Functional exhaustion of CD4+T cells induced by co-stimulatory signals from myeloid leukaemia cells

TIM-3/Gal-9 interaction induces IFNγ-dependent IDO1 expression in acute myeloid leukemia blast cells

(2015) Valentina Folgiero et al.   Journal of Hematology & Oncology

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

(2015) Y Kong et al.   Blood Cancer Journal

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

(2015) A. Ribas   Cancer Discovery

Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders

(2014) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

Adaptive resistance: A tumor strategy to evade immune attack

(2013) Sheng Yao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-specific CD4+T cells maintain effector and memory tumor-specific CD8+T cells

(2013) Sarah E. Church et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Restoring Immune Function of Tumor-Specific CD4+ T Cells during Recurrence of Melanoma

(2013) S. R. Goding et al.   JOURNAL OF IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells

(2013) Amandine Legat et al.   Frontiers in Immunology

TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

(2013) Kaori Sakuishi et al.   OncoImmunology

T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production

(2012) J. C. Riches et al.   BLOOD

Myeloid leukemia cells with a B7-2+subpopulation provoke Th-cell responses and become immuno-suppressive through the modulation of B7 ligands

(2012) Yusuf Dolen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional Exhaustion of CD4+ T Lymphocytes during Primary Cytomegalovirus Infection

(2012) P. Antoine et al.   JOURNAL OF IMMUNOLOGY

The Role of Antigen Cross-presentation From Leukemia Blasts on Immunity to the Leukemia-associated Antigen PR1

(2012) Gheath Alatrash et al.   JOURNAL OF IMMUNOTHERAPY

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

PD-1/PD-L1 Interactions Contribute to Functional T-Cell Impairment in Patients Who Relapse with Cancer After Allogeneic Stem Cell Transplantation

(2011) W. J. Norde et al.   CANCER RESEARCH

Reduced tumor-antigen density leads to PD-1/PD-L1-mediated impairment of partially exhausted CD8+ T cells

(2011) Andrew D. Kaiser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-bet, a Th1 transcription factor regulates the expression of Tim-3

(2010) Ana C. Anderson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression

(2009) S. Mumprecht et al.   BLOOD