Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport

Architecture of the membrane-bound cytochrome c heme lyase CcmF

(2021) Anton Brausemann et al.   Nature Chemical Biology

In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases

(2021) Molly C Sutherland et al.   eLife

Handling heme with care

(2021) Breann L. Brown et al.   Nature Chemical Biology

Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

(2020) L. M. Schiffmann et al.   Nature Communications

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

(2020) Ali Punjani et al.   NATURE METHODS

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

PGRMC2 is an intracellular haem chaperone critical for adipocyte function

(2019) Andrea Galmozzi et al.   NATURE

Structurally Mapping Endogenous Heme in the CcmCDE Membrane Complex for Cytochrome c Biogenesis

(2018) Molly C. Sutherland et al.   JOURNAL OF MOLECULAR BIOLOGY

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

(2018) Tristan Ian Croll   Acta Crystallographica Section D-Structural Biology

A mosaic form of microphthalmia with linear skin defects

(2018) Nina Prepeluh et al.   BMC Pediatrics

Handling heme: The mechanisms underlying the movement of heme within and between cells

(2018) Rebecca K. Donegan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase

(2018) Molly C. Sutherland et al.   mBio

Inter-organ regulation of haem homeostasis

(2017) Jason N. Pitt et al.   NATURE CELL BIOLOGY

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Do Mammalian Cells Really Need to Export and Import Heme?

(2017) Prem Ponka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quantification of Detergents Complexed with Membrane Proteins

(2017) Vincent Chaptal et al.   Scientific Reports

Heme Mobilization in Animals: A Metallolipid’s Journey

(2016) Amit R. Reddi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Protein export through the bacterial Sec pathway

(2016) Alexandra Tsirigotaki et al.   NATURE REVIEWS MICROBIOLOGY

Regulation of intracellular heme trafficking revealed by subcellular reporters

(2016) Xiaojing Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors

(2016) David A. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of bacterial haem importer complex in the inward-facing conformation

(2016) Youichi Naoe et al.   Nature Communications

Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception

(2016) Deborah Chiabrando et al.   PLoS Genetics

Alteration of heme metabolism in a cellular model of Diamond-Blackfan anemia

(2015) Sonia Mercurio et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Identification of the Mitochondrial Heme Metabolism Complex

(2015) Amy E. Medlock et al.   PLoS One

Cytochrome c biogenesis System I: An intricate process catalyzed by a maturase supercomplex?

(2014) Andreia F. Verissimo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Variation of the Detergent-Binding Capacity and Phospholipid Content of Membrane Proteins When Purified in Different Detergents

(2014) Hüseyin Ilgü et al.   BIOPHYSICAL JOURNAL

The CcmFH complex is the system I holocytochromecsynthetase: engineering cytochromecmaturation independent of CcmABCDE

(2014) Brian San Francisco et al.   MOLECULAR MICROBIOLOGY

Interaction of HoloCcmE with CcmF in Heme Trafficking and Cytochrome c Biosynthesis

(2013) Brian San Francisco et al.   JOURNAL OF MOLECULAR BIOLOGY

X-ray structure of the Yersinia pestis heme transporter HmuUV

(2012) Jae-Sung Woo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thiol redox requirements and substrate specificities of recombinant cytochrome c assembly systems II and III

(2011) Cynthia L. Richard-Fogal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Composition and function of cytochrome c biogenesis System II

(2011) Jörg Simon et al.   FEBS Journal

Comparing substrate specificity between cytochrome c maturation and cytochrome c heme lyase systems for cytochrome c biogenesis

(2011) Jesse G. Kleingardner et al.   Metallomics

A conserved haem redox and trafficking pathway for cofactor attachment

(2009) Cynthia L Richard-Fogal et al.   EMBO JOURNAL

Cytochrome c Biogenesis: Mechanisms for Covalent Modifications and Trafficking of Heme and for Heme-Iron Redox Control

(2009) R. G. Kranz et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

His protects heme as it crosses the membrane

(2009) S. S. Merchant   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CcsBA is a cytochrome c synthetase that also functions in heme transport

(2009) E. R. Frawley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE