Review
Pharmacology & Pharmacy
Mikkel Bo Brent
Summary: Animal models are crucial for studying the pathophysiology of bone loss and testing pharmaceutical interventions. The review highlights the importance of studying bone loss from perspectives other than post-menopausal osteoporosis and discusses the current landscape of pharmaceutical countermeasures.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Honglei Kang, Qian Guo, Yimin Dong, Renpeng Peng, Kehan Song, Jia Wang, Haiyang Liu, Meipeng Zhu, Hongjian Zhao, Hanfeng Guan, Feng Li
Summary: MAT2A is crucial for osteoclastogenesis and may be a potential therapeutic target for the treatment of osteoporosis.
Article
Endocrinology & Metabolism
Nurgul Imangali, Viktoriya Sokolova, Kathrin Kostka, Matthias Epple, Christoph Winkler
Summary: Calcium phosphate (CaP) is the inorganic part of hard tissues and has a high biocompatibility and good biodegradability. In this study, CaP nanoparticles functionalized with DNA encoding bone anabolic factors were used to modulate osteoclast activity in a genetically modified medaka fish model. The results showed that the functionalized CaP nanoparticles efficiently delivered the inhibitory factor Opgb to osteoclasts and delayed or reduced the occurrence of osteoporosis-like phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yin Cheng, Haixia Liu, Jing Li, Yujie Ma, Changheng Song, Yuhan Wang, Pei Li, Yanjing Chen, Zhiguo Zhang
Summary: Monascin was found to inhibit osteoclastogenesis in RANKL-induced RAW264.7 cells by suppressing MAPKs signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Zhebin Chen, Dasong Liu, Xue Tang, Ying Cui, Wei Hu, Joe M. Regenstein, Peng Zhou
Summary: Sea cucumber enzymatic hydrolysates (SCEH) can inhibit osteoclast generation via the NF-kappa B pathway, reduce inflammation related to osteoporosis, and improve bone metabolism, thereby increasing bone density and relieving osteoporosis.
Article
Medicine, Research & Experimental
Zhen Cao, Xuben Niu, Maihuan Wang, Siwang Yu, Mingkun Wang, Silong Mu, Chuan Liu, Yaxi Wang
Summary: AB4 can inhibit osteoclast differentiation and function by activating Nrf2, making it a potential candidate drug for treating osteoporosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bin Teng, Anjaneyulu Udduttula, Aynur Ismayil, Xinyue Huang, Junfeng Li, Pei-Yi Zhao, Goher Kerem, Jing Long, Chang Liu, Pei-Gen Ren
Summary: This study compares the use of murine cervical vertebrae and lumbar vertebrae for assessing osteoporosis. The results show that the cervical spine is more suitable for early-stage evaluation of osteoporosis, with earlier bone loss and worse mechanical properties.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Orthopedics
Guanghao Chi, Longshun Qiu, Jian Ma, Wei Wu, Yuxin Zhang
Summary: Our meta-analysis study supports that OPG and RANKL are important modulatory factors in bone formation and resorption during bone turnover. Although the serum levels of OPG and RANKL are not associated with osteoporosis, the OPG/RANKL ratio is associated with osteoporosis. Standardizing the test method and unit would be beneficial for clinical application.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Francois Robin, Daniel Chappard, Patricia Leroyer, Chloe Latour, Guillaume Mabilleau, Valerie Monbet, Thibault Cavey, Mathieu Horeau, Frederic Derbre, Marie-Paule Roth, Martine Ropert, Pascal Guggenbuhl, Olivier Loreal
Summary: This study investigates the respective roles of iron excess and hepcidin in the development of iron-related osteoporosis. The findings suggest that iron overload alone is not sufficient to induce osteoporosis, and low levels of hepcidin also contribute to its development.
Article
Cell & Tissue Engineering
M. H. Kim, L. Y. Choi, J. Y. Chung, E-J Kim, W. M. Yang
Summary: In this study, the potential therapeutic effect of auraptene on osteoporosis and its underlying mechanism were investigated using network pharmacology and experimental osteoporotic mice. The results showed that auraptene could ameliorate bone loss in osteoporosis by downregulating the RANKL/NFATc1 pathway and inhibiting osteoclastic activity. This study contributes to the identification of potential therapeutic agents for the treatment of osteoporosis.
BONE & JOINT RESEARCH
(2022)
Article
Medicine, General & Internal
Margarita Ivanova, Julia Dao, Lauren Noll, Jacqueline Fikry, Ozlem Goker-Alpan
Summary: This study found that TRAP5b levels were elevated in GD patients and correlated with GD biomarkers. Additionally, an increase in RANKL and RANKL/OPG ratio was associated with osteopenia in GD, suggesting that TRAP5b may be a potential biomarker for bone disorders in GD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Anne Sophie Solling, Torben Harslof, Niklas Rye Jorgensen, Bente Langdahl
Summary: In patients discontinuing long-term denosumab, RANKL levels are initially high and then decrease, while TRAcP 5b levels increase. This suggests that accumulated RANKL leads to increased activity of osteoclasts.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Plant Sciences
Mi Hye Kim, Haesu Lee, In Jin Ha, Woong Mo Yang
Summary: ZP administration in osteoporotic mice resulted in increased bone mineral density, restoration of serum bone biomarker levels, decreased osteoclast counts, and inhibition of osteoclast formation. These findings suggest that ZP may be a potential therapeutic agent for osteoporosis.
Article
Engineering, Biomedical
Javier Martinez-Reina, Jose Luis Calvo-Gallego, Peter Pivonka
Summary: Drug holidays for postmenopausal osteoporosis patients treated with denosumab may lead to relapse of bone resorption and loss of bone density. Resuming treatment effectively restores bone density, but there is a potential risk of fractures during the drug holiday that needs to be considered.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yongzhi Cui, Bin Lv, Zhongying Li, Chunming Ma, Zhengwei Gui, Yongtao Geng, Guohui Liu, Linchao Sang, Chen Xu, Qi Min, Li Kong, Zhiping Zhang, Yang Liu, Xiangbei Qi, Dehao Fu
Summary: This study presents a novel approach for the treatment of postmenopausal osteoporosis (PMOP) by using genetically engineered nanogels that target bone tissue and inhibit bone resorption while promoting bone formation. The nanogels effectively scavenge RANKL and release therapeutic PTH 1-34 in response to the acidic microenvironment created by osteoclasts. The results show promising therapeutic effects in a mouse model, suggesting the potential for clinical application.
Editorial Material
Endocrinology & Metabolism
Serge Ferrari
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemical Research Methods
Vasiliki-Iris Perivolidi, Foteini Violitzi, Elisavet Ioannidou, Vagelis Rinotas, George Stamatakis, Martina Samiotaki, George Panayotou, Eleni Douni
Summary: This study identified the interactome of SLC2SA46, a mitochondrial protein, and found that it interacts with multiple proteins involved in mitochondrial architecture, energy production, and inter-organellar contacts. Tissue-specific enrichment of interactors was observed.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Endocrinology & Metabolism
Felicia Cosman, David L. Kendler, Bente L. Langdahl, Benjamin Z. Leder, E. Michael Lewiecki, Akimitsu Miyauchi, Maria Rojeski, Michele McDermott, Mary K. Oates, Cassandra E. Milmont, Cesar Libanati, Serge Ferrari
Summary: This analysis evaluated the impact of treatment sequence on the response to romosozumab. The findings suggest that initiating treatment with romosozumab followed by an antiresorptive agent leads to greater increases in bone mineral density and higher response rates.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
E. H. S. Koy, A. Amouzougan, E. Biver, R. Chapurlat, T. Chevalley, S. L. Ferrari, A. Fouilloux, H. Locrelle, H. Marotte, M. Normand, R. Rizzoli, L. Vico, T. Thomas
Summary: This study presents reference values of HR-pQCT measurements in a Franco-Swiss female cohort at the distal radius and tibia sites, considering specific age bounds. Microarchitectural parameters start to decline before the age of 30, with the optimal bone profile observed between the ages of 22 to 27 in this population.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Maria Fusaro, Francesco Tondolo, Lorenzo Gasperoni, Giovanni Tripepi, Mario Plebani, Martina Zaninotto, Thomas L. Nickolas, Markus Ketteler, Andrea Aghi, Cristina Politi, Gaetano La Manna, Maria Luisa Brandi, Serge Ferrari, Maurizio Gallieni, Maria Cristina Mereu, Giuseppe Cianciolo
Summary: This review discusses the mechanism of action of vitamin K and its implications in cardiovascular disease, bone fractures, and inflammation. It highlights the protective role of vitamin K, especially in chronic kidney disease (CKD), and emphasizes the importance of vitamin K dosage in reducing bone fractures and improving vascular calcifications.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Surgery
Nikola Saulacic, Gordana Vunjak-Novakovic, Maiko Haga-Tsujimura, Ken Nakahara, Maude Coline Gerbaix, Serge Livio Ferrari
Summary: The study aimed to evaluate the benefit of periosteal distraction osteogenesis (PDO) on de novo bone formation in rats. The results showed that bone volumes significantly increased in both the periosteal pumping (PP) group and the PDO group, with different degrees of maturity at different time points.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Nutrition & Dietetics
Maria Papageorgiou, Fanny Merminod, Serge Ferrari, Rene Rizzoli, Emmanuel Biver
Summary: This study examined the relationship between calcium intake from various sources and blood lipids in community-dwelling elderly individuals. The results showed that increasing total calcium intake was associated with lower risks of high total cholesterol, triglycerides, and low HDL-cholesterol. Specifically, calcium from dairy products, especially milk and milk-based desserts, was linked to a lower risk of high total cholesterol. Higher calcium intakes from total dairies, milk, and non-fermented dairies were associated with a lower risk of hypertriglyceridemia. No association was found between calcium from non-dairy sources, cheese, or high-fat dairies and blood lipids. Increasing calcium intake through supplements was associated with lower risks of hypertriglyceridemia and low HDL-cholesterol. However, this association was no longer significant after adjusting for other factors.
Review
Nutrition & Dietetics
Maria Fusaro, Giulia Vanessa Re Sarto, Maurizio Gallieni, Laura Cosmai, Piergiorgio Messa, Maurizio Rossini, Iacopo Chiodini, Mario Plebani, Pieter Evenepoel, Nicholas Harvey, Serge Ferrari, Jorge Cannata-Andia, Andrea Trombetti, Maria Luisa Brandi, Markus Ketteler, Thomas L. Nickolas, John Cunningham, Syazrah Salam, Carlo Della Rocca, Aldo Scarpa, Salvatore Minisola, Fabio Malberti, Filomena Cetani, Mario Cozzolino, Sandro Mazzaferro, Luigi Morrone, Giovanni Tripepi, Martina Zaninotto, Maria Cristina Mereu, Maura Ravera, Giuseppe Cianciolo, Gaetano La Manna, Andrea Aghi, Sandro Giannini, Luca Dalle Carbonare
Summary: Bone biopsy with histomorphometric analysis is the gold standard for diagnosing and classifying renal osteodystrophy. However, its use has declined due to various reasons. This position paper from Italian scientific societies aims to promote the use of bone biopsy and improve the management and prognosis of CKD patients through optimization and standardization of the procedure, establishment of a network, and reimbursement adjustments.
Review
Endocrinology & Metabolism
Lorenz C. Hofbauer, Bjoern Busse, Richard Eastell, Serge Ferrari, Morten Frost, Ralph Mueller, Andrea M. Burden, Fernando Rivadeneira, Nicola Napoli, Martina Rauner
Summary: Increased fracture risk is a serious complication of diabetes, leading to prolonged immobility and hospitalizations that can result in significant morbidity and mortality. In type 1 diabetes, bone mass and strength are reduced, leading to a five-fold increased risk of lifelong fractures. In type 2 diabetes, fracture risk is increased despite normal bone mass. The fragility of bones in diabetes can be attributed to cellular abnormalities, matrix interactions, immune and vascular changes, and musculoskeletal maladaptation to chronic hyperglycemia.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amelie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D. Zajac, Rachel A. Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J. M. Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo
Summary: The anti-inflammatory protein A20 plays a critical role in inhibiting NF-kappa B signaling and inflammation. Deficiency of A20 can lead to osteoporosis without causing inflammatory arthritis. A20 regulates RANK-induced NF-kappa B signaling through its specific domains, controlling osteoclast differentiation and bone development.
Article
Endocrinology & Metabolism
Maria Papageorgiou, Emmanuel Biver, Julie Mareschal, Nicholas Edward Phillips, Alexandra Hemmer, Emma Biolley, Nathalie Schwab, Emily N. C. Manoogian, Elena Gonzalez Rodriguez, Daniel Aeberli, Didier Hans, Caroline Pot, Satchidananda Panda, Nicolas Rodondi, Serge L. Ferrari, Tinh-Hai Collet
Summary: This study investigated the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health. The results showed that TRE had no detrimental effects on bone health in the overall population, but in weight loss responders, it was associated with some bone-sparing effects compared with SDA.
Article
Endocrinology & Metabolism
Francesca Marini, Francesca Giusti, Elena Marasco, Luciano Xumerle, Katarzyna Malgorzata Kwiatkowska, Paolo Garagnani, Emmanuel Biver, Serge Ferrari, Giovanni Iolascon, Teresa Iantomasi, Maria Luisa Brandi
Summary: Atypical femur fractures (AFFs) are rare fractures that occur at the lateral cortex of the femur and are associated with rare genetic bone disorders and long-term use of antiresorption drugs. Genetic screening of unrelated patients with AFFs revealed a high frequency of rare variants in the SLC34A1 and SLC9A3R1 genes, suggesting a possible genetic risk factor for AFFs.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Rheumatology
Serge Ferrari, Bente Langdahl
Summary: Denosumab, a human monoclonal antibody against RANKL, inhibits osteoclast differentiation and activity, leading to anti-resorptive properties and anti-fracture efficacy. Compared with bisphosphonates, denosumab results in continuous bone mineral density gain during long-term treatment and rapid bone loss upon withdrawal. The underlying mechanisms for these effects are not fully understood, but emerging data suggest that denosumab may affect both osteoclasts and osteoblasts, causing sustained bone gain and bone loss. Future studies and clinical implications are discussed in this Perspective.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
J. A. Kanis, H. Johansson, E. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -c. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -p. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, L. Vandenput, N. C. Harvey, M. Lorentzon, W. D. Leslie
Summary: A large international meta-analysis finds that a previous history of fracture is associated with an increased risk of future fractures, regardless of age, sex, and bone mineral density. The study highlights the importance of considering previous fracture history as a risk factor for fracture prevention strategies.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Eleni Tsiantouli, Emmanuel Biver, Thierry Chevalley, Robert Petrovic, Didier Hannouche, Serge Ferrari
Summary: Hypophosphatasia (HPP) is a rare genetic disorder characterized by low serum alkaline phosphatase (ALP). This study found that low ALP values are common in patients with atypical femoral fractures (AFF) and are mainly related to antiresorptive medication. Therefore, low serum ALP has low specificity for HPP among AFF patients.
CALCIFIED TISSUE INTERNATIONAL
(2022)