Chemotherapy-Induced Cognitive Impairment and Hippocampal Neurogenesis: A Review of Physiological Mechanisms and Interventions

Cancer Treatment-Induced Accelerated Aging in Cancer Survivors: Biology and Assessment

(2021) Shuo Wang et al.   Cancers

Cognitive Impairment Resulting from Treatment with Docetaxel, Doxorubicin, and Cyclophosphamide

(2021) Taurean Brown et al.   BRAIN RESEARCH

Formation and integration of new neurons in the adult hippocampus

(2021) Annina Denoth-Lippuner et al.   NATURE REVIEWS NEUROSCIENCE

Role and Therapeutic Potential of Melatonin in Various Type of Cancers

(2021) Sangiliyandi Gurunathan et al.   OncoTargets and Therapy

Melatonin Protects against the Side-Effects of 5-Fluorouracil on Hippocampal Neurogenesis and Ameliorates Antioxidant Activity in an Adult Rat Hippocampus and Prefrontal Cortex

(2021) Kornrawee Suwannakot et al.   Antioxidants

Neurogenesis-dependent transformation of hippocampal engrams

(2021) Sangyoon Y. Ko et al.   NEUROSCIENCE LETTERS

Melatonin as an Adjuvant to Antiangiogenic Cancer Treatments

(2021) Alicia González et al.   Cancers

Animal models of chemotherapy-induced cognitive decline in preclinical drug development

(2021) Jeena John et al.   PSYCHOPHARMACOLOGY

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

(2021) J. Terreros-Roncal et al.   SCIENCE

Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats

(2020) Apiwat Sirichoat et al.   LIFE SCIENCES

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

(2020) Lien D Nguyen et al.   EMBO Molecular Medicine

Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease

(2020) Mazel Mihardja et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat

(2020) Jariya Umka Welbat et al.   BIOCHEMICAL PHARMACOLOGY

Social enrichment attenuates chemotherapy induced pro-inflammatory cytokine production and affective behavior via oxytocin signaling

(2020) William H. Walker et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

(2020) Katleen Van der Gucht et al.   CANCER

Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms

(2020) Joseph Wai-Hin Leung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats

(2020) Ahmet Yardım et al.   GENE

Chemotherapy-induced cognitive impairment (CICI): An overview of etiology and pathogenesis

(2020) Noha M. Mounier et al.   LIFE SCIENCES

Ginsenoside Rg1 Prevents Chemotherapy-Induced Cognitive Impairment: Associations with Microglia-Mediated Cytokines, Neuroinflammation, and Neuroplasticity

(2019) Dong-Dong Shi et al.   MOLECULAR NEUROBIOLOGY

Recalibrating the Relevance of Adult Neurogenesis

(2019) Jason S. Snyder   TRENDS IN NEUROSCIENCES

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Pharmacologic management of cognitive impairment induced by cancer therapy

(2019) Philipp Karschnia et al.   LANCET ONCOLOGY

Melatonin protects against methotrexate-induced memory deficit and hippocampal neurogenesis impairment in a rat model

(2019) Apiwat Sirichoat et al.   BIOCHEMICAL PHARMACOLOGY

Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

(2019) Sara Emad El-Agamy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats

(2019) Salinee Naewla et al.   Nutrients

Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook

(2019) Brennan Olson et al.   Cancers

Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

(2019) Md. Farhad Hossain et al.   MOLECULAR NEUROBIOLOGY

Chemotherapy-induced cognitive impairments: A systematic review of the animal literature

(2019) A. Matsos et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Chemobrain in rats: behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration

(2019) Carolina Vieira et al.   BEHAVIOURAL BRAIN RESEARCH

Age‐dependent brain volume and neuropsychological changes after chemotherapy in breast cancer patients

(2019) Jeroen Blommaert et al.   HUMAN BRAIN MAPPING

Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors

(2019) M Lange et al.   ANNALS OF ONCOLOGY

Compound K attenuated hepatectomy-induced post-operative cognitive dysfunction in aged mice via LXRα activation

(2019) Qifang Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Lithium treatment reverses irradiation-induced changes in rodent neural progenitors and rescues cognition

(2019) Giulia Zanni et al.   MOLECULAR PSYCHIATRY

Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy

(2019) Li-Tao Yi et al.   NEUROBIOLOGY OF DISEASE

The Effect of Exercise on Cancer-Related Cognitive Impairment and Applications for Physical Therapy: Systematic Review of Randomized Controlled Trials

(2019) Kristin L Campbell et al.   PHYSICAL THERAPY

Cognitive Effects of Cancer and Cancer Treatments

(2018) Tim A. Ahles et al.   Annual Review of Clinical Psychology

Changes in cognition and dendritic complexity following intrathecal methotrexate and cytarabine treatment in a juvenile murine model

(2018) Tyler C. Alexander et al.   BEHAVIOURAL BRAIN RESEARCH

Chemotherapy and cognition: International cognition and cancer task force recommendations for harmonising preclinical research

(2018) Gordon Winocur et al.   CANCER TREATMENT REVIEWS

The neuroprotective role of melatonin in neurological disorders

(2018) B. S. Alghamdi   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibiting constitutive neurogenesis compromises long-term social recognition memory

(2018) Ana Raquel Pereira-Caixeta et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Physical exercise prevents cognitive impairment by enhancing hippocampal neuroplasticity and mitochondrial function in doxorubicin-induced chemobrain

(2018) Hye-Sang Park et al.   NEUROPHARMACOLOGY

Neurobiological Mechanisms of Chemotherapy-induced Cognitive Impairment in a Transgenic Model of Breast Cancer

(2018) Gordon Winocur et al.   NEUROSCIENCE

PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats

(2018) Zhi-Gang Jiang et al.   PLoS One

Impaired Recent, but Preserved Remote, Autobiographical Memory in Pediatric Brain Tumor Patients

(2018) Melanie J. Sekeres et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model

(2018) Jariya Welbat et al.   Nutrients

Low dose aspirin blocks breast cancer-induced cognitive impairment in mice

(2018) Adam K. Walker et al.   PLoS One

Inflammatory Cytokines and Comorbidity Development in Breast Cancer Survivors Versus Noncancer Controls: Evidence for Accelerated Aging?

(2017) Catherine M. Alfano et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthesis and Biological Evaluation of Ginsenoside Compound K Derivatives as a Novel Class of LXRα Activator

(2017) Yan Huang et al.   MOLECULES

Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats

(2017) Yoshihisa Kitamura et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The chemotherapeutic agent paclitaxel selectively impairs reversal learning while sparing prior learning, new learning and episodic memory

(2017) Danielle Panoz-Brown et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The Persistence and Transience of Memory

(2017) Blake A. Richards et al.   NEURON

Effect of aerobic exercise on cancer-associated cognitive impairment: A proof-of-concept RCT

(2017) K.L. Campbell et al.   PSYCHO-ONCOLOGY

Abnormal Development of Dendrites in Adult-Born Rat Hippocampal Granule Cells Induced by Cyclophosphamide

(2017) Lin Wu et al.   Frontiers in Cellular Neuroscience

A novel preventive therapy for paclitaxel-induced cognitive deficits: preclinical evidence from C57BL/6 mice

(2017) P Huehnchen et al.   Translational Psychiatry

Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression

(2017) M Egeland et al.   Translational Psychiatry

Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns

(2017) Alexandra C. Apple et al.   NeuroImage-Clinical

The cancer chemotherapeutic agent paclitaxel (Taxol) reduces hippocampal neurogenesis via down-regulation of vesicular zinc

(2017) Bo Eun Lee et al.   Scientific Reports

Overcoming blood brain barrier with a dual purpose Temozolomide loaded Lactoferrin nanoparticles for combating glioma (SERP-17-12433)

(2017) Sonali Kumari et al.   Scientific Reports

Environmental enrichment protects against cognitive impairment following chemotherapy in an animal model.

(2016) Gordon Winocur et al.   BEHAVIORAL NEUROSCIENCE

Neurobiological changes by cytotoxic agents in mice

(2016) R. Seigers et al.   BEHAVIOURAL BRAIN RESEARCH

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

(2016) Catarina Rendeiro et al.   BEHAVIOURAL BRAIN RESEARCH

Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function

(2016) Gabriel S. Chiu et al.   CANCER RESEARCH

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage

(2016) Ansar Karimian et al.   DNA REPAIR

Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction

(2016) Hannah R. Wardill et al.   INTERNATIONAL JOURNAL OF CANCER

Exercise training for neural recovery in a restricted sample of pediatric brain tumor survivors: a controlled clinical trial with crossover of training versus no training

(2016) Lily Riggs et al.   NEURO-ONCOLOGY

Zinc plus cyclo-(His-Pro) promotes hippocampal neurogenesis in rats

(2016) Bo Young Choi et al.   NEUROSCIENCE

Neurogenesis-mediated forgetting minimizes proactive interference

(2016) Jonathan R. Epp et al.   Nature Communications

Long-term cognitive dysfunction in the rat following docetaxel treatment is ameliorated by the phosphodiesterase-4 inhibitor, rolipram

(2015) Charlotte K. Callaghan et al.   BEHAVIOURAL BRAIN RESEARCH

Memory loss in chemotherapy-treated rats is exacerbated in high-interference conditions and related to suppression of hippocampal neurogenesis

(2015) Gordon Winocur et al.   BEHAVIOURAL BRAIN RESEARCH

Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: Possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation

(2015) Yoshihisa Kitamura et al.   BEHAVIOURAL BRAIN RESEARCH

Stem Cell Transplantation Reverses Chemotherapy-Induced Cognitive Dysfunction

(2015) M. M. Acharya et al.   CANCER RESEARCH

Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis

(2015) Alexander Garthe et al.   HIPPOCAMPUS

Cognitive Function in Patients With Colorectal Cancer Who Do and Do Not Receive Chemotherapy: A Prospective, Longitudinal, Controlled Study

(2015) Janette L. Vardy et al.   JOURNAL OF CLINICAL ONCOLOGY

A Critical Period for Experience-Dependent Remodeling of Adult-Born Neuron Connectivity

(2015) Matteo Bergami et al.   NEURON

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

(2015) I. Marques-Aleixo et al.   NEUROSCIENCE

Chemotherapy, cognitive impairment and hippocampal toxicity

(2015) J. Dietrich et al.   NEUROSCIENCE

Adult Neurogenesis in Humans

(2015) Olaf Bergmann et al.   Cold Spring Harbor Perspectives in Biology

Neurogenesis in the Adult Hippocampus

(2015) Gerd Kempermann et al.   Cold Spring Harbor Perspectives in Biology

A New Avenue for Lithium: Intervention in Traumatic Brain Injury

(2014) Peter R. Leeds et al.   ACS Chemical Neuroscience

Effects of voluntary and involuntary exercise on cognitive functions, and VEGF and BDNF levels in adolescent rats

(2014) N Uysal et al.   BIOTECHNIC & HISTOCHEMISTRY

Neurotoxicity in breast cancer survivors ≥10 years post-treatment is dependent on treatment type

(2014) Myrle M. Stouten-Kemperman et al.   Brain Imaging and Behavior

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

(2014) Katherine HM Cox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Changes to Memory Structures in Children Treated for Posterior Fossa Tumors

(2014) Lily Riggs et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

The Regulatory Mechanism of Neurogenesis by IGF-1 in Adult Mice

(2014) Honghua Yuan et al.   MOLECULAR NEUROBIOLOGY

d-Methionine Protects Against Cisplatin-Induced Neurotoxicity in the Hippocampus of the Adult Rat

(2014) Sneha Hinduja et al.   NEUROTOXICITY RESEARCH

Chemobrain Experienced by Breast Cancer Survivors: A Meta-Ethnography Study Investigating Research and Care Implications

(2014) Maryam Hafsah Selamat et al.   PLoS One

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

(2014) K. G. Akers et al.   SCIENCE

Compound K is able to ameliorate the impaired cognitive function and hippocampal neurogenesis following chemotherapy treatment

(2013) Jin-gang Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dysregulation in myelination mediated by persistent neuroinflammation: Possible mechanisms in chemotherapy-related cognitive impairment

(2013) Teresita L. Briones et al.   BRAIN BEHAVIOR AND IMMUNITY

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Hippocampal lesions produce both nongraded and temporally graded retrograde amnesia in the same rat

(2013) Gordon Winocur et al.   HIPPOCAMPUS

Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions

(2013) Zhiyu Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Melatonin on Nervous System Aging: Neurogenesis and Neurodegeneration

(2013) Golmaryam Sarlak et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The short and long term effects of docetaxel chemotherapy on rodent object recognition and spatial reference memory

(2013) Joanna E. Fardell et al.   LIFE SCIENCES

Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: Role of glucose as adjuvant

(2013) M. Dubois et al.   NEUROPHARMACOLOGY

Cisplatin Inhibits Hippocampal Cell Proliferation and Alters the Expression of Apoptotic Genes

(2013) Senthilvelan Manohar et al.   NEUROTOXICITY RESEARCH

Impact of Chemotherapy for Childhood Leukemia on Brain Morphology and Function

(2013) Marina Genschaft et al.   PLoS One

Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats

(2013) Gordon Winocur et al.   PSYCHOPHARMACOLOGY

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

(2012) Jing Wang et al.   Cell Stem Cell

Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy

(2012) L.-A. Christie et al.   CLINICAL CANCER RESEARCH

Curcumin: A Potential Neuroprotective Agent in Parkinson's Disease

(2012) R. B. Mythri et al.   CURRENT PHARMACEUTICAL DESIGN

Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

(2012) Michael W. Marlatt et al.   Developmental Neurobiology

Chemotherapy disrupts learning, neurogenesis and theta activity in the adult brain

(2012) Miriam S. Nokia et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Age-dependent effects of hippocampal neurogenesis suppression on spatial learning

(2012) Alonso Martinez-Canabal et al.   HIPPOCAMPUS

Global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy

(2012) Vincent Koppelmans et al.   HUMAN BRAIN MAPPING

Reactive Oxygen Species and Mitochondrial Sensitivity to Oxidative Stress Determine Induction of Cancer Cell Death by p21

(2012) Ionica Masgras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lithium rescues synaptic plasticity and memory in Down syndrome mice

(2012) Andrea Contestabile et al.   JOURNAL OF CLINICAL INVESTIGATION

The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound

(2012) Juyoung Park et al.   JOURNAL OF CONTROLLED RELEASE

Increasing CRTC1 Function in the Dentate Gyrus during Memory Formation or Reactivation Increases Memory Strength without Compromising Memory Quality

(2012) M. J. Sekeres et al.   JOURNAL OF NEUROSCIENCE

Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity

(2012) Suzhen Dong et al.   PLoS One

Fluoxetine Counteracts the Cognitive and Cellular Effects of 5-Fluorouracil in the Rat Hippocampus by a Mechanism of Prevention Rather than Recovery

(2012) Laura Lyons et al.   PLoS One

Cognitive effects of chemotherapy in breast cancer patients: a dose-response study

(2012) Barbara Collins et al.   PSYCHO-ONCOLOGY

Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region

(2012) Yosuke Niibori et al.   Nature Communications

Neurotoxicity of methotrexate to hippocampal cells in vivo and in vitro

(2011) Miyoung Yang et al.   BIOCHEMICAL PHARMACOLOGY

Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications

(2011) Teresita L Briones et al.   BMC NEUROSCIENCE

The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism

(2011) Asghar Ghorbani et al.   EUROPEAN JOURNAL OF NUTRITION

Pre-Chemotherapy Differences in Visuospatial Working Memory in Breast Cancer Patients Compared to Controls: An fMRI Study

(2011) Carole Scherling et al.   Frontiers in Human Neuroscience

Longitudinal Assessment of Chemotherapy-Induced Structural Changes in Cerebral White Matter and Its Correlation With Impaired Cognitive Functioning

(2011) Sabine Deprez et al.   JOURNAL OF CLINICAL ONCOLOGY

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

(2011) S. S. D. Stone et al.   JOURNAL OF NEUROSCIENCE

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model

(2011) Gordon Winocur et al.   NEUROPHARMACOLOGY

The Effects of Cyclophosphamide on Hippocampal Cell Proliferation and Spatial Working Memory in Rat

(2011) Laura Lyons et al.   PLoS One

Antidepressants Stimulate Hippocampal Neurogenesis by Inhibiting p21 Expression in the Subgranular Zone of the Hipppocampus

(2011) Robert N. Pechnick et al.   PLoS One

The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice

(2010) Christopher M. Mondie et al.   BEHAVIOURAL BRAIN RESEARCH

Carmustine and methotrexate in combination after whole brain radiation therapy in breast cancer patients presenting with brain metastases: a retrospective study

(2010) William Jacot et al.   BMC CANCER

Chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients

(2010) Sabine Deprez et al.   HUMAN BRAIN MAPPING

Fluoxetine Increases Hippocampal Neurogenesis and Induces Epigenetic Factors But Does Not Improve Functional Recovery after Traumatic Brain Injury

(2010) Yonggang Wang et al.   JOURNAL OF NEUROTRAUMA

Dorsal hippocampal CREB is both necessary and sufficient for spatial memory

(2010) M. J. Sekeres et al.   LEARNING & MEMORY

Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: Possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits

(2010) Miyoung Yang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice

(2010) Anna Fiorentini et al.   PLoS One

Running enhances spatial pattern separation in mice

(2010) D. J. Creer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy

(2010) Laura Lyons et al.   PSYCHOPHARMACOLOGY

Social Interaction Prevents the Development of Depressive-Like Behavior Post Nerve Injury in Mice: A Potential Role for Oxytocin

(2010) Greg J. Norman et al.   PSYCHOSOMATIC MEDICINE

A prospective longitudinal study of chemotherapy-induced cognitive changes in breast cancer patients

(2010) Catherine E. Jansen et al.   SUPPORTIVE CARE IN CANCER

Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats

(2009) Riejanne Seigers et al.   BEHAVIOURAL BRAIN RESEARCH

Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil

(2009) Maha ELBeltagy et al.   BEHAVIOURAL BRAIN RESEARCH

Lithium Restores Neurogenesis in the Subventricular Zone of the Ts65Dn Mouse, a Model for Down Syndrome

(2009) Patrizia Bianchi et al.   BRAIN PATHOLOGY

Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor

(2009) Riejanne Seigers et al.   BRAIN RESEARCH BULLETIN

IGF-1 Partially Restores Chemotherapy-Induced Reductions in Neural Cell Proliferation in Adult C57BL/6 Mice

(2009) Michelle C. Janelsins et al.   CANCER INVESTIGATION

Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory

(2009) Takashi Kitamura et al.   CELL

Physical exercise leads to rapid adaptations in hippocampal vasculature: Temporal dynamics and relationship to cell proliferation and neurogenesis

(2009) Karin Van der Borght et al.   HIPPOCAMPUS

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies

(2009) Alexander Garthe et al.   PLoS One

Melatonin maintains adult hippocampal neurogenesis and cognitive functions after irradiation

(2009) Kailash Manda et al.   PROGRESS IN NEUROBIOLOGY

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis

(2008) Sadaharu Kotani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus

(2008) Sarah Mustafa et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The neuroprotective potential of flavonoids: a multiplicity of effects

(2008) David Vauzour et al.   Genes and Nutrition

Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke

(2008) Wen-Lei Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurons born in the adult dentate gyrus form functional synapses with target cells

(2008) Nicolas Toni et al.   NATURE NEUROSCIENCE

Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat

(2007) R SEIGERS et al.   BEHAVIOURAL BRAIN RESEARCH