The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

Systematic Assessment of the Accuracy of Subunit Counting in Biomolecular Complexes Using Automated Single-Molecule Brightness Analysis

(2022) John S. H. Danial et al.   Journal of Physical Chemistry Letters

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

(2020) Tomomi Kuwana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

(2020) Sweta Iyer et al.   Cell Death & Disease

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

(2020) Takahiro Yamazaki et al.   NATURE IMMUNOLOGY

Apoptotic mitochondria prime anti-tumour immunity

(2020) Kate McArthur et al.   Cell Death Discovery

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

(2019) Nicholas R Ader et al.   eLife

Quantitative analysis of super-resolved structures using ASAP

(2019) John S. H. Danial et al.   NATURE METHODS

Nuclear pores as versatile reference standards for quantitative superresolution microscopy

(2019) Jervis Vermal Thevathasan et al.   NATURE METHODS

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

(2019) Mark F. van Delft et al.   Nature Chemical Biology

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

VDAC2 enables BAX to mediate apoptosis and limit tumor development

(2018) Hui San Chin et al.   Nature Communications

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

(2017) Evangelos Giampazolias et al.   NATURE CELL BIOLOGY

Bax and Bak Pores: Are We Closing the Circle?

(2017) Katia Cosentino et al.   TRENDS IN CELL BIOLOGY

Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis

(2017) Margaret E. Maes et al.   PLoS One

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

A method for detergent-free isolation of membrane proteins in their local lipid environment

(2016) Sarah C Lee et al.   Nature Protocols

In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy

(2016) Yusuke Nasu et al.   Scientific Reports

A Set of Homo-Oligomeric Standards Allows Accurate Protein Counting

(2015) Kieran Finan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An interconnected hierarchical model of cell death regulation by the BCL-2 family

(2015) Hui-Chen Chen et al.   NATURE CELL BIOLOGY

Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange

(2015) Yidan Ding et al.   NATURE METHODS

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

(2015) Yamunadevi Subburaj et al.   Nature Communications

Automated analysis of giant unilamellar vesicles using circular Hough transformation

(2014) Eduard Hermann et al.   BIOINFORMATICS

ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging

(2014) Martin Ovesný et al.   BIOINFORMATICS

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

(2014) S B Ma et al.   CELL DEATH AND DIFFERENTIATION

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Mechanistic Differences in the Membrane Activity of Bax and Bcl-xL Correlate with Their Opposing Roles in Apoptosis

(2013) Stephanie Bleicken et al.   BIOPHYSICAL JOURNAL

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

(2013) D Westphal et al.   CELL DEATH AND DIFFERENTIATION

Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size

(2013) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

(2013) Barbara Schellenberg et al.   MOLECULAR CELL

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct activation of full-length proapoptotic BAK

(2013) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion

(2009) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis

(2008) L. Zhou et al.   JOURNAL OF CELL SCIENCE