2015) Angelica Bianco et al. BRAIN
- Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing
- (2015) Pradeep Reddy et al. CELL
- Base Excision Repair in the Mitochondria
- (2015) Aishwarya Prakash et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases
- (2015) Masami Hashimoto et al. MOLECULAR THERAPY
- A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions
- (2015) Rafik Z. Fayzulin et al. NUCLEIC ACIDS RESEARCH
- Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies
- (2015) Ana Bratic et al. Nature Communications
- Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations
- (2014) P. A. Gammage et al. EMBO Molecular Medicine
- In D-loop: 40years of mitochondrial 7S DNA
- (2014) Thomas J. Nicholls et al. EXPERIMENTAL GERONTOLOGY
- MRI in Leber's hereditary optic neuropathy: the relationship to multiple sclerosis
- (2014) Lucy Matthews et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication
- (2014) Javier Miralles Fusté et al. PLoS Genetics
- Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy
- (2013) Carla Giordano et al. BRAIN
- Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs
- (2013) Sandra R Bacman et al. NATURE MEDICINE
- No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline
- (2013) E. Hagstrom et al. NUCLEIC ACIDS RESEARCH
- Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage
- (2013) Scott R. Kennedy et al. PLoS Genetics
- Targeted DNA excision in Arabidopsis by a re-engineered homing endonuclease
- (2012) Mauricio S Antunes et al. BMC BIOTECHNOLOGY
- Minimizing the damage: repair pathways keep mitochondrial DNA intact
- (2012) Lawrence Kazak et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mouse mtDNA mutant model of Leber hereditary optic neuropathy
- (2012) C. S. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model
- (2012) H. Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter
- (2011) Yuma Yamada et al. BIOMATERIALS
- Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease
- (2011) S R Bacman et al. GENE THERAPY
- The Lower Bound to the Evolution of Mutation Rates
- (2011) Michael Lynch Genome Biology and Evolution
- Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
- (2010) M. Christian et al. GENETICS
- A neurological perspective on mitochondrial disease
- (2010) Robert McFarland et al. LANCET NEUROLOGY
- Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication
- (2010) Javier Miralles Fusté et al. MOLECULAR CELL
- Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures
- (2010) Yannick Doyon et al. NATURE METHODS
- Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA
- (2010) Michal Minczuk et al. Nature Protocols
- Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
- (2010) D.-F. Suen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy
- (2010) S. Arnould et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Gene–environment interactions in Leber hereditary optic neuropathy
- (2009) Matthew Anthony Kirkman et al. BRAIN
- Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks
- (2009) S. R. Bacman et al. NUCLEIC ACIDS RESEARCH
- A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
- (2008) David J. Pagliarini et al. CELL
- Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes
- (2008) M F Alexeyev et al. GENE THERAPY
- A functionally dominant mitochondrial DNA mutation
- (2008) S. Sacconi et al. HUMAN MOLECULAR GENETICS
- Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA
- (2008) Michal Minczuk et al. NUCLEIC ACIDS RESEARCH
- Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes
- (2008) H. Xu et al. SCIENCE
- A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations
- (2008) Weiwei Fan et al. SCIENCE
- The m.5650G>A mitochondrial tRNAAla mutation is pathogenic and causes a phenotype of pure myopathy
- (2007) Robert McFarland et al. NEUROMUSCULAR DISORDERS
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