Article
Plant Sciences
Man Liu, Yucong Zhang, An Zhang, Yuxuan Deng, Xintao Gao, Jiaxin Wang, Yi Wang, Shaogang Wang, Jihong Liu, Shaoyong Chen, Weimin Yao, Xiaming Liu
Summary: In this study, the effect of compound K (CK) on prostate cancer (PCa) was evaluated, and its potential mechanisms were investigated. The results showed that CK inhibited the proliferation and migration of PCa cells and suppressed the cell cycle through the CDK1 pathway. Therefore, CK may be a potential clinical anticancer agent for treating PCa.
Article
Neurosciences
Gen-Lin He, Ze-Ze Wang, Xue-Ting Yu, Ting-Ting Shen, Zhen Luo, Ping Li, Xue Luo, Yu-Long Tan, Peng Gao, Xue-Sen Yang
Summary: The study found that exposure to electromagnetic fields decreases adult hippocampal neurogenesis, but heat acclimation treatment can improve this condition by restoring microglial CX3CR1 expression. Pharmacological inhibition of CX3CR1 and SIRT1 does not rescue CX3CR1 expression or alleviate neurogenesis impairment.
BRAIN RESEARCH BULLETIN
(2021)
Article
Plant Sciences
Metin Turan, Melek Ekinci, Sanem Argin, Mihail Brinza, Ertan Yildirim
Summary: Drought has negative effects on the physiological and biochemical characteristics of crops. This study aimed to investigate the effects of biostimulants containing PGPR on tomato seedlings under different irrigation levels. The results showed that biostimulant applications mitigated the adverse effects of drought stress and improved plant growth parameters. The most effective dose was 4 L ha(-1) under drought conditions.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Immunology
Guo Mu, Qiang Li, Bin Lu, Xuan Yu
Summary: Trigeminal neuralgia (TN) is a complex orofacial neuropathic pain characterized by lightning-like pain. Chronic inflammation and nerve demyelination play a major role in TN. In this study, the intra-intestinal application of a hydrogen-producing Si-based agent demonstrated a reduction in inflammation and neural demyelination in TN rats. Additionally, the mechanism behind the neural effects of the Si-based agent involves the inhibition of microglial pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Abdul Qader, Kanwal Rehman, Muhammad Sajid Hamid Akash
Summary: This study investigated the impairment of lipid metabolism induced by lead (Pb) and its amelioration through plant-based therapeutic interventions. Pb-induced hepatotoxicity disrupted the normal levels of antioxidant enzymes, leading to lipid peroxidation. Additionally, Pb toxicity altered the regulation of hormones involved in the synthesis of HMG-CoA reductase, resulting in abnormal levels of serum cholesterol and other lipid molecules. The administration of resveratrol effectively treated Pb toxicity. Overall, this study demonstrated the therapeutic effect of resveratrol in improving Pb-induced lipid metabolism impairment by using vitamin C as a standard intervention.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Oncology
Alison Lewis, Adnan Nagrial
Summary: Pancreatic adenocarcinoma is a highly aggressive tumor with a high mortality rate. The standard of care for first-line therapy is multi-agent chemotherapy or gemcitabine plus nab-Paclitaxel. This systematic review aims to compare the efficacy of multi-agent versus single-agent chemotherapy in elderly and young populations with advanced pancreatic adenocarcinoma.
Article
Materials Science, Multidisciplinary
Xiao-Xiao Man, Pei -Han Sun, Jian-Feng Zhang, Zhong-Yi Lu, Kai Liu
Summary: Recent experiments have shown that inserting metal atoms or small molecules between the FeSe layers of beta-FeSe can significantly increase the superconducting transition temperature. Based on first-principles calculations, this study proposes a stable compound called SnOFeSe by stacking SnO and beta-FeSe layers alternately. SnOFeSe has a tetragonal structure similar to the well-known FeAs-based compound LaOFeAs, and their electronic structures in the nonmagnetic state are also similar.
Article
Biochemistry & Molecular Biology
Marta Andres-Mach, Aleksandra Szewczyk, Miroslaw Zagaja, Joanna Szala-Rycaj, Marta Kinga Lemieszek, Maciej Maj, Michal Abram, Krzysztof Kaminski
Summary: The study discovered that the new compound C11 has a protective effect on astrocytes in vitro and beneficial effects on neurogenesis and cognitive functions in vivo, indicating the need for further research on its neuroprotective mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Courtney B. Subramaniam, Hannah R. Wardill, Maya R. Davies, Vivien Heng, Marc A. Gladman, Joanne M. Bowen
Summary: The neuropsychological symptoms caused by chemotherapy treatment pose a major challenge due to insufficient understanding of the underlying mechanisms. This study aimed to investigate the neuroimmunological changes following systemic 5-fluorouracil treatment in mice, and found acute neuroinflammatory changes as well as correlations between neurogenesis, glial cells, and gene expression. These findings highlight the importance of early intervention to prevent long-term neuropsychological deficits after chemotherapy.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Manal T. T. Usmani, Robert P. P. Krattli, Sanad M. M. El-Khatib, Anh C. D. Le, Sarah M. M. Smith, Janet E. E. Baulch, Ding Quan Ng, Munjal M. M. Acharya, Alexandre Chan
Summary: Breast cancer patients treated with doxorubicin (ADR) experience reduced levels of BDNF, leading to cognitive impairments. The orally active BDNF-enhancing medication riluzole (RZ) improves hippocampal-dependent learning and memory function, reduces anxiety-like behavior, and protects against neuroinflammation. RZ also prevents chemotherapy-induced reductions in BDNF levels and promotes dentate neurogenesis.
Article
Multidisciplinary Sciences
Xuejiang Zhang, Dazhao Yu, Hua Wang
Summary: The biological agent G15 discovered by the research team alters the microbial community structure in the pepper rhizosphere, reducing pathogenic fungi while increasing beneficial bacteria, ultimately enhancing resistance to pepper root rot and increasing pepper yield.
Article
Chemistry, Physical
Jiaheng Zhang, Yuqian Li, Liping Zhu, Xiuli Wang, Jiangping Tu
Summary: This study utilized a graphite-intercalation-compound of K (K-GIC) as an anode for potassium metal batteries, which effectively suppressed dendrite growth and mitigated volume expansion, leading to improved cycling stability. Additionally, the K-GIC compound exhibited good environmental stability when in contact with air and water, indicating its potential for promoting the application of safe and high-performance potassium metal batteries.
ENERGY STORAGE MATERIALS
(2021)
Review
Medicine, Research & Experimental
Justin Zeien, Wendy Qiu, Mason Triay, Hemangini A. Dhaibar, Diana Cruz-Topete, Elyse M. Cornett, Ivan Urits, Omar Viswanath, Alan David Kaye
Summary: Chemotherapy, a common treatment option for cancer, often causes toxicities in multiple organ systems due to its inability to differentiate between malignant and healthy cells. These toxic effects can be acute, chronic, or even appear long after chemotherapy is finished. Additionally, chemotherapy can significantly impact the anesthetic management of patients undergoing surgery.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Engineering, Civil
Yizhe Chen, Wenfeng Xiang, Qingsong Zhang, Hui Wang, Lin Hua
Summary: This study investigates the surface modification of a nickel plate to improve the bonding strength with carbon fiber-reinforced plastics (CFRP). The results show that different surface modification methods, including sandblasting, coupling agent treatment, and compound coupling agent treatment, significantly enhance the bonding strength of CFRP/Ni joints. The research provides insights into improving the connection between nickel and CFRP, as well as other heterogeneous materials.
THIN-WALLED STRUCTURES
(2024)
Review
Pharmacology & Pharmacy
Simona Serini, Sonia Trombino, Federica Curcio, Roberta Sole, Roberta Cassano, Gabriella Calviello
Summary: Phenolic compounds have various pharmacological activities and are associated with fewer side effects compared to most antitumor drugs. Nanoformulations, including polyphenols in combination with anticancer drugs, are an effective strategy to enhance their stability and bioavailability. The use of hyaluronic acid-based systems for targeted delivery of phenolic compounds to cancer cells has become a researched topic.
Article
Biotechnology & Applied Microbiology
Zhen Wang, Chunyan Wang, Changkeun Sung
BIOCONTROL SCIENCE AND TECHNOLOGY
(2015)
Article
Microbiology
Yun-bo Wang, Wen-xing Pang, Xiao-na Yv, Jing-jie Li, Yong-an Zhang, Chang-keun Sung
JOURNAL OF MICROBIOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Hyun Bae Bang, Yoon Hyeok Lee, Sun Chang Kim, Chang Keun Sung, Ki Jun Jeong
MICROBIAL CELL FACTORIES
(2016)
Article
Microbiology
Y. B. Wang, J. J. Xue, C. Yin, H. H. Wang, B. B. Duan, L. J. Gu, C. K. Sung
Article
Plant Sciences
Evelyn Saba, Bo Ra Jeon, Da-Hye Jeong, Kija Lee, Youn-Kyoung Goo, Seung-Hyung Kim, Chang-Keun Sung, Seong-Soo Roh, Sung Dae Kim, Hyun-Kyoung Kim, Man-Hee Rhee
JOURNAL OF GINSENG RESEARCH
(2016)
Article
Food Science & Technology
Mi Ra Lee, Shahnaz Begum, Chang Keun Sung
FOOD SCIENCE AND BIOTECHNOLOGY
(2017)
Article
Chemistry, Medicinal
Jing-Jie Li, Zheng Li, Li-Juan Gu, Kang-Ju Choi, Dong-Seon Kim, Ho-Kyoung Kim, Chang-Keun Sung
JOURNAL OF NATURAL MEDICINES
(2018)
Article
Biochemistry & Molecular Biology
Jingang Hou, Sunchang Kim, Changkeun Sung, Chulhee Choi
Article
Plant Sciences
Mi Ra Lee, Jin Yeul Ma, Chang Keun Sung
JOURNAL OF GINSENG RESEARCH
(2017)
Article
Genetics & Heredity
Baojun Xu, Qijun Wang, Changkeun Sung
Article
Biotechnology & Applied Microbiology
Chun Yan Wang, Can Yin, Zhe Ming Fang, Zhen Wang, Yun Bo Wang, Jian Jie Xue, Li Juan Gu, Chang Keun Sung
BIOCONTROL SCIENCE AND TECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Jingang Hou, Changhao Cui, Sunchang Kim, Changkeun Sung, Chulhee Choi
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Article
Medicine, Research & Experimental
Shahnaz Begum, Mi Ra Lee, Li Juan Gu, Jamil Hossain, Chang Keun Sung
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2015)
Article
Microbiology
Hai H. Wang, Hong L. Chu, Qing Dou, Qing Z. Xie, Ming Tang, Chang K. Sung, Chun Y. Wang
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Zoology
Zhen Wang, Yongan Zhang, Chunyan Wang, Yunbo Wang, Chungkeun Sung
JOURNAL OF NEMATOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)