Tyrosine kinase signaling pathways in neutrophils

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation

(2016) Stephanie Volmering et al.   IMMUNITY

Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2

(2016) Jackson LiangYao Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Feedback Amplification of Neutrophil Function

(2016) Tamás Németh et al.   TRENDS IN IMMUNOLOGY

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

(2016) Tamás Németh et al.   Nature Communications

Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis

(2016) Lindsay E. Nyhoff et al.   Arthritis & Rheumatology

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

Intracellular signalling during neutrophil recruitment

(2015) Attila Mócsai et al.   CARDIOVASCULAR RESEARCH

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

The era of the immunoglobulin A Fc receptor FcαRI; its function and potential as target in disease

(2015) Esil Aleyd et al.   IMMUNOLOGICAL REVIEWS

Discovering the first tyrosine kinase

(2015) Tony Hunter   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SRC: A Century of Science Brought to the Clinic

(2015) Alexey Aleshin et al.   NEOPLASIA

Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects

(2014) R. P. Gazendam et al.   BLOOD

Social networking of human neutrophils within the immune system

(2014) P. Scapini et al.   BLOOD

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

The Effects of Bruton Tyrosine Kinase Inhibition on Chemotaxis and Superoxide Generation in Human Neutrophils

(2014) Arnon Broides et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

(2014) Miklós Kovács et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

(2014) Felix C. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1

(2014) Martina Behnen et al.   JOURNAL OF IMMUNOLOGY

Neutrophil-Derived Cytokines: Facts Beyond Expression

(2014) Cristina Tecchio et al.   Frontiers in Immunology

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling

(2013) J. M. Herter et al.   BLOOD

The high-affinity human IgG receptor Fc RI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy

(2013) D. A. Mancardi et al.   BLOOD

Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response

(2013) S. M. Jakob et al.   BLOOD

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency

(2013) A. Drewniak et al.   BLOOD

Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

(2013) Attila Mócsai   JOURNAL OF EXPERIMENTAL MEDICINE

B Cell-Specific Loss of Lyn Kinase Leads to Autoimmunity

(2013) C. Lamagna et al.   JOURNAL OF IMMUNOLOGY

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation

(2013) Susanne Roth et al.   TRENDS IN IMMUNOLOGY

Leukocyte adhesion deficiencies

(2012) Suhair Hanna et al.   Annals of the New York Academy of Sciences

Endocytosis of soluble immune complexes leads to their clearance by Fc RIIIB but induces neutrophil extracellular traps via Fc RIIA in vivo

(2012) K. Chen et al.   BLOOD

Dasatinib inhibits proinflammatory functions of mature human neutrophils

(2012) K. Futosi et al.   BLOOD

Properties of mouse and human IgG receptors and their contribution to disease models

(2012) P. Bruhns   BLOOD

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis

(2012) N. Ozaki et al.   INTERNATIONAL IMMUNOLOGY

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury

(2012) Helena Block et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

(2012) Fumiko Honda et al.   NATURE IMMUNOLOGY

The β-Glucan Receptor Dectin-1 Activates the Integrin Mac-1 in Neutrophils via Vav Protein Signaling to Promote Candida albicans Clearance

(2011) Xun Li et al.   Cell Host & Microbe

Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption

(2011) Zsuzsanna Kertész et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo

(2011) Eva Wex et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity

(2011) Thorsten B. Feyerabend et al.   IMMUNITY

Cutting Edge: The Murine High-Affinity IgG Receptor Fc RIV Is Sufficient for Autoantibody-Induced Arthritis

(2011) D. A. Mancardi et al.   JOURNAL OF IMMUNOLOGY

Deletion of Syk in Neutrophils Prevents Immune Complex Arthritis

(2011) Emily R. Elliott et al.   JOURNAL OF IMMUNOLOGY

Class IA Phosphoinositide 3-Kinase   and   Regulate Neutrophil Oxidase Activation in Response to Aspergillus fumigatus Hyphae

(2011) K. B. Boyle et al.   JOURNAL OF IMMUNOLOGY

PI3K  Plays a Critical Role in Neutrophil Activation by Immune Complexes

(2011) S. Kulkarni et al.   Science Signaling

Neutrophils in a mouse model of autoantibody-mediated arthritis: Critical producers of Fc receptor γ, the receptor for C5a, and lymphocyte function−associated antigen 1

(2010) Paul A. Monach et al.   ARTHRITIS AND RHEUMATISM

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia

(2010) K. Fiedler et al.   BLOOD

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC)  2 and PI3K  pathways

(2010) H. Mueller et al.   BLOOD

Neutrophil Functions and Autoimmune Arthritis in the Absence of p190RhoGAP: Generation and Analysis of a Novel Null Mutation in Mice

(2010) T. Nemeth et al.   JOURNAL OF IMMUNOLOGY

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Src-family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross Talk

(2010) C. A. Lowell   Cold Spring Harbor Perspectives in Biology

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

A fundamental role of mAbp1 in neutrophils: impact on  2 integrin-mediated phagocytosis and adhesion in vivo

(2009) J. Schymeinsky et al.   BLOOD

The tyrosine kinase network regulating mast cell activation

(2009) Alasdair M. Gilfillan et al.   IMMUNOLOGICAL REVIEWS

Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis

(2009) Laurie E. Lenox et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation

(2009) Kerstin Werninghaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Vav/Phospholipase Cγ2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis

(2008) Viviana Cremasco et al.   ARTHRITIS AND RHEUMATISM

Identification of Fc RIIa as the ITAM-bearing receptor mediating  IIb 3 outside-in integrin signaling in human platelets

(2008) B. Boylan et al.   BLOOD

The diverse functions of Src family kinases in macrophages

(2008) Clare et al.   Frontiers in Bioscience-Landmark

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

(2008) S. Wakselman et al.   JOURNAL OF NEUROSCIENCE

Phospholipase C 2 Modulates Integrin Signaling in the Osteoclast by Affecting the Localization and Activation of Src Kinase

(2008) H. Epple et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE