Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

Application of artificial intelligence in chronic liver diseases: a systematic review and meta-analysis

(2021) Pakanat Decharatanachart et al.   BMC GASTROENTEROLOGY

Imaging Biomarkers of NAFLD, NASH, and Fibrosis

(2021) Veeral Ajmera et al.   Molecular Metabolism

Heterogeneity of hepatic stellate cells in a mouse model of non‐alcoholic steatohepatitis (NASH)

(2021) Sara Brin Rosenthal et al.   HEPATOLOGY

A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH

(2021) Amaro Taylor‐Weiner et al.   HEPATOLOGY

HepQuant SHUNT Detects Portal Hypertension in Early Stages of Clinically Compensated Chronic Liver Disease

(2021) Amanda Wieland et al.   Clinical Gastroenterology and Hepatology

Fibrosis Regression After Eradication of Hepatitis C Virus: From Bench to Bedside

(2021) Don C. Rockey et al.   GASTROENTEROLOGY

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

(2021) Ferenc Emil Mózes et al.   GUT

Ten Thousand Points of Light – Heterogeneity Among the Stars of NASH Fibrosis

(2021) James Carter et al.   HEPATOLOGY

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

(2021) Dominik Pfister et al.   NATURE

Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells

(2021) Julia Vallverdú et al.   Nature Protocols

Role of Angiogenesis in the Pathogenesis of NAFLD

(2021) Lin Lei et al.   Journal of Clinical Medicine

Modeling Diet-Induced NAFLD and NASH in Rats: A Comprehensive Review

(2021) Lydie Carreres et al.   Biomedicines

Organs-on-a-chip models for biological research

(2021) Gordana Vunjak-Novakovic et al.   CELL

Microscopic examination of spatial transcriptome using Seq-Scope

(2021) Chun-Seok Cho et al.   CELL

Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

(2021) Anne Loft et al.   Cell Metabolism

Management of Idiopathic Pulmonary Fibrosis

(2021) Margaret L. Salisbury et al.   CLINICS IN CHEST MEDICINE

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

(2021) Donato Inverso et al.   DEVELOPMENTAL CELL

A Machine Learning Approach to Liver Histological Evaluation Predicts Clinically Significant Portal Hypertension in NASH Cirrhosis

(2021) Jaime Bosch et al.   HEPATOLOGY

Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol

(2021) James M. Eng et al.   Cells

Integrating Spatial Transcriptomics and Single-Cell RNA-seq Reveals the Gene Expression Profling of the Human Embryonic Liver

(2021) Xianliang Hou et al.   Frontiers in Cell and Developmental Biology

Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis

(2021) Arun J. Sanyal et al.   HEPATOLOGY

Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors

(2021) Sophie C. Cazanave et al.   Science Translational Medicine

Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis

(2021) Dipankar Bhattacharya et al.   Scientific Reports

Advances in non-invasive assessment of hepatic fibrosis

(2020) Rohit Loomba et al.   GUT

Review article: the signalling and functional role of the extracellular matrix in the development of liver fibrosis

(2020) Ida Falk Villesen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

(2020) Birgitta E. Michels et al.   Cell Stem Cell

Current and new pharmacotherapy options for non-alcoholic steatohepatitis

(2020) Yoshio Sumida et al.   EXPERT OPINION ON PHARMACOTHERAPY

Why do so many NASH trials fail?

(2020) Vlad Ratziu et al.   GASTROENTEROLOGY

Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis

(2020) Yasaman Vali et al.   JOURNAL OF HEPATOLOGY

STELLAR 3 and STELLAR 4: Lessons from the fall of Icarus

(2020) Mary E. Rinella et al.   JOURNAL OF HEPATOLOGY

Cell-type-resolved proteomic analysis of the human liver

(2020) Magnus Ölander et al.   LIVER INTERNATIONAL

Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis

(2020) Prakash Ramachandran et al.   Nature Reviews Gastroenterology & Hepatology

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

(2020) Tatsuya Tsukui et al.   Nature Communications

Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases

(2020) Eline Geervliet et al.   Cells

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis

(2020) Tae Gyu Oh et al.   Cell Metabolism

Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis

(2020) Guillaume Lassailly et al.   GASTROENTEROLOGY

Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease

(2020) Sonja Lang et al.   GASTROENTEROLOGY

Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology

(2020) Antonio Saviano et al.   JOURNAL OF HEPATOLOGY

Collagen-targeted molecular imaging in diffuse liver diseases

(2020) Iris Y. Zhou et al.   Abdominal Radiology

A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

(2020) Stephen A Harrison et al.   Lancet Gastroenterology & Hepatology

Digital pathology: accurate technique for quantitative assessment of histological features in metabolic-associated fatty liver disease

(2020) David Marti-Aguado et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The application of artificial intelligence for the diagnosis and treatment of liver diseases

(2020) Joseph C Ahn et al.   HEPATOLOGY

Agreement between wedged hepatic venous pressure and portal pressure in non-alcoholic steatohepatitis-related cirrhosis.

(2020) José Ferrusquía-Acosta et al.   JOURNAL OF HEPATOLOGY

Breath Biopsy Assessment of Liver Disease Using an Exogenous Volatile Organic Compound—Toward Improved Detection of Liver Impairment

(2020) Giuseppe Ferrandino et al.   Clinical and Translational Gastroenterology

Artificial intelligence-based pathology for gastrointestinal and hepatobiliary cancers

(2020) Julien Calderaro et al.   GUT

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

(2020) Olivier Govaere et al.   Science Translational Medicine

Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis

(2020) Tingting Su et al.   Cellular and Molecular Gastroenterology and Hepatology

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

(2019) Cyrielle Caussy et al.   Nature Communications

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining Improvement in Nonalcoholic Steatohepatitis for Treatment Trial Endpoints: Recommendations from the Liver Forum

(2019) Amanda Cheung et al.   HEPATOLOGY

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices

(2019) Hannah L. Paish et al.   HEPATOLOGY

Accuracy of imaging methods for steatohepatitis diagnosis in non‐alcoholic fatty liver disease patients: A systematic review

(2019) Giulia Besutti et al.   LIVER INTERNATIONAL

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

(2019) Rie Ouchi et al.   Cell Metabolism

Noninvasive tests accurately identify advanced fibrosis due to NASH : Baseline data from the STELLAR trials

(2019) Quentin M. Anstee et al.   HEPATOLOGY

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Clinical value of serum hyaluronan and propeptide of type III collagen in patients with pancreatic cancer

(2019) Inna M. Chen et al.   INTERNATIONAL JOURNAL OF CANCER

The Versatile Role of Matrix Metalloproteinase for the Diverse Results of Fibrosis Treatment

(2019) Hong-Meng Chuang et al.   MOLECULES

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

(2019) Ross Dobie et al.   Cell Reports

Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition

(2019) Giuseppe Mazza et al.   Cells

The Natural History of Nonalcoholic Fatty Liver Disease—An Evolving View

(2018) Christina C. Lindenmeyer et al.   Clinics in Liver Disease

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

(2018) Giovanni Musso et al.   GASTROENTEROLOGY

Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Zobair M. Younossi et al.   HEPATOLOGY

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Pharmacotherapy for NASH: Current and emerging

(2018) Monica A. Konerman et al.   JOURNAL OF HEPATOLOGY

Matrix metalloproteinase functions in hepatic injury and fibrosis

(2018) Martin Roderfeld   MATRIX BIOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Specialized Proresolving Mediators: Enhancing Nonalcoholic Steatohepatitis and Fibrosis Resolution

(2018) Giovanni Musso et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The role of the microbiome in NAFLD and NASH

(2018) Aleksandra A Kolodziejczyk et al.   EMBO Molecular Medicine

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases

(2017) Benjamin Wooden et al.   GASTROENTEROLOGY

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

(2017) Cristina Alonso et al.   GASTROENTEROLOGY

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

(2017) Francesca Virginia Bruschi et al.   HEPATOLOGY

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

(2017) Soumik BasuRay et al.   HEPATOLOGY

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

(2017) Ryan D Chow et al.   NATURE NEUROSCIENCE

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia

(2017) Chatmanee Lertudomphonwanit et al.   Science Translational Medicine

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

(2017) Daniel F. Hicks et al.   Scientific Reports

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization

(2017) Giuseppe Mazza et al.   Scientific Reports

Portal myofibroblasts connect angiogenesis and fibrosis in liver

(2016) Sara Lemoinne et al.   CELL AND TISSUE RESEARCH

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression

(2016) Steven R. Caliari et al.   Integrative Biology

Potential use of metabolic breath tests to assess liver disease and prognosis: has the time arrived for routine use in the clinic?

(2016) R. Todd Stravitz et al.   LIVER INTERNATIONAL

Endophenotype Network Models: Common Core of Complex Diseases

(2016) Susan Dina Ghiassian et al.   Scientific Reports

Computational and Experimental Advances in Drug Repositioning for Accelerated Therapeutic Stratification

(2015) Khader Shameer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pathophysiology of Liver Fibrosis

(2015) Massimo Pinzani   DIGESTIVE DISEASES

Bone marrow-derived fibrocytes contribute to liver fibrosis

(2015) Jun Xu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MMP Inhibitors Past present and future

(2015) Jian Cao   Frontiers in Bioscience-Landmark

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Liver sinusoidal endothelial cells in hepatic fibrosis

(2015) Laurie D. DeLeve   HEPATOLOGY

Identification of type 2 diabetes subgroups through topological analysis of patient similarity

(2015) Li Li et al.   Science Translational Medicine

Modeling Disease In Vivo With CRISPR/Cas9

(2015) Lukas E. Dow   TRENDS IN MOLECULAR MEDICINE

Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation

(2015) Niklas Verloh et al.   Scientific Reports

Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging

(2015) Dan Li et al.   EJNMMI Research

Reversal, maintenance or progression: What happens to the liver after a virologic cure of hepatitis C?

(2014) Youngmin A. Lee et al.   ANTIVIRAL RESEARCH

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis

(2014) Carlos J Pirola et al.   GUT

Collagen proportionate area is superior to other histological methods for sub-classifying cirrhosis and determining prognosis

(2014) Emmanuel Tsochatzis et al.   JOURNAL OF HEPATOLOGY

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

(2014) Ramona Rudalska et al.   NATURE MEDICINE

Cell and tissue engineering for liver disease

(2014) S. N. Bhatia et al.   Science Translational Medicine

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

(2012) Patrick Marcellin et al.   LANCET

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II

(2011) Raphael Rozenfeld et al.   EMBO JOURNAL

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

(2011) Guanhua Xie et al.   GASTROENTEROLOGY

Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression

(2011) Jingjing Jiao et al.   HEPATOLOGY

Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality

(2011) Zobair M. Younossi et al.   HEPATOLOGY

Fibrosis distribution in explanted cirrhotic livers

(2011) Andrew Hall et al.   HISTOPATHOLOGY

The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells

(2011) Erica Novo et al.   JOURNAL OF PATHOLOGY

Scraping fibrosis: Expressway to the core of fibrosis

(2011) Wajahat Z Mehal et al.   NATURE MEDICINE

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Update on the pathophysiology of liver fibrosis

(2010) Massimo Pinzani et al.   Expert Review of Gastroenterology & Hepatology

Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis

(2009) Guadalupe Garcia-Tsao et al.   HEPATOLOGY

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence

(2008) Laurie D. DeLeve et al.   HEPATOLOGY

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY