A synthetic antibiotic class overcoming bacterial multidrug resistance

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance

(2021) Maxim S. Svetlov et al.   Nature Chemical Biology

Discovery of Macrolide Antibiotics Effective against Multi-Drug Resistant Gram-Negative Pathogens

(2021) Andrew G. Myers et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Practical, Component-Based Synthetic Route to Methylthiolincosamine Permitting Facile Northern-Half Diversification of Lincosamide Antibiotics

(2021) Matthew J. Mitcheltree et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical Gram-Scale Synthesis of Iboxamycin, a Potent Antibiotic Candidate

(2021) Jeremy D. Mason et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

(2021) Caillan Crowe-McAuliffe et al.   Nature Communications

Investigation of Antibiotic Resistance, Serotype Distribution, and Genetic Characteristics of 164 Invasive Streptococcus pneumoniae from North China Between April 2016 and October 2017

(2020) Chunjiang Zhao et al.   Infection and Drug Resistance

Characterization of compound A, a novel lincomycin derivative active against methicillin-resistant Staphylococcus aureus

(2020) Yoko Hirai et al.   JOURNAL OF ANTIBIOTICS

Synthetic group A streptogramin antibiotics that overcome Vat resistance

(2020) Qi Li et al.   NATURE

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network, 2015–2017

(2019) Lindsey M. Weiner-Lastinger et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

(2018) Jinzhong Lin et al.   Annual Review of Biochemistry

Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest

(2018) Victoriia Murina et al.   NUCLEIC ACIDS RESEARCH

Optimized arylomycins are a new class of Gram-negative antibiotics

(2018) Peter A. Smith et al.   NATURE

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

A platform for the discovery of new macrolide antibiotics

(2016) Ian B. Seiple et al.   NATURE

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stereocontrolled Synthesis ofsyn-β-Hydroxy-α-Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide

(2014) Ian B. Seiple et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery

(2014) Peter M. Wright et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

(2014) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regioselective Wacker Oxidation of Internal Alkenes: Rapid Access to Functionalized Ketones Facilitated by Cross-Metathesis

(2013) Bill Morandi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tools for Characterizing Bacterial Protein Synthesis Inhibitors

(2013) Cédric Orelle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

(2013) Cédric Orelle et al.   NUCLEIC ACIDS RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

(2010) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) A. M. B. Giessing et al.   RNA

Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis Inhibitors

(2008) L. K. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY