Article
Ophthalmology
Xiaoxiao Yan, Haibo Jia, Junbo Zhao
Summary: This study investigated the impact of long non-coding RNA (lncRNA) MEG3 on the biological features of retinoblastoma (RB) cells. The results showed that overexpressing MEG3 significantly reduced cell proliferation and migration and increased apoptosis in RB cells. Additionally, overexpressing MEG3 inhibited the activation of the PI3K/Akt/mTOR signaling pathway. This study suggests that MEG3 could be a potential new therapeutic agent and target for RB therapy.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yuwei Fang, Kangpei Shi, Haining Lu, Lin Lu, Bo Qiu
Summary: Mingmu Xiaomeng tablets can protect the diabetic retina by inhibiting the PI3K/Akt/mTOR signaling pathway, promoting autophagy, and improving retinal function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Rui Lu, Zhiyi He, Weikai Zhang, Yingguang Wang, Peng Cheng, Zhengtao Lv, Xuefeng Yuan, Fengjing Guo, Hongbo You, An-min Chen, Weihua Hu
Summary: This study explored the potential chondroprotective effect of Oroxin B (OB) in osteoarthritis (OA) and elucidated its mechanism. The results showed that OB protected chondrocytes by inhibiting inflammation, suppressing the PI3K/AKT/mTOR signaling pathway, and enhancing autophagy. These findings suggest that OB may be a promising agent for the treatment of OA, providing a new direction for OA therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Yue Yu, Hong Chen, Jiantao Zhang, Tianwen Ma, Liangyu Lv, Lina Jia, Hongri Ruan, Li Gao
Summary: Research has shown that Oleanolic acid (OLA) has the potential to improve symptoms of osteoarthritis by activating autophagy and inhibiting inflammation and cartilage degeneration.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Oncology
Wenliang Chen, Zhuo Li, Junfang Duan, Yingtao Liu, Changzhong Fang, Zihao Bai
Summary: This study found that the expression of SNHG6 is increased in GC patients and it can promote the development of GC by activating the PI3K/AKT/mTOR signaling pathway and suppressing cell autophagy. The results provide important reference for the diagnosis and treatment of GC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Xiang Li, Kuangqi Chen, Zixi Wang, Jiayuan Li, Xiawei Wang, Chen Xie, Jianping Tong, Ye Shen
Summary: Corneal diseases affect millions of people worldwide and current treatments have limitations. Activation of the mTOR signaling pathway is involved in the pathogenesis of various corneal diseases, and inhibition of mTOR with rapamycin has shown promising outcomes, indicating the potential of mTOR as a therapeutic target.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Veterinary Sciences
Gianmarco Ferrara, Consiglia Longobardi, Sara Damiano, Roberto Ciarcia, Ugo Pagnini, Serena Montagnaro
Summary: This study aims to investigate the involvement of the PI3K/Akt/mTOR pathway during FeHV-1 infection. The results suggest that FeHV-1 may interact independently with different autophagic signaling pathways. Additionally, early phosphorylation of Akt after infection may be related to viral entry.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Shuwei Ning, Siqi Zhang, Zhikun Guo
Summary: This study aimed to investigate the role and mechanism of microRNA (miR)-494 in cardiomyocyte apoptosis and autophagy induced by high glucose (HG). The results showed that miR-494 could regulate cell apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway, participating in the regulation of cardiomyocyte damage after HG.
Article
Pharmacology & Pharmacy
Xiangjin Zheng, Wan Li, Huanli Xu, Jinyi Liu, Liwen Ren, Yihui Yang, Sha Li, Jinhua Wang, Tengfei Ji, Guanhua Du
Summary: GBM is a deadly form of advanced glioma with no effective treatment currently available. Sinomenine derivative SW33 shows promising antitumor activity against GBM by regulating PI3K/AKT and AMPK signaling pathways, and inducing autophagy as well. SW33 appears to be a safe and effective drug for GBM treatment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell Biology
Kexiang Zhang, Song Wu, Hongwei Wu, Li Liu, Jiahui Zhou
Summary: The study demonstrated that activation of Notch1 by doxycycline effectively suppressed cell proliferation and induced S phase arrest in osteosarcoma cells, while also triggering apoptosis and autophagy. Notch1 activation inhibited the PI3K/Akt/mTOR signaling pathway to induce apoptosis and autophagy.
Review
Pharmacology & Pharmacy
Zining Li, Jialiang Gao, Di Sun, Qian Jiao, Jing Ma, Weilu Cui, Yuqing Lou, Fan Xu, Shanshan Li, Haixia Li
Summary: Research suggests that MEG3 is involved in the occurrence and development of cardiovascular diseases, and has great potential in the prevention and treatment of these diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ke Chen, Bo Yu, Jie Liao
Summary: This study showed that lncRNA SOX2OT alleviates the pathogenesis of DN by regulating Akt/mTOR-mediated autophagy, suppressing the proliferation and fibrosis of mesangial cells.
MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Vivek Makwana, Santosh Rudrawar, Shailendra Anoopkumar-Dukie
Summary: Hexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways play crucial roles in the proliferation and survival of prostate cancer cells by increasing androgen receptor expression and protein levels. Inhibition of a single pathway is insufficient to halt disease progression, suggesting that targeting multiple pathways at common junctions may be beneficial for effective management of prostate cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Pharmacology & Pharmacy
Bishwanath Acharya, Wanna Chaijaroenkul, Kesara Na-Bangchang
Summary: Atractylodin inhibits proliferation and induces autophagy in cholangiocarcinoma cells by regulating the PI3K/AKT/mTOR and p38MAPK signaling pathways.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.