Article
Biochemistry & Molecular Biology
Alan Umfress, Haley E. Speed, Chunfeng Tan, Saleh Ramezani, Shari Birnbaum, Rolf A. Brekken, Xiankai Sun, Florian Plattner, Craig M. Powell, James A. Bibb
Summary: Chemotherapy can lead to cognitive impairment in cancer patients, with no effective treatments currently available. A study showed that chronic use of certain chemotherapeutic agents affects metabolism and memory formation in the hippocampus, leading to neuroinflammation. Understanding the pathological consequences of chemotherapy-induced cognitive impairment is crucial for improving cancer treatment outcomes.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Toxicology
Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria Lourdes Bastos, Eduarda Fernandes, Susana Isabel Sa, Joao Paulo Capela, Felix Carvalho, Vera Marisa Costa
Summary: This study evaluated the neurotoxic pathways of mitoxantrone in the brain of adult mice and found that it caused significant damage in regions associated with memory and cognition.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Oncology
Carli Shaw, Adele Baldwin, Carina Anderson
Summary: Despite the rising global cancer incidence, survival rates are improving in developed countries with early detection, improved treatments, and survivorship care. Side effects like cognitive impairment may persist long term after aggressive treatments, although the exact etiology of chemotherapy induced cognitive impairment remains largely unknown.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2021)
Review
Toxicology
Ana Dias-Carvalho, Mariana Ferreira, Rita Ferreira, Maria de Lourdes Bastos, Susana Isabel Sa, Joao Paulo Capela, Felix Carvalho, Vera Marisa Costa
Summary: Chemotherapy-induced cognitive dysfunction has a significant impact on cancer patients, affecting domains such as verbal memory and psychomotor function. Studies suggest that chemotherapy alters brain metabolism, white and grey matter, while the underlying neurotoxic mechanism of cognitive deficits is still not fully elucidated.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Chemistry, Medicinal
M. Skurlova, K. Holubova, L. Kleteckova, T. Kozak, H. Kubova, J. Horacek, K. Vales
Summary: Cancer treatment-induced cognitive impairment, known as chemobrain, has a significant negative impact on patients' well-being and is a current research hot topic. Inflammation and oxidative/nitrosative stress are closely related to blood-brain barrier disruption, leading to neuroinflammation, neurotoxicity, and neurodegeneration. Chemotherapy also affects brain functionality and morphology through alterations in cell properties. Additionally, chemotherapy has unique impacts on immune system functions and metabolism. Overall, inflammation is a possible mechanism for brain damage during blood cancers, and chemotherapy can lead to cognitive impairment.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Medicine, Research & Experimental
Manas Kinra, Niraja Ranadive, Karthik Gourishetti, Pawan Ganesh Nayak, Rajesh N. Jagdale, Syed Mushtaq Ahmed, Kaggundi Raghavendra, Jayesh Mudgal, Krishnadas Nandakumar
Summary: The study evaluated a marketed formulation Mulmina (TM) against chemotherapy-induced cognitive dysfunction. Mulmina (TM) showed significant improvement in cognitive function and biochemical parameters post-chemotherapy in a mouse model, indicating potential for further research into its mechanism of action.
BIOMEDICAL REPORTS
(2021)
Article
Clinical Neurology
Benjamin Ongnok, Thawatchai Khuanjing, Titikorn Chunchai, Patcharapong Pantiya, Sasiwan Kerdphoo, Busarin Arunsak, Wichwara Nawara, Thidarat Jaiwongkam, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study explored the neuroprotective effects of donepezil on a doxorubicin-induced chemobrain model, showing that donepezil can alleviate neurological deficits and pathologies induced by chemotherapy without affecting doxorubicin's anticancer efficacy.
Article
Clinical Neurology
Manal T. T. Usmani, Robert P. P. Krattli, Sanad M. M. El-Khatib, Anh C. D. Le, Sarah M. M. Smith, Janet E. E. Baulch, Ding Quan Ng, Munjal M. M. Acharya, Alexandre Chan
Summary: Breast cancer patients treated with doxorubicin (ADR) experience reduced levels of BDNF, leading to cognitive impairments. The orally active BDNF-enhancing medication riluzole (RZ) improves hippocampal-dependent learning and memory function, reduces anxiety-like behavior, and protects against neuroinflammation. RZ also prevents chemotherapy-induced reductions in BDNF levels and promotes dentate neurogenesis.
Article
Pharmacology & Pharmacy
A. H. Alhowail, M. Aldubayan
Summary: Chemobrain, also known as chemotherapy-induced cognitive impairment, refers to cognitive dysfunction that occurs after chemotherapy. The potential mechanisms of chemobrain include disruptions in hippocampal cell proliferation and neurogenesis, hormonal changes, increased oxidative stress and inflammation, and alterations in synaptic plasticity. While some mechanisms like inflammation and oxidative stress have been extensively studied, others involving mitochondrial dysfunction, estrogen dysregulation, and increased transglutaminase 2 are still unclear and require further investigation.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Philippa A. Jackson, Charlotte Kenney, Joanne Forster, Ellen F. Smith, Rian Elcoate, Bethany Spittlehouse, Jodee Johnson, David O. Kennedy
Summary: This study investigated the effects of low and moderate doses of coffeeberry extract on cognition and mood. The results showed that 100 mg of coffeeberry extract resulted in increased mental fatigue and decreased accuracy on a task of sustained attention. However, no significant effects were found with 300 mg of coffeeberry extract. Therefore, low to moderate doses of coffeeberry extract do not have a beneficial effect on mood, mental and physical energy levels, or cognition.
Article
Immunology
Courtney Cross, Maya Davies, Emma Bateman, Elise Crame, Paul Joyce, Anthony Wignall, Amin Ariaee, Marc A. Gladman, Hannah Wardill, Joanne Bowen
Summary: This study demonstrates that a high fibre diet can alter gut microbiota composition and increase the production of the short-chain fatty acid propionate, thereby reducing neuroinflammation caused by the chemotherapeutic agent 5-fluorouracil (5-FU). The results of this study indicate that dietary fibre has neuroprotective effects in alleviating the neuroimmune changes seen in response to chemotherapy treatment, mediated through the microbiota-gut-brain axis.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Biochemistry & Molecular Biology
Bojana Milutinovic, Rajasekaran Mahalingam, Mayela Mendt, Luis Arroyo, Alexandre Seua, Shruti Dharmaraj, Elizabeth Shpall, Cobi J. J. Heijnen
Summary: The neurotoxic side effects of chemotherapy, such as deficits in attention, memory, and executive functioning, currently lack FDA-approved therapies. This study demonstrated that intranasal treatment with small extracellular vesicles derived from mesenchymal stem cells (MSCs) reversed the cognitive impairments and brain damage induced by cisplatin in mice. The intranasally administered sEVs entered the brain within 30 minutes and restored the abnormalities in mitochondrial morphology, loss of white matter, and synaptic integrity in the hippocampus. Transcriptomic analysis revealed potential pathways involved in the recovery process. The findings suggest that intranasal sEV treatment could be a novel therapeutic approach for chemobrain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ka Young Lim, Seong-Ik Kim, Hyunhee Kim, Jeongwan Kang, Jin Woo Park, Jae Kyung Won, Dong-Yeop Shin, Sung-Hye Park
Summary: This report describes two cases that confirm the clinicopathological features of chemotherapy-induced toxic leukoencephalopathy, emphasizing that chemotherapy drugs other than methotrexate can also cause this disease.
Article
Biochemistry & Molecular Biology
Benjamin Ongnok, Chayodom Maneechote, Titikorn Chunchai, Patcharapong Pantiya, Busarin Arunsak, Wichwara Nawara, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study aimed to explore the therapeutic efficacy of mitochondrial dynamic modulators against Dox-induced chemobrain. The results demonstrated that treatment with mitochondrial dynamic modulators restored cognitive function by rebalancing mitochondrial homeostasis and attenuating oxidative and inflammatory insults.
Article
Chemistry, Multidisciplinary
Qingya Liu, Yi Lu, Yao Xiao, Liping Yuan, Danrong Hu, Ying Hao, Ruxia Han, Jinrong Peng, Zhiyong Qian
Summary: This study found that different formulations of chemotherapeutics have different effects on the integrity of the intestinal barrier and the intestinal microbiota. DTX micelles were shown to cause less damage to the intestinal barrier compared to free DTX, and were associated with higher relative abundance of certain beneficial bacteria. The diversity and composition of the intestinal microbiota may be linked to tumor progression.
Article
Biochemistry & Molecular Biology
C. Greene, J. Kealy, M. M. Humphries, Y. Gong, J. Hou, N. Hudson, L. M. Cassidy, R. Martiniano, V Shashi, S. R. Hooper, G. A. Grant, P. F. Kenna, K. Norris, C. K. Callagha, Md N. Islam, S. M. O'Mara, Z. Najda, S. G. Campbell, J. S Pachter, J. Thomas, N. M. Williams, P. Humphries, K. C. Murphy, M. Campbell
MOLECULAR PSYCHIATRY
(2018)
Article
Immunology
Charlotte K. Callaghan, Jennifer Rouine, Reginald L. Dean, Brian I. Knapp, Jean M. Bidlack, Daniel R. Deaver, Shane M. O'Mara
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Neurosciences
Sally Barlow, Briana Fahey, Kimberley J. Smith, Johannes Passecker, Andrea Della-Chiesa, Vincent Hok, Jennifer S. Day, Charlotte K. Callaghan, Shane M. O'Mara
BRAIN RESEARCH BULLETIN
(2018)
Article
Neurosciences
Johannes Passecker, Md. Nurul Islam, Vincent Hok, Shane M. O'Mara
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Mathias L. Mathiasen, Eman Amin, Andrew J. D. Nelson, Christopher M. Dillingham, Shane M. O'Mara, John P. Aggleton
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Pawel Matulewicz, Katharina Ulrich, Md. Nurul Islam, Mathias L. Mathiasen, John P. Aggleton, Shane M. O'Mara
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Christopher M. Dillingham, Michal M. Milczarek, James C. Perry, Bethany E. Frost, Greg D. Parker, Yaniv Assaf, Frank Sengpiel, Shane M. O'Mara, Seralynne D. Vann
JOURNAL OF NEUROSCIENCE
(2019)
Article
Anatomy & Morphology
Christopher M. Dillingham, Mathias L. Mathiasen, Bethany E. Frost, Marie A. C. Lambert, Emma J. Bubb, Maciej M. Jankowski, John P. Aggleton, Shane M. O'Mara
FRONTIERS IN NEUROANATOMY
(2019)
Review
Neurosciences
Shane M. O'Mara, John P. Aggleton
FRONTIERS IN NEURAL CIRCUITS
(2019)
Review
Neurosciences
John P. Aggleton, Shane M. O'Mara
Summary: Standard models of episodic memory focus on hippocampal-parahippocampal interactions, but recent advances have shown that the anterior thalamic nuclei also play a significant role in memory.
NATURE REVIEWS NEUROSCIENCE
(2022)
Article
Neurosciences
Emanuela Rizzello, Sean K. Martin, Jennifer Rouine, Charlotte Callaghan, Mathias L. Mathiasen, Shane M. O'Mara
Summary: Place cells have been found in the rat claustrum, exhibiting location-dependent responses and being modulated by visual inputs. Remapping of place cells in the claustrum is NMDA receptor-dependent when visual inputs are eliminated from the environment.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Letter
Psychiatry
Shane O'Mara
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2022)
Article
Neurosciences
Lisa Kinnavane, Seralynne D. Vann, Andrew J. D. Nelson, Shane M. O'Mara, John P. Aggleton
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)