Drosophila as a model for unfolded protein response research

Regulation of axon regeneration by the RNA repair and splicing pathway

(2015) Yuanquan Song et al.   NATURE NEUROSCIENCE

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

(2015) Lifen Wang et al.   PLoS Genetics

Induction of Excessive Endoplasmic Reticulum Stress in the Drosophila Male Accessory Gland Results in Infertility

(2015) Clement Y. Chow et al.   PLoS One

A Drosophila Reporter for the Translational Activation of ATF4 Marks Stressed Cells during Development

(2015) Kwonyoon Kang et al.   PLoS One

Redox regulation in the endoplasmic reticulum

(2014) Neil J. Bulleid et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The mammalian tRNA ligase complex mediates splicing ofXBP1mRNA and controls antibody secretion in plasma cells

(2014) Jennifer Jurkin et al.   EMBO JOURNAL

The RtcB RNA ligase is an essential component of the metazoan unfolded protein response

(2014) S. G. Kosmaczewski et al.   EMBO REPORTS

Reduction of endoplasmic reticulum stress attenuates the defects caused byDrosophilamitofusin depletion

(2014) Valentina Debattisti et al.   JOURNAL OF CELL BIOLOGY

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα

(2014) Thomas D. Baird et al.   MOLECULAR BIOLOGY OF THE CELL

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB

(2014) Yanyan Lu et al.   MOLECULAR CELL

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development

(2014) Jiongming Lu et al.   Nature Communications

Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell Proliferation

(2014) Lifen Wang et al.   PLoS Genetics

Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup

(2013) C. Groth et al.   DEVELOPMENT

Genetic Complexity in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin

(2013) S.-Y. Park et al.   GENETICS

The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control

(2013) Amina Moustaqim-Barrette et al.   HUMAN MOLECULAR GENETICS

Coordinate regulation of eIF2  phosphorylation by PPP1R15 and GCN2 is required during Drosophila development

(2013) E. Malzer et al.   JOURNAL OF CELL SCIENCE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye

(2013) Takahiro Suzuki et al.   PLoS One

Drosophila XBP1 Expression Reporter Marks Cells under Endoplasmic Reticulum Stress and with High Protein Secretory Load

(2013) Hyung Don Ryoo et al.   PLoS One

Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes

(2013) C. Y. Chow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development

(2012) Michio Sone et al.   CELL STRESS & CHAPERONES

Reticulon-like-1, the Drosophila orthologue of the Hereditary Spastic Paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons

(2012) N. C. O'Sullivan et al.   HUMAN MOLECULAR GENETICS

Comparison of mRNA localization and regulation during endoplasmic reticulum stress in Drosophila cells

(2012) Deepika Gaddam et al.   MOLECULAR BIOLOGY OF THE CELL

CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model

(2012) Min-Ji Kang et al.   NATURE CELL BIOLOGY

Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2

(2012) Sebastien A. Gauthier et al.   PLoS Genetics

Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila

(2011) T. Yamakawa et al.   DEVELOPMENT

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

(2010) E. Malzer et al.   JOURNAL OF CELL SCIENCE

The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo

(2010) Carin A. Loewen et al.   PLoS One

Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila

(2010) Ana Griciuc et al.   PLoS Genetics

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

ER stress protects from retinal degeneration

(2009) César S Mendes et al.   EMBO JOURNAL

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

A Genetic Screen in Drosophila Reveals Novel Cytoprotective Functions of the Autophagy-Lysosome Pathway

(2009) Andrew M. Arsham et al.   PLoS One

Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation

(2009) M.-J. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

(2008) Melih Acar et al.   CELL

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

(2008) Hiroshi Tsuda et al.   CELL

Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats inDrosophila melanogaster

(2008) An-Chi Tien et al.   JOURNAL OF CELL BIOLOGY

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE