Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities

Pan-cancer transcriptomic predictors of perineural invasion improve occult histopathological detection

(2021) Jimmy A Guo et al.   CLINICAL CANCER RESEARCH

Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma

(2021) Kruttika Bhat et al.   JNCI-Journal of the National Cancer Institute

Long‐Term Safety and Efficacy of Subcutaneous Tanezumab Versus Nonsteroidal Antiinflammatory Drugs for Hip or Knee Osteoarthritis: A Randomized Trial

(2021) Marc C. Hochberg et al.   Arthritis & Rheumatology

Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma

(2021) Matthias Schneider et al.   NEURO-ONCOLOGY

NF1 mutation drives neuronal activity-dependent initiation of optic glioma

(2021) Yuan Pan et al.   NATURE

ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases

(2020) Priya Kumthekar et al.   CLINICAL CANCER RESEARCH

The Neuroimmune Axis in the Tumor Microenvironment

(2020) Michael R. Shurin et al.   JOURNAL OF IMMUNOLOGY

Peripheral T cell expansion predicts tumour infiltration and clinical response

(2020) Thomas D. Wu et al.   NATURE

PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

(2020) Kwanha Yu et al.   NATURE

Cancer–neuronal crosstalk and the startups working to silence it

(2020) Elie Dolgin   NATURE BIOTECHNOLOGY

Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo

(2020) Alexander M. M. Eggermont et al.   JAMA Oncology

Roadmap for the Emerging Field of Cancer Neuroscience

(2020) Michelle Monje et al.   CELL

Clinicopathologic and molecular characterization of NTRK-rearranged thyroid carcinoma (NRTC)

(2020) Ying-Hsia Chu et al.   MODERN PATHOLOGY

Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner

(2020) Casey J. Latario et al.   MOLECULAR BIOLOGY OF THE CELL

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update

(2020) Charles L. Loprinzi et al.   JOURNAL OF CLINICAL ONCOLOGY

GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential

(2019) Lois M. Mulligan   Frontiers in Physiology

AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro

(2019) Falko Lange et al.   PLoS One

Signaling in the microenvironment of pancreatic cancer: Transmitting along the nerve

(2019) Noelle Jurcak et al.   PHARMACOLOGY & THERAPEUTICS

Tumor Neurobiology and the War of Nerves in Cancer

(2019) Sam Faulkner et al.   Cancer Discovery

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

(2019) Noelle R. Jurcak et al.   GASTROENTEROLOGY

Clonal replacement of tumor-specific T cells following PD-1 blockade

(2019) Kathryn E. Yost et al.   NATURE MEDICINE

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

(2019) Marine Leclerc et al.   Nature Communications

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Synaptic proximity enables NMDAR signalling to promote brain metastasis

(2019) Qiqun Zeng et al.   NATURE

Blockade of β-Adrenergic Receptors Improves CD8+ T-cell Priming and Cancer Vaccine Efficacy

(2019) Clara Daher et al.   Cancer Immunology Research

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propranolol for Off-label Treatment of Patients With Melanoma

(2018) Vincenzo De Giorgi et al.   JAMA Oncology

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

(2018) Bernhard W Renz et al.   Cancer Discovery

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

(2017) Ali H. Zahalka et al.   SCIENCE

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

(2016) Sonam Dolma et al.   CANCER CELL

Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma

(2016) Caroline Happold et al.   JOURNAL OF CLINICAL ONCOLOGY

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

(2016) Jami L. Saloman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

(2016) C. Leah B. Kline et al.   Science Signaling

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

(2016) Caroline P. Le et al.   Nature Communications

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

(2016) C. Leah B. Kline et al.   Science Signaling

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

(2015) Ksenya Shchors et al.   CANCER CELL

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

(2015) Shelby C. Peterson et al.   Cell Stem Cell

Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma

(2015) Omar Babateen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma

(2015) Jie Li et al.   Oncotarget

GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy

(2014) Susan L. Campbell et al.   GLIA

Neurotrophin Signaling via TrkB and TrkC Receptors Promotes the Growth of Brain Tumor-initiating Cells

(2014) Samuel Lawn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors

(2014) Akiko Nakai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GFR 1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling

(2014) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

(2014) J. Neman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Nerve-cancer interactions in the stromal biology of pancreatic cancer

(2012) Ihsan Ekin Demir   Frontiers in Physiology

Brain-Derived Neurotrophic Factor Promotes Tumorigenesis via Induction of Neovascularization: Implication in Hepatocellular Carcinoma

(2011) C.-T. Lam et al.   CLINICAL CANCER RESEARCH

Beta-Blocker Use Is Associated With Improved Relapse-Free Survival in Patients With Triple-Negative Breast Cancer

(2011) Amal Melhem-Bertrandt et al.   JOURNAL OF CLINICAL ONCOLOGY

Selective Serotonin Reuptake Inhibitors, Glioblastoma Multiforme, and Impact on Toxicities and Overall Survival

(2010) Jonathan S. Caudill et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer

(2010) E. K. Sloan et al.   CANCER RESEARCH

Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis

(2010) S. M. Knox et al.   SCIENCE

Perineural invasion in cancer

(2009) Catherine Liebig et al.   CANCER

Tyrosine kinase B receptor and BDNF expression in ovarian cancers – Effect on cell migration, angiogenesis and clinical outcome

(2009) Christy W.H. Au et al.   CANCER LETTERS

Talampanel With Standard Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma: A Multicenter Phase II Trial

(2009) Stuart A. Grossman et al.   JOURNAL OF CLINICAL ONCOLOGY

Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas

(2009) Kaisorn L. Chaichana et al.   JOURNAL OF NEUROSURGERY

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance

(2009) E. A. Perez   MOLECULAR CANCER THERAPEUTICS

Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

(2008) E. Adriaenssens et al.   CANCER RESEARCH