Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

An Update on Human Stem Cell-Based Therapy in Parkinson';s Disease

(2016) Clara González et al.   Current Stem Cell Research & Therapy

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo

(2015) Sylvie Burnouf et al.   ACTA NEUROPATHOLOGICA

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective

(2015) Matthew Baumgart et al.   Alzheimers & Dementia

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

Current advances in the generation of human iPS cells: implications in cell-based regenerative medicine

(2015) Ana Revilla et al.   Journal of Tissue Engineering and Regenerative Medicine

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation

(2015) R Shu et al.   Cell Death & Disease

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

(2015) Hye Yun Kim et al.   Nature Communications

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Dissecting Alzheimer disease in Down syndrome using mouse models

(2015) Xun Yu Choong et al.   Frontiers in Behavioral Neuroscience

Timing of therapies for Down syndrome: the sooner, the better

(2015) Fiorenza Stagni et al.   Frontiers in Behavioral Neuroscience

Autosomal Dominant Alzheimer Disease: A Unique Resource to Study CSF Biomarker Changes in Preclinical AD

(2015) Suzanne Elizabeth Schindler et al.   Frontiers in Neurology

Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway

(2014) Young-Don Kwak et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amyloid precursor protein and neural development

(2014) M. Nicolas et al.   DEVELOPMENT

Stem and progenitor cell dysfunction in human trisomies

(2014) B. Liu et al.   EMBO REPORTS

Neurogenin 2 Mediates Amyloid-β Precursor Protein-stimulated Neurogenesis

(2014) Marta Bolós et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein

(2014) Janice A. Maloney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Dysregulation of protein trafficking in neurodegeneration

(2014) Xin Wang et al.   Molecular Neurodegeneration

APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome

(2014) Stefania Trazzi et al.   NEUROBIOLOGY OF DISEASE

Reconsidering hippocampal neurogenesis in Alzheimer's disease

(2014) Alonso Martinez-Canabal   Frontiers in Neuroscience

Distinct Roles of sAPP-α and sAPP-β in Regulating U251 Cell Differentiation

(2013) Junfeng Jiang et al.   Current Alzheimer Research

The population prevalence of Down’s syndrome in England and Wales in 2011

(2013) Jianhua Wu et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

Role of Cystatin C in Amyloid Precursor Protein-induced Proliferation of Neural Stem/Progenitor Cells

(2013) Yanling Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome

(2013) Stefania Trazzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current Estimate of Down Syndrome Population Prevalence in the United States

(2013) Angela P. Presson et al.   JOURNAL OF PEDIATRICS

Amyloid β Peptides Promote Autophagy-Dependent Differentiation of Mouse Neural Stem Cells

(2013) Maria B. Fonseca et al.   MOLECULAR NEUROBIOLOGY

Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation

(2013) Michael P. Demars et al.   NEUROBIOLOGY OF AGING

The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease

(2013) Anna Sandebring et al.   PLoS One

Progress in Stem Cell Therapy for Major Human Neurological Disorders

(2013) P. L. Martínez-Morales et al.   Stem Cell Reviews and Reports

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

(2013) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening

(2012) Maria Loane et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Down syndrome: the brain in trisomic mode

(2012) Mara Dierssen   NATURE REVIEWS NEUROSCIENCE

Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology

(2012) Elaine K. Perry et al.   NEUROBIOLOGY OF DISEASE

Risk Factors and Preventive Interventions for Alzheimer Disease

(2011) Martha L. Daviglus   ARCHIVES OF NEUROLOGY

Nuclear signalling by membrane protein intracellular domains: The AICD enigma

(2011) Caroline Beckett et al.   CELLULAR SIGNALLING

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation

(2011) Lujia Zhou et al.   EMBO Molecular Medicine

Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells

(2011) Sara Baratchi et al.   HIPPOCAMPUS

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

(2011) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

Soluble Amyloid Precursor Protein Induces Rapid Neural Differentiation of Human Embryonic Stem Cells

(2011) Kristine K. Freude et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo

(2011) Tamara Jefferson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

(2011) Stéphanie Chasseigneaux et al.   JOURNAL OF NEUROCHEMISTRY

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Trisomy 21 and early brain development

(2011) Tarik F. Haydar et al.   TRENDS IN NEUROSCIENCES

The roles of amyloid precursor protein (APP) in neurogenesis

(2011) Zhi-dong Zhou et al.   Cell Adhesion & Migration

Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin

(2011) Michael P Demars et al.   Stem Cell Research & Therapy

The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of Aβ in different brain regions

(2010) Lina Keller et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation

(2010) Young-Don Kwak et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis

(2010) Takeshi Ohkawara et al.   GENE

Stem cells in human neurodegenerative disorders — time for clinical translation?

(2010) Olle Lindvall et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid-β Precursor Protein Induces Glial Differentiation of Neural Progenitor Cells by Activation of the IL-6/gp130 Signaling Pathway

(2010) Young-Don Kwak et al.   NEUROTOXICITY RESEARCH

β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

(2010) Erica Buoso et al.   PHARMACOLOGICAL RESEARCH

APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation

(2010) Kaushik Ghosal et al.   PLoS One

A TAG on to the neurogenic functions of APP

(2010) Quan-Hong Ma et al.   Cell Adhesion & Migration

Enlarged Brain Ventricles and Impaired Neurogenesis in the Ts1Cje and Ts2Cje Mouse Models of Down Syndrome

(2009) Keiichi Ishihara et al.   CEREBRAL CORTEX

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Differential Processing of Amyloid-β Precursor Protein Directs Human Embryonic Stem Cell Proliferation and Differentiation into Neuronal Precursor Cells

(2009) Prashob Porayette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells

(2009) Angel Ayuso-Sacido et al.   JOURNAL OF NEURO-ONCOLOGY

Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains

(2009) Hedvig Welander et al.   JOURNAL OF NEUROCHEMISTRY

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Aβ40 promotes neuronal cell fate in neural progenitor cells

(2008) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET