Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

Structure–Activity Relationships for Withanolides as Inducers of the Cellular Heat-Shock Response

(2014) E. M. Kithsiri Wijeratne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Death receptors as targets in cancer

(2013) O Micheau et al.   BRITISH JOURNAL OF PHARMACOLOGY

The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

(2013) N. Miyajima et al.   CANCER RESEARCH

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

(2013) K Azijli et al.   CELL DEATH AND DIFFERENTIATION

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

(2013) Nadine Wittkopf et al.   GASTROENTEROLOGY

Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells

(2013) Mancang Gu et al.   INVESTIGATIONAL NEW DRUGS

Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin

(2013) Marie L. Antony et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria: gatekeepers of response to chemotherapy

(2013) Kristopher A. Sarosiek et al.   TRENDS IN CELL BIOLOGY

Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone

(2013) V Khedgikar et al.   Cell Death & Disease

cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis

(2013) Diana Panayotova-Dimitrova et al.   Cell Reports

Targeting the Apo2L/TRAIL system for the therapy of autoimmune diseases and cancer

(2012) Luis Martinez-Lostao et al.   BIOCHEMICAL PHARMACOLOGY

Molecular insight in the multifunctional activities of Withaferin A

(2012) Wim Vanden Berghe et al.   BIOCHEMICAL PHARMACOLOGY

Bortezomib and TRAIL: A perfect match for apoptotic elimination of tumour cells?

(2012) L.H.A.M. de Wilt et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells

(2012) Gabriel G. LLanos et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions

(2012) Selcen Öztürk et al.   EXPERIMENTAL CELL RESEARCH

Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis

(2012) Markus David Siegelin   EXPERT OPINION ON THERAPEUTIC TARGETS

Synergistic TRAIL Sensitizers from Barleria alluaudii and Diospyros maritima

(2012) Emily L. Whitson et al.   JOURNAL OF NATURAL PRODUCTS

TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies

(2012) C. T. Hellwig et al.   MOLECULAR CANCER THERAPEUTICS

Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP

(2012) A Bangert et al.   ONCOGENE

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

(2012) L Y Dimberg et al.   ONCOGENE

Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90

(2012) Hui-Chun Wang et al.   PLoS One

Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

(2012) Saad Khan et al.   PLoS One

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

(2012) X. Piao et al.   Science Signaling

ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2

(2011) Rosa Martín-Pérez et al.   APOPTOSIS

Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2

(2011) Eleonore Mayola et al.   APOPTOSIS

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells

(2011) Nicholas S. Wilson et al.   CANCER CELL

Targeting the extrinsic apoptosis signaling pathway for cancer therapy

(2011) Thomas J. Sayers   CANCER IMMUNOLOGY IMMUNOTHERAPY

Distinct TRAIL Resistance Mechanisms Can Be Overcome by Proteasome Inhibition but not Generally by Synergizing Agents

(2011) C. Menke et al.   CANCER RESEARCH

Expression of c-FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease

(2011) F. Tian et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo

(2011) Jörn M. Schattenberg et al.   JOURNAL OF HEPATOLOGY

Natural withanolides: an overview

(2011) Li-Xia Chen et al.   NATURAL PRODUCT REPORTS

Clerodane Diterpenes fromCasearia argutaThat Act As Synergistic TRAIL Sensitizers

(2010) Emily L. Whitson et al.   JOURNAL OF NATURAL PRODUCTS

Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

(2010) Alan D. Brooks et al.   MOLECULAR CANCER RESEARCH

Withaferin A targets heat shock protein 90 in pancreatic cancer cells

(2009) Yanke Yu et al.   BIOCHEMICAL PHARMACOLOGY

Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2009) Tae-Jin Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

(2009) Mohammad Mirjalili et al.   MOLECULES

A cell-based high-throughput screen to identify synergistic TRAIL sensitizers

(2008) Nancy Lynn Booth et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

(2008) C Adams et al.   CELL DEATH AND DIFFERENTIATION