Deoxynivalenol: Mechanisms of action and its effects on various terrestrial and aquatic species

Impaired Performance of Broiler Chickens Fed Diets Naturally Contaminated with Moderate Levels of Deoxynivalenol

(2021) Regiane R. Santos et al.   Toxins

Effects of deoxynivalenol on mitochondrial dynamics and autophagy in pig spleen lymphocytes

(2020) Zhihua Ren et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of Deoxynivalenol and Zearalenone on the Histology and Ultrastructure of Pig Liver

(2020) Natalia Skiepko et al.   Toxins

Effects of Deoxynivalenol-Contaminated Diets on Productive, Morphological, and Physiological Indicators in Broiler Chickens

(2020) Insaf Riahi et al.   Animals

Effect of long-term feeding of graded levels of deoxynivalenol (DON) on growth performance, nutrient utilization, and organ health in finishing pigs and DON content in biological samples

(2020) Michael O Wellington et al.   JOURNAL OF ANIMAL SCIENCE

The effects of naturally occurring or purified deoxynivalenol (DON) on growth performance, nutrient utilization and histopathology of rainbow trout (Oncorhynchus mykiss)

(2019) Jamie M. Hooft et al.   AQUACULTURE

A comparative investigation of the effects of feed-borne deoxynivalenol (DON) on growth performance, nutrient utilization and metabolism of detoxification in rainbow trout (Oncorhynchus mykiss) and Nile tilapia (Oreochromis niloticus) fed diets containing different levels of digestible carbohydrates

(2019) Jamie M. Hooft et al.   AQUACULTURE

Feeding of deoxynivalenol increases the intestinal paracellular permeability of broiler chickens

(2019) Wageha A. Awad et al.   ARCHIVES OF TOXICOLOGY

Global Mycotoxin Occurrence in Feed: A Ten-Year Survey

(2019) Christiane Gruber-Dorninger et al.   Toxins

Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production

(2019) Ruifen Kang et al.   ENVIRONMENTAL POLLUTION

Deoxynivalenol induces apoptosis and disrupts cellular homeostasis through MAPK signaling pathways in bovine mammary epithelial cells

(2019) Jin-Young Lee et al.   ENVIRONMENTAL POLLUTION

The toxic effects and potential mechanisms of deoxynivalenol on the structural integrity of fish gill: Oxidative damage, apoptosis and tight junctions disruption

(2019) Chen Huang et al.   TOXICON

Impact of deoxynivalenol on rainbow trout: Growth performance, digestibility, key gene expression regulation and metabolism

(2018) Rui A. Gonçalves et al.   AQUACULTURE

Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp ( Ctenopharyngodon idella )

(2018) Chen Huang et al.   FISH & SHELLFISH IMMUNOLOGY

The Effects of Deoxynivalenol and Zearalenone on the Pig Large Intestine. A Light and Electron Microscopy Study

(2018) Barbara Przybylska-Gornowicz et al.   Toxins

Molecular and Physiological Effects on the Small Intestine of Weaner Pigs Following Feeding with Deoxynivalenol-Contaminated Feed

(2018) J. Pasternak et al.   Toxins

Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar)

(2018) Aksel Bernhoft et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary Deoxynivalenol (DON) May Impair the Epithelial Barrier and Modulate the Cytokine Signaling in the Intestine of Atlantic Salmon (Salmo salar)

(2018) Torfinn Moldal et al.   Toxins

Deoxynivalenol decreased intestinal immune function related to NF-κB and TOR signalling in juvenile grass carp (Ctenopharyngodon idella)

(2018) Chen Huang et al.   FISH & SHELLFISH IMMUNOLOGY

An acute challenge with a deoxynivalenol-contaminated diet has short- and long-term effects on performance and feeding behavior in finishing pigs1

(2018) Aira Maye Serviento et al.   JOURNAL OF ANIMAL SCIENCE

Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar)

(2017) Aksel Bernhoft et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Occurrence and potential transfer of mycotoxins in gilthead sea bream and Atlantic salmon by use of novel alternative feed ingredients

(2015) Jaime Nácher-Mestre et al.   CHEMOSPHERE

Deoxynivalenol alone or in combination with nivalenol and zearalenone induce systemic histological changes in pigs

(2015) Juliana R. Gerez et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The effect of mycotoxin deoxynivalenol (DON) on the oxidative stress markers in rainbow trout (Oncorhynchus mykiss,Walbaum 1792)

(2015) E. Šišperová et al.   JOURNAL OF APPLIED ICHTHYOLOGY

Feed-borne exposure to deoxynivalenol leads to acute and chronic effects on liver enzymes and histology in carp

(2015) C. Pietsch et al.   World Mycotoxin Journal

Effects of Wheat Naturally Contaminated with Fusarium Mycotoxins on Growth Performance and Selected Health Indices of Red Tilapia (Oreochromis niloticus × O. mossambicus)

(2015) Siriporn Tola et al.   Toxins

Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed

(2015) Constanze Pietsch et al.   Mycotoxin Research

Diets containing corn naturally contaminated with deoxynivalenol reduces the susceptibility of rainbow trout (Oncorhynchus mykiss)to experimentalFlavobacterium psychrophiluminfection

(2014) Ian A Ryerse et al.   AQUACULTURE RESEARCH

Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update

(2014) Qing-Hua Wu et al.   ARCHIVES OF TOXICOLOGY

In vivo effects of deoxynivalenol (DON) on innate immune responses of carp (Cyprinus carpio L.)

(2014) Constanze Pietsch et al.   FOOD AND CHEMICAL TOXICOLOGY

Purified deoxynivalenol or feed restriction reduces mortality in rainbow trout, Oncorhynchus mykiss (Walbaum), with experimental bacterial coldwater disease but biologically relevant concentrations of deoxynivalenol do not impair the growth of Flavobacter

(2014) I A Ryerse et al.   JOURNAL OF FISH DISEASES

Potential for a Mycotoxin Deactivator to Improve Growth and Performance of Rainbow Trout fed High Levels of an Ethanol Industry Co-Product, Grain Distiller's Dried Yeast

(2014) Blake S. Hauptman et al.   NORTH AMERICAN JOURNAL OF AQUACULTURE

Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs

(2014) Veronika Nagl et al.   TOXICOLOGY LETTERS

Organ Damage and Hepatic Lipid Accumulation in Carp (Cyprinus carpio L.) after Feed-Borne Exposure to the Mycotoxin, Deoxynivalenol (DON)

(2014) Constanze Pietsch et al.   Toxins

The Effect of Mycotoxin Deoxynivalenol on Haematological and Biochemical Indicators and Histopathological Changes in Rainbow Trout (Oncorhynchus mykiss)

(2014) Iveta Matejova et al.   Biomed Research International

The efficacy of three mycotoxin adsorbents to alleviate aflatoxin B1-induced toxicity in Oreochromis niloticus

(2013) Khaled M. Selim et al.   AQUACULTURE INTERNATIONAL

Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review

(2013) Robert Klopfleisch   BMC Veterinary Research

Masked Mycotoxins Are Efficiently Hydrolyzed by Human Colonic Microbiota Releasing Their Aglycones

(2013) Andrea Dall’Erta et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparative study of β-glucan induced respiratory burst measured by nitroblue tetrazolium assay and real-time luminol-enhanced chemiluminescence assay in common carp (Cyprinus carpio L.)

(2013) N.I. Vera-Jimenez et al.   FISH & SHELLFISH IMMUNOLOGY

Enzyme-Assisted Synthesis and Structural Characterization of the 3-, 8-, and 15-Glucuronides of Deoxynivalenol

(2013) Silvio Uhlig et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolism, Distribution, and Excretion of Deoxynivalenol with Combined Techniques of Radiotracing, High-Performance Liquid Chromatography Ion Trap Time-of-Flight Mass Spectrometry, and Online Radiometric Detection

(2013) Dan Wan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mycotoxin occurrence in feed and feed raw materials worldwide: long-term analysis with special focus on Europe and Asia

(2013) Elisabeth Streit et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Peptide YY3–36 and 5-Hydroxytryptamine Mediate Emesis Induction by Trichothecene Deoxynivalenol (Vomitoxin)

(2013) Wenda Wu et al.   TOXICOLOGICAL SCIENCES

New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone

(2013) Benedikt Warth et al.   TOXICOLOGY LETTERS

The effect ofFusariummycotoxins deoxynivalenol, fumonisin, and moniliformin from contaminated moldy grains on aquaculture fish

(2013) Bruce B. Manning et al.   Toxin Reviews

Principles for Valid Histopathologic Scoring in Research

(2013) K. N. Gibson-Corley et al.   VETERINARY PATHOLOGY

Global occurrence of mycotoxins in the food and feed chain: facts and figures

(2013) G. Schatzmayr et al.   World Mycotoxin Journal

From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol

(2013) Marc Maresca   Toxins

The effect of NovaSil dietary supplementation on the growth and health performance of Nile tilapia (Oreochromis niloticus) fed aflatoxin-B1 contaminated feed

(2012) Katherine E. Zychowski et al.   AQUACULTURE

Investigation of the Hepatic Glucuronidation Pattern of the Fusarium Mycotoxin Deoxynivalenol in Various Species

(2012) Ronald Maul et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Development and validation of an LC-MS/MS method for the simultaneous determination of deoxynivalenol, zearalenone, T-2-toxin and some masked metabolites in different cereals and cereal-derived food

(2012) M. De Boevre et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Survey of deoxynivalenol and its conjugates deoxynivalenol-3-glucoside and 3-acetyl-deoxynivalenol in 374 beer samples

(2012) Elisabeth Varga et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Zebrafish (Danio rerio) as a model for investigating dietary toxic effects of deoxynivalenol contamination in aquaculture feeds

(2012) Monica Sanden et al.   FOOD AND CHEMICAL TOXICOLOGY

Toxicokinetic study and absolute oral bioavailability of deoxynivalenol, T-2 toxin and zearalenone in broiler chickens

(2012) Ann Osselaere et al.   FOOD AND CHEMICAL TOXICOLOGY

Masked mycotoxins: A review

(2012) Franz Berthiller et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds

(2012) W. A. Awad et al.   POULTRY SCIENCE

Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins

(2012) Benedikt Warth et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Anorexia Induction by the Trichothecene Deoxynivalenol (Vomitoxin) Is Mediated by the Release of the Gut Satiety Hormone Peptide YY

(2012) Brenna M. Flannery et al.   TOXICOLOGICAL SCIENCES

Assessment of human deoxynivalenol exposure using an LC–MS/MS based biomarker method

(2012) Benedikt Warth et al.   TOXICOLOGY LETTERS

Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats

(2012) Veronika Nagl et al.   TOXICOLOGY LETTERS

Synthesis of deoxynivalenol-3-ß-D-O-glucuronide for its use as biomarker for dietary deoxynivalenol exposure

(2012) P. Fruhmann et al.   World Mycotoxin Journal

Current Situation of Mycotoxin Contamination and Co-occurrence in Animal Feed—Focus on Europe

(2012) Elisabeth Streit et al.   Toxins

Direct quantification of deoxynivalenol glucuronide in human urine as biomarker of exposure to the Fusarium mycotoxin deoxynivalenol

(2011) Benedikt Warth et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets

(2011) Ana-Paula F. L. Bracarense et al.   BRITISH JOURNAL OF NUTRITION

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Individual and combined effects of subclinical doses of deoxynivalenol and fumonisins in piglets

(2011) Bertrand Grenier et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Central Inflammation and Sickness-Like Behavior Induced by the Food Contaminant Deoxynivalenol: A PGE2-Independent Mechanism

(2011) Clémence Girardet et al.   TOXICOLOGICAL SCIENCES

Frequent biphasic cellular responses of permanent fish cell cultures to deoxynivalenol (DON)

(2011) Constanze Pietsch et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hydrolytic fate of deoxynivalenol-3-glucoside during digestion

(2011) Franz Berthiller et al.   TOXICOLOGY LETTERS

Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells

(2011) Diana Dinu et al.   TOXICON

Survey of deoxynivalenol and deoxynivalenol-3-glucoside in cereal-based products by liquid chromatography electrospray ionization tandem mass spectrometry

(2011) A. Desmarchelier et al.   World Mycotoxin Journal

Mycotoxin co-contamination of food and feed: meta-analysis of publications describing toxicological interactions

(2011) B. Grenier et al.   World Mycotoxin Journal

Determination of optimal conditions for hydrolysis of conjugated deoxynivalenol in corn and wheat with trifluoromethanesulfonic acid

(2010) S.T. Tran et al.   ANIMAL FEED SCIENCE AND TECHNOLOGY

Rainbow trout (Oncorhynchus mykiss) is extremely sensitive to the feed-borne Fusarium mycotoxin deoxynivalenol (DON)

(2010) Jamie M. Hooft et al.   AQUACULTURE

Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance

(2010) James J. Pestka   ARCHIVES OF TOXICOLOGY

Morphologic Changes in the Intestine of Broiler Breeder Pullets Fed Diets Naturally Contaminated with Fusarium Mycotoxins With or Without Coccidial Challenge

(2010) G. N. Girgis et al.   AVIAN DISEASES

Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: Prevention of NF-κB nuclear localization and down regulation of NF-κB and Cyclo-Oxygenase – 2 expression

(2010) Rajashree Krishnaswamy et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Individual and Combined Effects of Deoxynivalenol and Aflatoxin B1 on Primary Hepatocytes of Cyprinus Carpio

(2010) Cheng-Hua He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deoxynivalenol Impairs Porcine Intestinal Barrier Function and Decreases the Protein Expression of Claudin-4 through a Mitogen-Activated Protein Kinase-Dependent Mechanism

(2010) Philippe Pinton et al.   JOURNAL OF NUTRITION

Hematopoietic Cell Kinase Associates with the 40S Ribosomal Subunit and Mediates the Ribotoxic Stress Response to Deoxynivalenol in Mononuclear Phagocytes

(2010) Heekyong Bae et al.   TOXICOLOGICAL SCIENCES

Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2

(2010) Anne-Kathrin Diesing et al.   TOXICOLOGY LETTERS

Deoxynivalenol-Induced Proinflammatory Gene Expression: Mechanisms and Pathological Sequelae

(2010) James J. Pestka   Toxins

Formation, determination and significance of masked and other conjugated mycotoxins

(2009) Franz Berthiller et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Transformation of trichothecene mycotoxins by microorganisms from fish digesta

(2009) Shu Guan et al.   AQUACULTURE

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Occurrence of deoxynivalenol and its 3-β-D-glucoside in wheat and maize

(2009) F. Berthiller et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Effectiveness of mycotoxin sequestration activity of micronized wheat fibres on distribution of ochratoxin A in plasma, liver and kidney of piglets fed a naturally contaminated diet

(2009) N. Aoudia et al.   FOOD AND CHEMICAL TOXICOLOGY

Occurrence of Deoxynivalenol and Its Major Conjugate, Deoxynivalenol-3-Glucoside, in Beer and Some Brewing Intermediates

(2009) Marta Kostelanska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of GRP78/BiP Degradation and ER Stress in Deoxynivalenol-Induced Interleukin-6 Upregulation in the Macrophage

(2009) Yuhui Shi et al.   TOXICOLOGICAL SCIENCES

Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells

(2009) Fatma Bensassi et al.   TOXICOLOGY

HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol

(2009) Hye Jin Choi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression

(2009) Philippe Pinton et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol: Histopathological analysis

(2009) Martine Kolf-Clauw et al.   TOXICOLOGY IN VITRO

Effects of aFusariumtoxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the13C-methacetin breath test

(2008) Sven Dänicke et al.   ARCHIVES OF ANIMAL NUTRITION

Mechanisms of deoxynivalenol-induced gene expression and apoptosis

(2008) J.J. Pestka   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Dietary Sphingomyelin Alleviates Experimental Inflammatory Bowel Disease in Mice

(2008) Furuya et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol

(2008) Saura C. Sahu et al.   JOURNAL OF APPLIED TOXICOLOGY

Effects of Feeding Blends of Grains Naturally Contaminated with Fusarium Mycotoxins on Small Intestinal Morphology of Turkeys

(2008) C. K. Girish et al.   POULTRY SCIENCE

Deoxynivalenol Induces p38 Interaction with the Ribosome in Monocytes and Macrophages

(2008) Hee Kyong Bae et al.   TOXICOLOGICAL SCIENCES

Double-Stranded RNA–Activated Protein Kinase Mediates Induction of Interleukin-8 Expression by Deoxynivalenol, Shiga Toxin 1, and Ricin in Monocytes

(2008) Jennifer S. Gray et al.   TOXICOLOGICAL SCIENCES

Comparative Induction of 28S Ribosomal RNA Cleavage by Ricin and the Trichothecenes Deoxynivalenol and T-2 Toxin in the Macrophage

(2008) Maoxiang Li et al.   TOXICOLOGICAL SCIENCES

The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) and zearalenone (ZON) on the spleen and liver of sow and fetus from day 35 to 70 of gestation

(2008) U. Tiemann et al.   TOXICOLOGY LETTERS

Microbial transformation of trichothecene mycotoxins

(2008) T. Zhou et al.   World Mycotoxin Journal

Distribution of ochratoxin A in plasma and tissues of rats fed a naturally contaminated diet amended with micronized wheat fibres: Effectiveness of mycotoxin sequestering activity

(2007) N. Aoudia et al.   FOOD AND CHEMICAL TOXICOLOGY

Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells

(2007) Hyun Yang et al.   TOXICOLOGY

Changes in the spleen and liver of pregnant sows and full-term piglets after feeding diets naturally contaminated with deoxynivalenol and zearalenone

(2007) U. Tiemann et al.   VETERINARY JOURNAL