Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model

P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice

(2021) Li Jiang et al.   Journal of Neuroinflammation

Migraine: epidemiology and systems of care

(2021) Messoud Ashina et al.   LANCET

Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model

(2021) Yunfeng Wang et al.   JOURNAL OF HEADACHE AND PAIN

Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model

(2020) Ting Long et al.   JOURNAL OF HEADACHE AND PAIN

Sphingosine 1-phosphate receptor modulation attenuate mechanical allodynia in mouse model of chronic complex regional pain syndrome by suppressing pathogenic astrocyte activation

(2020) Byung Joo Lee et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

From transformation to chronification of migraine: pathophysiological and clinical aspects

(2020) M. Torres-Ferrús et al.   JOURNAL OF HEADACHE AND PAIN

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

(2020) Timothy M. Doyle et al.   PAIN

CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia

(2020) Zhongsheng Hu et al.   Cell Reports

Fingolimod suppressed the chronic unpredictable mild stress-induced depressive-like behaviors via affecting microglial and NLRP3 inflammasome activation

(2020) Yuanxin Guo et al.   LIFE SCIENCES

Sphingosine-1-phosphate induces migration of microglial cells via activation of volume-sensitive anion channels, ATP secretion and activation of purinergic receptors

(2020) Danyal Zahiri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway

(2019) Timothy M. Doyle et al.   JOURNAL OF PAIN

Behavioral and cognitive animal models in headache research

(2019) Doga Vuralli et al.   JOURNAL OF HEADACHE AND PAIN

Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

(2019) Wei He et al.   Journal of Neuroinflammation

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

(2019) Zhoumou Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation

(2019) Indulekha Karunakaran et al.   GLIA

Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation

(2019) Hsing-Chuan Tsai et al.   JOURNAL OF AUTOIMMUNITY

Animal models of migraine and experimental techniques used to examine trigeminal sensory processing

(2019) Andrea M. Harriott et al.   JOURNAL OF HEADACHE AND PAIN

A causal role for TRESK loss of function in migraine mechanisms

(2019) Philippa Pettingill et al.   BRAIN

P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine

(2019) Feng Jing et al.   Journal of Neuroinflammation

Up‐regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine

(2019) Xue Zhou et al.   JOURNAL OF NEUROCHEMISTRY

The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus

(2018) Fei Gao et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition

(2018)   CEPHALALGIA

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

(2018) Katherine Stockstill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sphingosine 1-Phosphate Receptor Subtype 1 as a Therapeutic Target for Brain Trauma

(2018) Salvatore Cuzzocrea et al.   JOURNAL OF NEUROTRAUMA

Chronic migraine: A process of dysmodulation and sensitization

(2018) Min Su et al.   Molecular Pain

Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn

(2018) Suzanne Doolen et al.   PAIN

Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation

(2018) Ting Long et al.   Journal of Neuroinflammation

Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide

(2018) Liansheng Zhong et al.   GLIA

S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway

(2018) Zhi Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

(2018) Gang Chen et al.   NEURON

Neuroprotective effects of fingolimod in mouse models of Parkinson’s disease

(2017) Peng Zhao et al.   FASEB JOURNAL

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

(2017) Nigel Pyne et al.   MOLECULES

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

(2017) Shaness A. Grenald et al.   PAIN

FTY720 attenuates excitotoxicity and neuroinflammation

(2015) Raffaela Cipriani et al.   Journal of Neuroinflammation

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

(2014) Kali Janes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pearls and pitfalls in experimental in vivo models of headache: Conscious behavioral research

(2013) Marcela Romero-Reyes et al.   CEPHALALGIA

Fingolimod phosphate promotes the neuroprotective effects of microglia

(2013) Hiromi Noda et al.   JOURNAL OF NEUROIMMUNOLOGY

Characterization of a novel model of chronic migraine

(2013) Amynah A. Pradhan et al.   PAIN

S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma

(2012) Y. Liu et al.   BLOOD

Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma

(2012) A. Estrada-Bernal et al.   NEURO-ONCOLOGY

Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion

(2012) Wenrui Xie et al.   NEUROSCIENCE LETTERS

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

Chronic Migraine: Epidemiology and Disease Burden

(2010) Aubrey N. Manack et al.   Current Pain and Headache Reports

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS

(2009) Laura J. Sim-Selley et al.   JOURNAL OF NEUROCHEMISTRY

Spectrum of illness: Understanding biological patterns and relationships in chronic migraine

(2009) S. K. Aurora   NEUROLOGY

Sphingosine 1-Phosphate Modulates Spinal Nociceptive Processing

(2008) Ovidiu Coste et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat

(2008) Elisa Dominguez et al.   JOURNAL OF NEUROCHEMISTRY