标题
DNA methylation disruption reshapes the hematopoietic differentiation landscape
作者
关键词
-
出版物
NATURE GENETICS
Volume 52, Issue 4, Pages 378-387
出版商
Springer Science and Business Media LLC
发表日期
2020-03-24
DOI
10.1038/s41588-020-0595-4
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The cis-Regulatory Atlas of the Mouse Immune System
- (2019) Hideyuki Yoshida et al. CELL
- Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia
- (2019) Federico Gaiti et al. NATURE
- Somatic mutations and cell identity linked by Genotyping of Transcriptomes
- (2019) Anna S. Nam et al. NATURE
- Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy
- (2019) Jerome C. Martin et al. CELL
- Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
- (2019) Max Emperle et al. NUCLEIC ACIDS RESEARCH
- Mapping the Mouse Cell Atlas by Microwell-Seq
- (2018) Xiaoping Han et al. CELL
- Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis
- (2018) Amir Giladi et al. NATURE CELL BIOLOGY
- Enhanced Anti-Leukemic Effects through Induction of Immunomodulating Microenvironment by Blocking CXCR4 and PD-L1 in an AML Mouse Model
- (2018) Hee-Sun Hwang et al. IMMUNOLOGICAL INVESTIGATIONS
- Prediction of acute myeloid leukaemia risk in healthy individuals
- (2018) Sagi Abelson et al. NATURE
- Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes
- (2017) Alberto Yáñez et al. IMMUNITY
- Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C − Cells
- (2017) Alexander Mildner et al. IMMUNITY
- Dnmt3a regulates T-cell development and suppresses T-ALL transformation
- (2017) A C Kramer et al. LEUKEMIA
- Human haematopoietic stem cell lineage commitment is a continuous process
- (2017) Lars Velten et al. NATURE CELL BIOLOGY
- chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
- (2017) Alicia N Schep et al. NATURE METHODS
- SCENIC: single-cell regulatory network inference and clustering
- (2017) Sara Aibar et al. NATURE METHODS
- Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
- (2017) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis
- (2017) Ivan V Kulakovskiy et al. NUCLEIC ACIDS RESEARCH
- Impact of cytosine methylation on DNA binding specificities of human transcription factors
- (2017) Yimeng Yin et al. SCIENCE
- Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2 - and TET2 -Mutant Acute Myeloid Leukemia
- (2017) Alan H. Shih et al. Cancer Discovery
- Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes
- (2017) Judith F. Kribelbauer et al. Cell Reports
- Targeting the CXCL12/CXCR4 axis in acute myeloid leukemia: from bench to bedside
- (2017) Byung-Sik Cho et al. KOREAN JOURNAL OF INTERNAL MEDICINE
- DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias
- (2016) Liubin Yang et al. CANCER CELL
- Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
- (2016) Paul W. Tetteh et al. Cell Stem Cell
- Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
- (2016) Andre Olsson et al. NATURE
- Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
- (2016) Katherine C. Verbist et al. NATURE
- DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
- (2016) Xiaotian Zhang et al. NATURE GENETICS
- Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing
- (2016) Roy Drissen et al. NATURE IMMUNOLOGY
- Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
- (2016) Maxim V. Kuleshov et al. NUCLEIC ACIDS RESEARCH
- Tissue-specific DNA demethylation is required for proper B-cell differentiation and function
- (2016) Shari Orlanski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamics of epigenetic regulation at the single-cell level
- (2016) L. Bintu et al. SCIENCE
- Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
- (2015) D. P. Steensma et al. BLOOD
- Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
- (2015) Franziska Paul et al. CELL
- Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
- (2015) Evan Z. Macosko et al. CELL
- Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations
- (2015) Nicola K. Wilson et al. Cell Stem Cell
- Competition between DNA methylation and transcription factors determines binding of NRF1
- (2015) Silvia Domcke et al. NATURE
- G&T-seq: parallel sequencing of single-cell genomes and transcriptomes
- (2015) Iain C Macaulay et al. NATURE METHODS
- Clonal Hematopoiesis and Blood-Cancer Risk
- (2015) NEW ENGLAND JOURNAL OF MEDICINE
- Tet2-mutated myeloid progenitors possess aberrant in vitro self-renewal capacity
- (2014) H. Kunimoto et al. BLOOD
- Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
- (2014) A. Mayle et al. BLOOD
- DNMT3Amutations and prognostic significance in childhood acute lymphoblastic leukemia
- (2014) Weijing Li et al. LEUKEMIA & LYMPHOMA
- Full-length RNA-seq from single cells using Smart-seq2
- (2014) Simone Picelli et al. Nature Protocols
- Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
- (2014) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes
- (2014) Mario Pujato et al. NUCLEIC ACIDS RESEARCH
- Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
- (2013) O. Abdel-Wahab et al. BLOOD
- Mutational heterogeneity in cancer and the search for new cancer-associated genes
- (2013) Michael S. Lawrence et al. NATURE
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- GENCODE: The reference human genome annotation for The ENCODE Project
- (2012) J. Harrow et al. GENOME RESEARCH
- DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells
- (2012) Christoph Bock et al. MOLECULAR CELL
- The accessible chromatin landscape of the human genome
- (2012) Robert E. Thurman et al. NATURE
- Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
- (2012) Lambert Busque et al. NATURE GENETICS
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- TET2andDNMT3AMutations in Human T-Cell Lymphoma
- (2012) Lucile Couronné et al. NEW ENGLAND JOURNAL OF MEDICINE
- methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
- (2012) Altuna Akalin et al. GENOME BIOLOGY
- Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications
- (2011) Felix Krueger et al. BIOINFORMATICS
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
- (2011) Kelly Moran-Crusio et al. CANCER CELL
- Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression
- (2010) Y.-S. Tzeng et al. BLOOD
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
- (2010) Stefan Gross et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Comprehensive methylome map of lineage commitment from haematopoietic progenitors
- (2010) Hong Ji et al. NATURE
- DNMT3AMutations in Acute Myeloid Leukemia
- (2010) Timothy J. Ley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutation inTET2in Myeloid Cancers
- (2009) François Delhommeau et al. NEW ENGLAND JOURNAL OF MEDICINE
- Generalized linear mixed models: a practical guide for ecology and evolution
- (2009) Benjamin M. Bolker et al. TRENDS IN ECOLOGY & EVOLUTION
- Heterogeneity of Embryonic and Adult Stem Cells
- (2008) Thomas Graf et al. Cell Stem Cell
- Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
- (2008) Hannah H. Chang et al. NATURE
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