Ring A/B-Modified 17β-Hydroxywithanolide Analogues as Antiproliferative Agents for Prostate Cancer and Potentiators of Immunotherapy for Renal Carcinoma and Melanoma

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

(2021) Poonam Tewary et al.   CANCER RESEARCH

Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation

(2018) E. M. Kithsiri Wijeratne et al.   JOURNAL OF NATURAL PRODUCTS

Androgen-targeted therapy in men with prostate cancer: evolving practice and future considerations

(2018) E. David Crawford et al.   PROSTATE CANCER AND PROSTATIC DISEASES

17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure–Activity Relationships

(2017) Ya-Ming Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells

(2017) Ya-Ming Xu et al.   JOURNAL OF NATURAL PRODUCTS

Coagulansin-A has beneficial effects on the development of bovine embryos in vitro via HSP70 induction

(2016) I. Khan et al.   BIOSCIENCE REPORTS

Using natural products to promote caspase-8-dependent cancer cell death

(2016) Poonam Tewary et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Chemical Constituents and Biological Activities of Plants from the GenusPhysalis

(2016) Wen-Na Zhang et al.   CHEMISTRY & BIODIVERSITY

17β-Hydroxy-18-acetoxywithanolides from Aeroponically Grown Physalis crassifolia and Their Potent and Selective Cytotoxicity for Prostate Cancer Cells

(2016) Ya-ming Xu et al.   JOURNAL OF NATURAL PRODUCTS

Toll-like receptor 3 stimulation triggers metabolic reprogramming in pharyngeal cancer cell line through Myc, MAPK, and HIF

(2016) Tanja Matijevic Glavan et al.   MOLECULAR CARCINOGENESIS

Discovery of Potent 17β-Hydroxywithanolides for Castration-Resistant Prostate Cancer by High-Throughput Screening of a Natural Products Library for Androgen-Induced Gene Expression Inhibitors

(2015) Ya-Ming Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation

(2015) C J Henrich et al.   Cell Death & Disease

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

Enzalutamide: A Review of Its Use in Metastatic, Castration-Resistant Prostate Cancer

(2013) Mark Sanford   DRUGS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting the extrinsic apoptosis signaling pathway for cancer therapy

(2011) Thomas J. Sayers   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Natural withanolides: an overview

(2011) Li-Xia Chen et al.   NATURAL PRODUCT REPORTS

Castration-refractory prostate cancer: New drugs in the pipeline

(2010) Dirk Schrijvers et al.   ADVANCES IN THERAPY

Review: Castration-resistant prostate cancer: new science and therapeutic prospects

(2010) Joaquim Bellmunt et al.   Therapeutic Advances in Medical Oncology

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

(2009) A Weber et al.   CELL DEATH AND DIFFERENTIATION

A cell-based high-throughput screen to identify synergistic TRAIL sensitizers

(2008) Nancy Lynn Booth et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancers take their Toll—the function and regulation of Toll-like receptors in cancer cells

(2008) R Chen et al.   ONCOGENE