ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

(2020) Menggui Huang et al.   Science Translational Medicine

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

(2020) Cefan Zhou et al.   Molecular Cancer

Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer

(2020) Elizabeth Varghese et al.   Cancers

Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates

(2020) Nan Wang et al.   CELL

B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2

(2019) Tongguo Shi et al.   Cell Death & Disease

Circulating biomarkers for early detection and clinical management of colorectal cancer

(2019) María Marcuello et al.   MOLECULAR ASPECTS OF MEDICINE

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis

(2019) Peiwei Huangyang et al.   Cell Metabolism

The prognostic role of circulating tumor cells in colorectal cancer

(2019) Lahiri Kanth Nanduri et al.   Expert Review of Anticancer Therapy

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway

(2018) Yen-Hsiu Yeh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PTBP1 knockdown overcomes the resistance to vincristine and oxaliplatin in drug-resistant colon cancer cells through regulation of glycolysis

(2018) Chuanyao Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation

(2018) M.S. Gilardini Montani et al.   Autophagy

Early redox activities modulate Xenopus tail regeneration

(2018) Fernando Ferreira et al.   Nature Communications

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

(2017) Luisa Iommarini et al.   Frontiers in Oncology

Identification of Targets of the HIF-1 Inhibitor IDF-11774 Using Alkyne-Conjugated Photoaffinity Probes

(2016) Hyun Seung Ban et al.   BIOCONJUGATE CHEMISTRY

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

PI3K inhibitor LY294002, as opposed to wortmannin, enhances AKT phosphorylation in gemcitabine-resistant pancreatic cancer cells

(2016) Yufeng Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Amplification of USP13 drives ovarian cancer metabolism

(2016) Cecil Han et al.   Nature Communications

Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling

(2016) So-Young Hwang et al.   Cell Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

(2015) Emily D. Montal et al.   MOLECULAR CELL

Intensive follow-up strategies improve outcomes in nonmetastatic colorectal cancer patients after curative surgery: a systematic review and meta-analysis

(2014) S. Pita-Fernandez et al.   ANNALS OF ONCOLOGY

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells

(2014) Y. Wang et al.   BLOOD

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

Genetic Markers of Toxicity From Capecitabine and Other Fluorouracil-Based Regimens: Investigation in the QUASAR2 Study, Systematic Review, and Meta-Analysis

(2014) Dan Rosmarin et al.   JOURNAL OF CLINICAL ONCOLOGY

Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma

(2014) Robert T. Wicks et al.   NEURO-ONCOLOGY

Lactic Acidosis

(2014) Jeffrey A. Kraut et al.   NEW ENGLAND JOURNAL OF MEDICINE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide

(2014) Yulia G. Ermakova et al.   Nature Communications

Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway

(2013) Zhiqiang Zhao et al.   CANCER LETTERS

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

(2012) Z. Unnisa et al.   BLOOD

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

(2010) Hua-shan Shi et al.   CANCER SCIENCE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism