Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila.

Apolipoproteins L1-6 share key cation channel-regulating residues but have different membrane insertion and ion conductance properties

(2021) Jyoti Pant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic Effects

(2021) Daria Müller et al.   MOLECULAR BIOLOGY AND EVOLUTION

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

(2020) Sophie Uzureau et al.   Cell Reports

Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

(2020) Joseph A Giovinazzo et al.   eLife

Cation channel conductance and pH gating of the innate immunity factor APOL1 is governed by pore lining residues within the C-terminal domain

(2020) Charles Schaub et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes

(2020) Suzie J. Scales et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

COVAN is the new HIVAN: the re-emergence of collapsing glomerulopathy with COVID-19

(2020) Juan Carlos Q. Velez et al.   Nature Reviews Nephrology

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity

(2019) Justin Chun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background

(2019) Herbert Lannon et al.   KIDNEY INTERNATIONAL

APOL1 and Kidney Disease: From Genetics to Biology

(2019) David J. Friedman et al.   Annual Review of Physiology

APOL1 Risk Variants Cause Podocytes Injury through Enhancing Endoplasmic Reticulum Stress

(2018) Hongxiu Wen et al.   BIOSCIENCE REPORTS

Genome-wide association studies suggest that APOL1 -environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1 –second gene interactions

(2018) Carl D. Langefeld et al.   KIDNEY INTERNATIONAL

ATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum

(2018) Maria Clara Guida et al.   MOLECULAR BIOLOGY OF THE CELL

UBDmodifiesAPOL1-induced kidney disease risk

(2018) Jia-Yue Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease

(2018) Pazit Beckerman et al.   TRENDS IN MOLECULAR MEDICINE

Dilemmas and challenges in apolipoprotein L1 nephropathy research

(2018) Etty Kruzel-Davila et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Apolipoprotein L1 confers pH-switchable ion permeability to phospholipid vesicles

(2017) Jonathan Bruno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion

(2017) Daniel Granado et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

(2017) Salim S Hayek et al.   NATURE MEDICINE

APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease

(2016) L. A. Bruggeman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort

(2016) J. Kozlitina et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

(2016) Lijun Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death

(2016) Yulong Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1–Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes

(2016) Etty Kruzel-Davila et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Modeling Monogenic Human Nephrotic Syndrome in theDrosophilaGarland Cell Nephrocyte

(2016) Tobias Hermle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1 and Kidney Disease in African Americans

(2016) David J. Friedman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin

(2016) Ahmed M. Kotb et al.   PLoS One

Drosophila as a model for unfolded protein response research

(2015) Hyung Don Ryoo   BMB Reports

Protein domains of APOL1 and its risk variants

(2015) Xiqian Lan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells

(2015) Dongmei Cheng et al.   JOURNAL OF LIPID RESEARCH

Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes

(2015) H. Hassan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis

(2015) Russell Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

(2015) Opeyemi A. Olabisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 Kidney Disease Risk Variants: An Evolving Landscape

(2015) Patrick D. Dummer et al.   SEMINARS IN NEPHROLOGY

ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death

(2014) Siqin Zhaorigetu et al.   Autophagy

Evolution of the primate trypanolytic factor APOL1

(2014) R. Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma Apolipoprotein L1 Levels Do Not Correlate with CKD

(2013) L. A. Bruggeman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cubilin and Amnionless Mediate Protein Reabsorption in Drosophila Nephrocytes

(2012) F. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Null Alleles from a Rural Village in India Do Not Correlate with Glomerulosclerosis

(2012) Duncan B. Johnstone et al.   PLoS One

The APOL1 Gene and Allograft Survival after Kidney Transplantation

(2011) A. M. Reeves-Daniel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

Apolipoprotein L1, a Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death

(2008) Guanghua Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

(2008) Helen Weavers et al.   NATURE