Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

Lineage tracing of human development through somatic mutations

(2021) Michael Spencer Chapman et al.   NATURE

Germline risk of clonal haematopoiesis

(2021) Alexander J. Silver et al.   NATURE REVIEWS GENETICS

Single-cell analysis based dissection of clonality in myelofibrosis

(2020) Elena Mylonas et al.   Nature Communications

DNA methylation disruption reshapes the hematopoietic differentiation landscape

(2020) Franco Izzo et al.   NATURE GENETICS

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness

(2020) Elizabeth L. Ostrander et al.   Stem Cell Reports

Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions

(2020) Leanna Morinishi et al.   Cell Systems

Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients

(2019) Friederike Christen et al.   BLOOD

Lineage restriction analyses in CHIP indicate myeloid bias forTET2and multipotent stem cell origin forDNMT3A

(2018) Manuel Buscarlet et al.   BLOOD

Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis

(2018) Christopher Maximilian Arends et al.   LEUKEMIA

Decoding non-random mutational signatures at Cas9 targeted sites

(2018) Amir Taheri-Ghahfarokhi et al.   NUCLEIC ACIDS RESEARCH

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

(2018) Mira Jeong et al.   Cell Reports

Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

(2018) Lorenzo Brunetti et al.   Jove-Journal of Visualized Experiments

Prediction of acute myeloid leukaemia risk in healthy individuals

(2018) Sagi Abelson et al.   NATURE

Population dynamics of normal human blood inferred from somatic mutations

(2018) Henry Lee-Six et al.   NATURE

A universal SNP and small-indel variant caller using deep neural networks

(2018) Ryan Poplin et al.   NATURE BIOTECHNOLOGY

Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation

(2018) Mareike Frick et al.   JOURNAL OF CLINICAL ONCOLOGY

Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6

(2017) Rasmus O Bak et al.   eLife

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

(2016) Xiaotian Zhang et al.   NATURE GENETICS

Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

(2016) Michael C. Gundry et al.   Cell Reports

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Loss ofTET2in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

(2015) Kasper D. Rasmussen et al.   GENES & DEVELOPMENT

Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells

(2015) O A Guryanova et al.   LEUKEMIA

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

(2015) Britta Will et al.   NATURE MEDICINE

TET2mutations in cytogenetically normal acute myeloid leukemia: Clinical implications and evolutionary patterns

(2014) Frederik Damm et al.   GENES CHROMOSOMES & CANCER

Targeted genome editing in human repopulating haematopoietic stem cells

(2014) Pietro Genovese et al.   NATURE

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquired Initiating Mutations in Early Hematopoietic Cells of CLL Patients

(2014) F. Damm et al.   Cancer Discovery

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

(2013) J. Wang et al.   BLOOD

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome

(2012) S Schnittger et al.   LEUKEMIA

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

(2011) E. Pronier et al.   BLOOD

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

(2011) Cyril Quivoron et al.   CANCER CELL

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Prognostic Significance of ASXL1 Mutations in Patients With Myelodysplastic Syndromes

(2011) Felicitas Thol et al.   JOURNAL OF CLINICAL ONCOLOGY

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

(2011) M. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

(2010) Myunggon Ko et al.   NATURE

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

(2009) C. L. Fisher et al.   BLOOD