Review
Immunology
Ya-Ru Shao, Dan-Yi Xu, Jin Lin
Summary: Neutrophils are core immune cells involved in the early stage of rheumatoid arthritis and play a role in disease progression. Mechanisms include increased neutrophil chemotaxis and infiltration, elevated reactive oxygen species, and enhanced formation of neutrophil extracellular traps. Various nutrients have been found to regulate rheumatoid arthritis by modulating activated neutrophils, emphasizing the importance of a healthy diet for individuals at risk of or suffering from rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Moanna Villaluz, Lynette Dunning, Carl S. Goodyear, William R. Ferrell, John C. Lockhart, Andrew MacKenzie
Summary: The study showed that losartan has a significant mitigating effect on joint swelling, pain sensation, and vascular dysfunction in inflammatory arthritis, indicating that the angiotensin II-type 1 receptor could be an important therapeutic target for the development of physical changes in arthritis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Min Liu, Siyi Liu, Lin Liu, Jingya Xiu, Tian Zhang, Dawei Chen, Mingxi Qiao, Haiyang Hu, Jiulong Zhang, Xiuli Zhao
Summary: Rheumatoid arthritis (RA) is characterized by inflammation outbreak and joint destruction. Neutrophils play a crucial role in RA by releasing excess neutrophil extracellular traps (NETs), but preventing NETs formation is still challenging. In this study, a method using sivelestat-conjugated bovine serum albumin nanoparticles (BTST NPs) was established to selectively inhibit neutrophil elastase (NE) and prevent NETs production. Additionally, the BTST NPs were loaded with dexamethasone palmitate (DP) for synergistic treatment of RA. The results showed that DP/BTST NPs could effectively target inflamed neutrophils, hinder NETs generation, and improve RA symptoms.
Article
Immunology
Xuanqi Liu, Yinping Huo, Jingyang Zhao, Guan Wang, Huiyang Liu, Fangrui Yin, Chunyan Pang, Yongfu Wang, Li Bai
Summary: The endothelial cell protein C receptor (EPCR) plays a crucial role in rheumatoid arthritis (RA) by affecting the disease progression and function of polymorphonuclear neutrophils (PMN). PMN cells with low EPCR expression migrate into the joint cavity and contribute to RA synovial inflammation, leading to bone destruction. The formation of PMN-neutrophil extracellular traps (NETs) in RA patients is increased, which can be regulated by the APC-EPCR signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Ni Yang, Miaomiao Li, Ling Wu, Yinhong Song, Shi Yu, Yingying Wan, Wenjing Cheng, Baoye Yang, Xiaoqin Mou, Hong Yu, Jing Zheng, Xinzhi Li, Xiang Yu
Summary: The development of a biomimetic ApoA-I mimetic peptide-modified neutrophil membrane-wrapped F127 polymer (R4F-NM@F127) provides a potential therapeutic strategy for rheumatoid arthritis (RA) by targeting macrophage polarization in the synovium and synovial fluid.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Immunology
Xiangsu Liu, Jiaqi Li, Leilei Sun, Tong Wang, Wenxia Liang
Summary: The inflammatory response plays a crucial role in joint injury in rheumatoid arthritis (RA), but it is difficult to assess inflammation levels, making diagnosis challenging. The neutrophil-to-lymphocyte ratio (NLR), a novel non-specific inflammatory indicator, reflects the severity of inflammation. This study aimed to explore the role of NLR in RA progression and evaluate its predictive value for response to disease-modifying antirheumatic drugs (DMARDs) therapy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Erye Zhou, Jian Wu, Xin Zhou, Yufeng Yin
Summary: This study investigated the association between neutrophil-to-lymphocyte ratio (NLR) and all-cause and cardiovascular mortality risk in individuals with rheumatoid arthritis (RA). The study found that individuals with higher NLR had a 2-fold increased risk of long-term mortality. NLR may serve as an inexpensive and widely available prognostic marker in RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Merel A. A. Opdam, J. H. de Leijer, Nathan den Broeder, Rogier M. Thurlings, Wilfred van der Weele, Michael T. Nurmohamed, Marc R. Kok, Lenny van Bon, David F. Ten Cate, Lise M. Verhoef, Alfons A. den Broeder
Summary: In this post hoc analysis of the REDO trial, it was found that potential mediators such as circulating B-cell counts, immunoglobulin levels, neutrophil counts, and drug use did not explain the observed dose-dependent infection risk. Additionally, a trend towards higher infection rates shortly after RTX infusion was identified.
Article
Pharmacology & Pharmacy
Ayda Henriques Schneider, Thaise Mayumi Taira, Gabriel Azevedo Publio, Douglas da Silva Prado, Paula Barbim Donate Yabuta, Jessica Cristina dos Santos, Caio Cavalcante Machado, Flavio Falcao Lima de Souza, Lucas Gabriel Rodrigues Venturini, Rene Donizeti Ribeiro de Oliveira, Thiago Mattar Cunha, Jose Carlos Alves-Filho, Paulo Louzada-Junior, Tarcilia Aparecida da Silva, Sandra Yasuyo Fukada, Fernando Queiroz Cunha
Summary: The study found that patients with rheumatoid arthritis had higher levels of NETs in synovial fluid, and inhibiting NETs could be a potential strategy to reduce bone erosion in arthritis patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiaxin Li, Yang Long, Rong Guo, Kebai Ren, Zhengze Lu, Man Li, Xuhui Wang, Jiaxin Li, Yashi Wang, Zhirong Zhang, Qin He
Summary: A novel anti-inflammatory strategy based on neutrophils has been developed, showing significant therapeutic efficacy for rheumatoid arthritis by using LMWH-TOS nanoparticles.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Merel A. A. Opdam, Sophie Benoy, Lise M. Verhoef, Sandra Van Bijnen, Femke Lamers-Karnebeek, Rene A. M. Traksel, Petra Vos, Alfons A. den Broeder, Jasper Broen
Summary: Patients with inflammatory rheumatic diseases do not have an increased risk for COVID-19 compared to the general population. Older age and obesity are major risk factors for hospitalization for COVID-19 in patients with IRD, while the use of methotrexate may have a protective effect in reducing the risk of hospitalization.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Immunology
Cen Chang, Lingxia Xu, Runrun Zhang, Yehua Jin, Ping Jiang, Kai Wei, Linshuai Xu, Yiming Shi, Jianan Zhao, Momiao Xiong, Shicheng Guo, Dongyi He
Summary: MicroRNAs (miRNAs) play crucial roles in the pathogenesis, diagnosis, and therapeutic intervention of rheumatoid arthritis (RA). They regulate gene expression, immune system differentiation, and serve as potential biomarkers and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Shan-shan Jie, Hui-juan Sun, Jian-xin Liu, Yan Gao, Dong Bai, Liu-luan Zhu, Hong-yan Zhao, Hui Zeng, Ya-luan Ma
Summary: Traditional Chinese prescription SMYAD has remarkable anti-inflammatory properties and effectively relieves arthritis in rheumatoid arthritis (RA) mice by modulating neutrophil activities.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Ghada A. Otaify, Michael P. Whyte, Gary S. Gottesman, William H. McAlister, J. Eric Gordon, Abby Hollander, Marisa V. Andrews, Samir K. El-Mofty, Wei-Shen Chen, Deborah V. Veis, Marina Stolina, Albert S. Woo, Panagiotis Katsonis, Olivier Lichtarge, Fan Zhang, Marwan Shinawi
Article
Oncology
Wendy Yen Yun Chou, Deborah J. Veis, Rebecca Aft
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Endocrinology & Metabolism
Michael P. Whyte, Emilina Lim, William H. McAlister, Gary S. Gottesman, Lien Trinh, Deborah J. Veis, Vinieth N. Bijanki, Matthew G. Boden, Angela Nenninger, Steven Mumm, David Buchbinder
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Endocrinology & Metabolism
Yan Zhang, Nidhi Rohatgi, Deborah J. Veis, Joel Schilling, Steven L. Teitelbaum, Wei Zou
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Endocrinology & Metabolism
Morten Frost, Michaela Tencerova, Christina M. Andreasen, Thomas L. Andersen, Charlotte Ejersted, Dea Svaneby, Weimin Qui, Moustapha Kassem, Allandad Zarei, William H. McAlister, Deborah J. Veis, Michael P. Whyte, Anja L. Frederiksen
Article
Immunology
Sahil Mahajan, Corinne E. Decker, Zhengfeng Yang, Deborah Veis, Elizabeth D. Mellins, Roberta Faccio
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Microbiology
Alissa R. Young, Marissa C. Locke, Lindsey E. Cook, Bradley E. Hiller, Rong Zhang, Matthew L. Hedberg, Kristen J. Monte, Deborah J. Veis, Michael S. Diamond, Deborah J. Lenschow
Article
Microbiology
Jennifer L. Krauss, Philip M. Roper, Anna Ballard, Chien-Cheng Shih, James A. J. Fitzpatrick, James E. Cassat, Pei Ying Ng, Nathan J. Pavlos, Deborah J. Veis
Article
Endocrinology & Metabolism
Anna Cline-Smith, Ariel Axelbaum, Elena Shashkova, Mousumi Chakraborty, Jessie Sanford, Prabhjyot Panesar, Macey Peterson, Linda Cox, Angel Baldan, Deborah Veis, Rajeev Aurora
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L. Kostecki, Joseph B. Monahan, Deborah J. Veis, Yousef Abu-Amer, Daniel C. Link, Gabriel Mbalaviele
Review
Cell Biology
Philip M. Roper, Christine Shao, Deborah J. Veis
Article
Endocrinology & Metabolism
Deborah J. Veis, James E. Cassat
Summary: Bone infections can be caused by a variety of bacteria, with Staphylococcus aureus being the most common culprit. There remain many unanswered questions about the mechanisms and treatment of these infections, suggesting that interdisciplinary approaches may bring new insights to the field.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Bradley T. Estes, Masataka Enomoto, Franklin T. Moutos, Megan A. Carson, Jeffrey M. Toth, Peter Eggert, Jonathan Stallrich, Vincent P. Willard, Deborah J. Veis, Dianne Little, Farshid Guilak, B. Duncan X. Lascelles
Summary: The study demonstrated that a tissue-engineered bicomponent implant, combining new technologies and components, was able to restore hip function in a canine model of hip osteoarthritis. The implant showed potential as a therapy for moderate hip osteoarthritis, providing clinically relevant evidence of its efficacy.
Proceedings Paper
Microscopy
Terence T. W. Wong, Ruiying Zhang, Pengfei Hai, Rebecca L. Aft, Deborah V. Novack, Lihong V. Wang
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2018
(2018)
Article
Medicine, Research & Experimental
Ashraf Ul Kabir, Tae-Jin Lee, Hua Pan, Jeffrey C. Berry, Karen Krchma, Jun Wu, Fang Liu, Hee-Kyoung Kang, Kristina Hinman, Lihua Yang, Samantha Hamilton, Qingyu Zhou, Deborah J. Veis, Robert P. Mecham, Samuel A. Wickline, Mark J. Miller, Kyunghee Choi