Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

(2019) Michael A. Dengler et al.   Cell Reports

BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL

(2018) Hector Flores-Romero et al.   CELL DEATH AND DIFFERENTIATION

VDAC2-specific cellular functions and the underlying structure

(2016) Shamim Naghdi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway

(2016) Thomas P. Garner et al.   MOLECULAR CELL

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes

(2016) Vicente Andreu-Fernández et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pro-apoptotic Bax molecules densely populate the edges of membrane pores

(2016) Tomomi Kuwana et al.   Scientific Reports

The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation

(2016) Joachim Lauterwasser et al.   Scientific Reports

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

(2015) Z. Zhang et al.   EMBO JOURNAL

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes

(2015) Laura A Gillies et al.   MOLECULAR BIOLOGY OF THE CELL

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

(2015) Yamunadevi Subburaj et al.   Nature Communications

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

(2014) S B Ma et al.   CELL DEATH AND DIFFERENTIATION

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Apoptosis Regulation at the Mitochondrial Outer Membrane

(2013) Laura A. Gillies et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

(2013) Barbara Schellenberg et al.   MOLECULAR CELL

Three-dimensional structure of Bax-mediated pores in membrane bilayers

(2013) X-P Xu et al.   Cell Death & Disease

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria

(2012) F Todt et al.   CELL DEATH AND DIFFERENTIATION

Direct and selective small-molecule activation of proapoptotic BAX

(2012) Evripidis Gavathiotis et al.   Nature Chemical Biology

Bax Activation Initiates the Assembly of a Multimeric Catalyst that Facilitates Bax Pore Formation in Mitochondrial Outer Membranes

(2012) Yulia Kushnareva et al.   PLOS BIOLOGY

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

(2011) G Dewson et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor

(2010) Michael Lazarou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation

(2009) Blanca Schafer et al.   MOLECULAR BIOLOGY OF THE CELL

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

(2008) Lieven P Billen et al.   PLOS BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY