Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

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Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data

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Heat stress response in the closest algal relatives of land plants reveals conserved stress signaling circuits

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SCSA: A Cell Type Annotation Tool for Single-Cell RNA-seq Data

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The Roles of CD8+ T Cell Subsets in Antitumor Immunity

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CX3CR1–CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment

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Natural polymorphism of Ym1 regulates pneumonitis through alternative activation of macrophages

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Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

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NO • /RUNX3/kynurenine metabolic signaling enhances disease aggressiveness in pancreatic cancer

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GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

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Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

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(2018) Veit Rothhammer et al.   NATURE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

(2018) Rahul Shinde et al.   NATURE IMMUNOLOGY

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

Microbial tryptophan catabolites in health and disease

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The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment

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Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb

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Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

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Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages

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A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

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Salt-responsive gut commensal modulates TH17 axis and disease

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Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

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Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

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Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

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Tumor macrophages are pivotal constructors of tumor collagenous matrix

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Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

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Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

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FoxO4 Promotes Early Inflammatory Response Upon Myocardial Infarction via Endothelial Arg1Novelty and Significance

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IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells

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The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

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Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

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IFN Regulatory Factor-1 Negatively Regulates CD4+CD25+ Regulatory T Cell Differentiation by Repressing Foxp3 Expression

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Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

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Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein

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Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

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Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

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FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix

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