The importance of increasing population diversity in genetic studies of type 2 diabetes and related glycaemic traits

The trans-ancestral genomic architecture of glycemic traits

(2021) Ji Chen et al.   NATURE GENETICS

The GWAS Diversity Monitor tracks diversity by disease in real time

(2020) Melinda C. Mills et al.   NATURE GENETICS

Identification of type 2 diabetes loci in 433,540 East Asian individuals

(2020) Cassandra N. Spracklen et al.   NATURE

Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals

(2020) Aaron Leong et al.   BMJ Open Diabetes Research & Care

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

(2020) Marijana Vujkovic et al.   NATURE GENETICS

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

(2020) Kazuyoshi Ishigaki et al.   NATURE GENETICS

Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India

(2020) James W. Harrison et al.   Scientific Reports

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations

(2020) Alicia R. Martin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Leveraging genetic ancestry to study health disparities

(2020) Ken Batai et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

(2020) Satoshi Koyama et al.   NATURE GENETICS

The Brazilian Initiative on Precision Medicine (BIPMed): fostering genomic data-sharing of underrepresented populations

(2020) Cristiane S. Rocha et al.   npj Genomic Medicine

The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland

(2020) Maria Overvad et al.   Scientific Reports

Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis

(2019) Seth A. Sharp et al.   DIABETES CARE

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

The Emergence of Genomic Research in Africa and New Frameworks for Equity in Biomedical Research

(2019) Amy R. Bentley et al.   ETHNICITY & DISEASE

Polygenic Risk Scores That Predict Common Diseases Using Millions of Single Nucleotide Polymorphisms: Is More, Better?

(2019) A. Cecile J.W. Janssens et al.   CLINICAL CHEMISTRY

The Genetic Basis of Metabolic Disease

(2019) Inês Barroso et al.   CELL

Genomic Research Through an Indigenous Lens: Understanding the Expectations

(2019) Nanibaa’ A. Garrison et al.   Annual Review of Genomics and Human Genetics

Clinical relevance of genome‐wide polygenic score may be less than claimed

(2019) David Curtis   ANNALS OF HUMAN GENETICS

Genome-wide association study of type 2 diabetes in Africa

(2019) Ji Chen et al.   DIABETOLOGIA

Polygenic prediction via Bayesian regression and continuous shrinkage priors

(2019) Tian Ge et al.   Nature Communications

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

(2019) Mashaal Sohail et al.   eLife

Reduced signal for polygenic adaptation of height in UK Biobank

(2019) Jeremy J Berg et al.   eLife

A Genome-Wide Association Study Identifies Blood Disorder–Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos

(2019) Jee-Young Moon et al.   DIABETES CARE

Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of

(2019) H. Yaghootkar et al.   DIABETIC MEDICINE

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

(2019) Adebowale A. Adeyemo et al.   Nature Communications

Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine

(2019) Miriam S Udler et al.   ENDOCRINE REVIEWS

Genome-wide association study for proliferative diabetic retinopathy in Africans

(2019) Chang Liu et al.   npj Genomic Medicine

Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program

(2019) Chloé Sarnowski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa

(2019) Deepti Gurdasani et al.   CELL

A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes

(2018) Matthew B. Johnson et al.   DIABETOLOGIA

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Favism and Glucose-6-Phosphate Dehydrogenase Deficiency

(2018) Lucio Luzzatto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling

(2018) Daniel J. Perry et al.   Scientific Reports

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Genetic risks and clinical rewards

(2018) Andrew J. Schork et al.   NATURE GENETICS

GWAS to the people

(2018)   NATURE MEDICINE

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

(2018) Miriam S. Udler et al.   PLOS MEDICINE

Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics

(2018) Shakuntala Baichoo et al.   BMC BIOINFORMATICS

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Introducing “Genomics and Precision Health”

(2017) W. Gregory Feero   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of Sickle Cell Trait With Hemoglobin A1c in African Americans

(2017) Mary E. Lacy et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

South Africa’s San people issue ethics code to scientists

(2017) Ewen Callaway   NATURE

Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens

(2017) Cindy S. Chu et al.   PLOS MEDICINE

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

(2017) Rahul S. Desikan et al.   PLOS MEDICINE

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

(2017) Eleanor Wheeler et al.   PLOS MEDICINE

Equity in international health research collaborations in Africa: Perceptions and expectations of African researchers

(2017) Nchangwi Syntia Munung et al.   PLoS One

Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes

(2016) Kashyap A. Patel et al.   DIABETES

Toward Precision Medicine: TBC1D4 Disruption Is Common Among the Inuit and Leads to Underdiagnosis of Type 2 Diabetes

(2016) Despoina Manousaki et al.   DIABETES CARE

Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities

(2016) Caren E. Smith et al.   HEALTH AFFAIRS

Genomics is failing on diversity

(2016) Alice B. Popejoy et al.   NATURE

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Developing and evaluating polygenic risk prediction models for stratified disease prevention

(2016) Nilanjan Chatterjee et al.   NATURE REVIEWS GENETICS

Partnerships, Not Parachutists, for Zika Research

(2016) David L. Heymann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

(2016) Jianxin Shi et al.   PLoS Genetics

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of Genome Wide Association Study Associated Type 2 Diabetes Susceptibility Loci in Sub Saharan Africans

(2015) Adebowale A. Adeyemo et al.   Frontiers in Genetics

PRSice: Polygenic Risk Score software

(2014) Jack Euesden et al.   BIOINFORMATICS

Using population isolates in genetic association studies

(2014) K. Hatzikotoulas et al.   Briefings in Functional Genomics

Twenty years post-NIH Revitalization Act: Enhancing minority participation in clinical trials (EMPaCT): Laying the groundwork for improving minority clinical trial accrual

(2014) Moon S. Chen et al.   CANCER

Prevalence of Vascular Complications Among Patients With Glucokinase Mutations and Prolonged, Mild Hyperglycemia

(2014) Anna M. Steele et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of a Low-Frequency Variant inHNF1AWith Type 2 Diabetes in a Latino Population

(2014) Karol Estrada et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

(2014) Ida Moltke et al.   NATURE

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Enabling the genomic revolution in Africa

(2014) et al.   SCIENCE

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

(2014) Maggie C. Y. Ng et al.   PLoS Genetics

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

(2013)   NATURE

Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies

(2013) Nilanjan Chatterjee et al.   NATURE GENETICS

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

(2012) Robert A Scott et al.   NATURE GENETICS

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Using Lifetime Risk Estimates in Personal Genomic Profiles: Estimation of Uncertainty

(2009) Quanhe Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Next generation disparities in human genomics: concerns and remedies

(2009) Anna C. Need et al.   TRENDS IN GENETICS

Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk

(2008) H. Lango et al.   DIABETES

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

(2008) James B. Meigs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE