Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages

NRF2 Activates Growth Factor Genes and Downstream AKT Signaling to Induce Mouse and Human Hepatomegaly

(2020) Feng He et al.   JOURNAL OF HEPATOLOGY

The Role of the Nrf2 Signaling in Obesity and Insulin Resistance

(2020) Shiri Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Short ELF-EMF Exposure Targets SIRT1/Nrf2/HO-1 Signaling in THP-1 Cells

(2020) Patruno Antonia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling

(2020) Xiaoli Cheng et al.   Biomed Research International

TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis

(2020) Eiji Yoshihara   Antioxidants

High uric acid promotes dysfunction in pancreatic β cells by blocking IRS2/AKT signalling

(2020) Yaqiu Hu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective

(2020) Wei Yu et al.   Frontiers in Pharmacology

Uricase and Horseradish Peroxidase Hybrid CaHPO4 Nanoflower Integrated with Transcutaneous Patches for Treatment of Hyperuricemia

(2019) Ying Hao et al.   Journal of Biomedical Nanotechnology

TXNIP/Redd1 signalling and excessive autophagy: a novel mechanism of myocardial ischaemia/reperfusion injury in mice

(2019) Chao Gao et al.   CARDIOVASCULAR RESEARCH

Gout and hyperuricaemia in the USA: prevalence and trends

(2019) Gurkirpal Singh et al.   RHEUMATOLOGY

Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation

(2019) Qi-Bin Yang et al.   Frontiers in Immunology

High Uric Acid Inhibits Cardiomyocyte Viability Through the ERK/P38 Pathway via Oxidative Stress

(2018) Zhi Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan

(2018) Masanari Kuwabara et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Immobilization rapidly induces thioredoxin-interacting protein (TXNIP) gene expression together with insulin resistance in rat skeletal muscle

(2018) Emi Kawamoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hyperuricemia and endothelial function: From molecular background to clinical perspectives

(2018) Tatsuya Maruhashi et al.   ATHEROSCLEROSIS

Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic DiseasesNovelty and Significance

(2017) Masanari Kuwabara et al.   HYPERTENSION

Uric Acid Is a Strong Risk Marker for Developing Hypertension From PrehypertensionNovelty and Significance

(2017) Masanari Kuwabara et al.   HYPERTENSION

Hyperuricemia is an independent competing risk factor for atrial fibrillation

(2017) Masanari Kuwabara et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells

(2017) Huier Yuan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

“Metabolically Healthy” Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study

(2017) Masanari Kuwabara et al.   Obesity

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress

(2017) Yoko Yagishita et al.   Cell Reports

The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study

(2017) Niels van der Schaft et al.   PLoS One

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle

(2016) Ashok Mandala et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet

(2016) Zhenxiong Liu et al.   Molecular Medicine Reports

High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo

(2016) Li Zhi et al.   PLoS One

High uric acid directly inhibits insulin signalling and induces insulin resistance

(2014) Yuzhang Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Thioredoxin-interacting protein and myocardial mitochondrial function in ischemia–reperfusion injury

(2013) Jun Yoshioka et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

(2012) Akshaya K. Meher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

Nrf2 Represses FGF21 During Long-Term High-Fat Diet-Induced Obesity in Mice

(2011) D. V. Chartoumpekis et al.   DIABETES

TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1

(2011) H-O Jin et al.   ONCOGENE

Deletion of the  -Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

(2010) W. A. Chutkow et al.   DIABETES

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

(2010) Jingbo Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association Between Serum Uric Acid and Development of Type 2 Diabetes

(2009) S. Kodama et al.   DIABETES CARE