A Derivative of Piperlongumine and Ligustrazine as a Potential Thioredoxin Reductase Inhibitor in Drug-Resistant Hepatocellular Carcinoma

Overview of Piperlongumine Analogues and their Therapeutic Potential

(2021) Peng Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation

(2021) Ai-Ling Sun et al.   MOLECULES

Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy

(2020) Yong Ling et al.   CURRENT MEDICINAL CHEMISTRY

CD147 promotes DNA damage response and gemcitabine resistance via targeting ATM/ATR/p53 and affects prognosis in pancreatic cancer

(2020) Yinghui Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential

(2020) Mirna Jovanović et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Azo-inserted responsive hybrid liposomes for hypoxia-specific drug delivery

(2020) Mengmeng Long et al.   Acta Biomaterialia

Novel Phenylmethylenecyclohexenone Derivatives as Potent TrxR Inhibitors Display High Antiproliferative Activity and Induce ROS, Apoptosis, and DNA Damage

(2020) Xiaomei Wang et al.   ChemMedChem

Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy

(2020) Jianqiang Qian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling

(2020) Peng Zhu et al.   JOURNAL OF NATURAL PRODUCTS

Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress

(2019) Tianyu Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Piperlongumine induces autophagy in biliary cancer cells via�reactive oxygen species-activated Erk signaling pathway

(2019) San‑Yuan Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Piperlongumine Inhibits Akt Phosphorylation to Reverse Resistance to Cisplatin in Human Non-Small Cell Lung Cancer Cells via ROS Regulation

(2019) Chao Zhang et al.   Frontiers in Pharmacology

Design, synthesis and bioactivity evaluation of coumarin-chalcone hybrids as potential anticancer agents

(2019) Yu Wang et al.   BIOORGANIC CHEMISTRY

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives

(2018) Jinmi Zou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Monoubiquitinated γ-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks

(2018) Michal W. Luczak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway

(2018) Yan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells

(2016) Mei-ling Han et al.   ACTA PHARMACOLOGICA SINICA

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

(2016) Peng Zou et al.   CANCER LETTERS

ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure

(2016) Jianbin Ge et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells

(2016) Yapeng Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway

(2016) Jie Zheng et al.   Scientific Reports

Piperlongumine Suppresses Growth and Sensitizes Pancreatic Tumors to Gemcitabine in a Xenograft Mouse Model by Modulating the NF-kappa B Pathway

(2015) Y. Wang et al.   Cancer Prevention Research

Tetramethylpyrazine (TMP) exerts antitumor effects by inducing apoptosis and autophagy in hepatocellular carcinoma

(2015) Jiao Cao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Piperlongumine reverses doxorubicin resistance through the PI3K/Akt signaling pathway in K562/A02 human leukemia cells

(2015) QINGWEI KANG et al.   Experimental and Therapeutic Medicine

Baicalin Induces Apoptosis of Gallbladder Carcinoma Cells in vitro via a Mitochondrial-Mediated Pathway and Suppresses Tumor Growth in vivo

(2014) Yi-Jun Shu et al.   Anti-Cancer Agents in Medicinal Chemistry

Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells

(2014) Nan Xie et al.   BIOCHEMICAL PHARMACOLOGY

Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

(2014) P Makhov et al.   BRITISH JOURNAL OF CANCER

Piperlongumine induces inhibition of the ubiquitin–proteasome system in cancer cells

(2013) Malin Jarvius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tetramethylpyrazine inhibits osteosarcoma cell proliferation via downregulation of NF-κB in vitro and in vivo

(2013) YONG WANG et al.   Molecular Medicine Reports

Piperlongumine induces autophagy by targeting p38 signaling

(2013) Y Wang et al.   Cell Death & Disease

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

(2012) D. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetramethylpyrazine reverses multidrug resistance in breast cancer cells through regulating the expression and function of P-glycoprotein

(2011) Yinxu Zhang et al.   MEDICAL ONCOLOGY

Biomimetic Oxidation of Piperine and Piplartine Catalyzed by Iron(III) and Manganese(III) Porphyrins

(2010) Estela Hanauer Schaab et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY