Apolipoproteins L1-6 share key cation channel-regulating residues but have different membrane insertion and ion conductance properties

A transcriptional blood signature distinguishes early tuberculosis disease from latent tuberculosis infection and uninfected individuals in a Vietnamese cohort

(2020) Jennifer Ho et al.   JOURNAL OF INFECTION

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

(2020) Sophie Uzureau et al.   Cell Reports

Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

(2020) Joseph A Giovinazzo et al.   eLife

Cation channel conductance and pH gating of the innate immunity factor APOL1 is governed by pore lining residues within the C-terminal domain

(2020) Charles Schaub et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function

(2020) Somenath Datta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes

(2020) Suzie J. Scales et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

(2020) Nidhi Gupta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

SignalP 5.0 improves signal peptide predictions using deep neural networks

(2019) José Juan Almagro Armenteros et al.   NATURE BIOTECHNOLOGY

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background

(2019) Herbert Lannon et al.   KIDNEY INTERNATIONAL

Autophagy during viral infection — a double-edged sword

(2018) Younho Choi et al.   NATURE REVIEWS MICROBIOLOGY

Monitoring voltage fluctuations of intracellular membranes

(2018) Masoud Sepehri Rad et al.   Scientific Reports

Viral journeys on the intracellular highways

(2018) Makeda Robinson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rattusin structure reveals a novel defensin scaffold formed by intermolecular disulfide exchanges

(2017) Hye Jung Min et al.   Scientific Reports

The C-terminal Domains of Apoptotic BH3-only Proteins Mediate Their Insertion into Distinct Biological Membranes

(2016) Vicente Andreu-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptomic Biomarkers for Tuberculosis: Evaluation of DOCK9. EPHA4, and NPC2 mRNA Expression in Peripheral Blood

(2016) Leonardo S. de Araujo et al.   Frontiers in Microbiology

Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1

(2015) Atanu K. Khatua et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates

(2015) Giuseppe Maulucci et al.   Autophagy

Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1

(2015) Brendan Nichols et al.   KIDNEY INTERNATIONAL

Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis

(2015) Russell Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

(2015) Opeyemi A. Olabisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of the primate trypanolytic factor APOL1

(2014) R. Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma membrane signaling in HIV-1 infection

(2013) Wasim Abbas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Innate Immune Factor Apolipoprotein L1 Restricts HIV-1 Infection

(2013) H. E. Taylor et al.   JOURNAL OF VIROLOGY

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Apolipoprotein L6, Induced in Atherosclerotic Lesions, Promotes Apoptosis and Blocks Beclin 1-dependent Autophagy in Atherosclerotic Cells

(2011) Siqin Zhaorigetu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Population-Based Risk Assessment of APOL1 on Renal Disease

(2011) D. J. Friedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

A Bacterial Protein Targets the BAHD1 Chromatin Complex to Stimulate Type III Interferon Response

(2011) A. Lebreton et al.   SCIENCE

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions

(2009) E. E. Smith et al.   GENOME RESEARCH

Trypanosome Lytic Factor, an Antimicrobial High-Density Lipoprotein, Ameliorates Leishmania Infection

(2009) Marie Samanovic et al.   PLoS Pathogens

HELIQUEST: a web server to screen sequences with specific  -helical properties

(2008) R. Gautier et al.   BIOINFORMATICS

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model

(2008) Maria Pilar Molina-Portela et al.   JOURNAL OF EXPERIMENTAL MEDICINE