RANKL Blockade Reduces Cachexia and Bone Loss Induced by Non‐Metastatic Ovarian Cancer in Mice

Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia

(2021) Joseph E. Rupert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Non-bone metastatic cancers promote osteocyte-induced bone destruction

(2021) Fabrizio Pin et al.   CANCER LETTERS

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice

(2020) Dounia Hamoudi et al.   HUMAN MOLECULAR GENETICS

Muscle loss during primary debulking surgery and chemotherapy predicts poor survival in advanced‐stage ovarian cancer

(2020) Chueh‐Yi Huang et al.   Journal of Cachexia Sarcopenia and Muscle

Muscle-organ crosstalk: the emerging roles of myokines

(2020) Mai Charlotte Krogh Severinsen et al.   ENDOCRINE REVIEWS

TNF Receptor‐Associated Factor 6 Mediates TNFα ‐Induced Skeletal Muscle Atrophy in Mice During Aging

(2020) Jinbo Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pros and Cons of Denosumab Treatment for Osteoporosis and Implication for RANKL Aptamer Therapy

(2020) Ning Zhang et al.   Frontiers in Cell and Developmental Biology

Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia

(2020) Joshua R. Huot et al.   JCI Insight

ACVR2B antagonism as a countermeasure to multi‐organ perturbations in metastatic colorectal cancer cachexia

(2020) Joshua R. Huot et al.   Journal of Cachexia Sarcopenia and Muscle

Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody

(2019) Roger von Moos et al.   CANCER TREATMENT REVIEWS

An anti-RANKL treatment reduces muscle inflammation and dysfunction and strengthens bone in dystrophic mice

(2019) Dounia Hamoudi et al.   HUMAN MOLECULAR GENETICS

RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass

(2019) Nicolas Bonnet et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Impact of RANK Signalling in Ovarian Cancer

(2019) Verena Wieser et al.   Cancers

Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients

(2019) Fabrizio Pin et al.   Frontiers in Endocrinology

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice

(2019) Alyson L. Essex et al.   Frontiers in Endocrinology

Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis

(2018) X. Zhang et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Sarcopenia and Skeletal Muscle Quality as Predictors of Postoperative Complication and Early Mortality in Gynecologic Cancer

(2018) Nathália Silva de Paula et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia

(2018) Fabrizio Pin et al.   Journal of Cachexia Sarcopenia and Muscle

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy

(2018) Sébastien S. Dufresne et al.   Acta Neuropathologica Communications

Sarcopenia in Advanced Serous Ovarian Cancer

(2017) Holger Bronger et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass

(2017) Rafael Barreto et al.   Scientific Reports

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

(2016) Sébastien S. Dufresne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MultiQC: summarize analysis results for multiple tools and samples in a single report

(2016) Philip Ewels et al.   BIOINFORMATICS

RANK-RANKL signalling in cancer

(2016) N. Renema et al.   BIOSCIENCE REPORTS

Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo

(2016) Laura E. Wright et al.   Oncotarget

In vivo tumor growth of high-grade serous ovarian cancer cell lines

(2015) Anirban K. Mitra et al.   GYNECOLOGIC ONCOLOGY

Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading

(2015) Lilian I. Plotkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

(2015) Jinhu Xiong et al.   PLoS One

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

NGSUtils: a software suite for analyzing and manipulating next-generation sequencing datasets

(2013) Marcus R. Breese et al.   BIOINFORMATICS

Elevated expression of activins promotes muscle wasting and cachexia

(2013) Justin L. Chen et al.   FASEB JOURNAL

Nutritional status, CT body composition measures and survival in ovarian cancer

(2013) Michelle L. Torres et al.   GYNECOLOGIC ONCOLOGY

Pamidronate Attenuates Muscle Loss After Pediatric Burn Injury

(2013) Elisabet Børsheim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Novel Genetic Models of Osteoporosis by Overexpression of Human RANKL in Transgenic Mice

(2013) Vagelis Rinotas et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research

(2013) Michael S. Anglesio et al.   PLoS One

Evaluating cell lines as tumour models by comparison of genomic profiles

(2013) Silvia Domcke et al.   Nature Communications

Mitochondrial and sarcoplasmic reticulum abnormalities in cancer cachexia: Altered energetic efficiency?

(2012) Cibely Cristine Fontes-Oliveira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Bone as an Endocrine Organ

(2012) Anyonya Guntur et al.   Endocrine Practice

Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin

(2012) X. Luan et al.   JOURNAL OF IMMUNOLOGY

Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression

(2011) Wing-Yee Cheung et al.   BONE

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

(2010) Pradyut K. Paul et al.   JOURNAL OF CELL BIOLOGY

Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases

(2010) Daniele Santini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RANK/RANKL: Regulators of Immune Responses and Bone Physiology

(2009) Andreas Leibbrandt et al.   Annals of the New York Academy of Sciences

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care

(2008) Marina Mourtzakis et al.   Applied Physiology Nutrition and Metabolism

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL*

(2008) Paul J Kostenuik et al.   JOURNAL OF BONE AND MINERAL RESEARCH