LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy

Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression

(2019) Xiaoxu Ge et al.   Aging-US

LncRNA SOX2OT alleviates the high glucose-induced podocytes injury through autophagy induction by the miR-9/SIRT1 axis

(2019) Yan Zhang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

LncRNA-NR_033515 promotes proliferation, fibrogenesis and epithelial-to-mesenchymal transition by targeting miR-743b-5p in diabetic nephropathy

(2018) Junjie Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Values and Limitations of Targeting lncRNAs in Diabetic Nephropathy

(2018) Jianyin Long et al.   DIABETES

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

(2018) Hyejin Lim et al.   Nature Communications

Reduced Autophagy by a microRNA-mediated Signaling Cascade in Diabetes-induced Renal Glomerular Hypertrophy

(2018) Supriya Deshpande et al.   Scientific Reports

Long Non-Coding RNA CYP4B1-PS1-001 Inhibits Proliferation and Fibrosis in Diabetic Nephropathy by Interacting with Nucleolin

(2018) Suyu Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

lncRNA ZEB1-AS1 Was Suppressed by p53 for Renal Fibrosis in Diabetic Nephropathy

(2018) Juan Wang et al.   Molecular Therapy-Nucleic Acids

Long noncoding RNA NEAT1 accelerates the proliferation and fibrosis in diabetic nephropathy through activating Akt/mTOR signaling pathway

(2018) Shan Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long noncoding RNA Gm6135 functions as a competitive endogenous RNA to regulate toll-like receptor 4 expression by sponging miR-203-3p in diabetic nephropathy

(2018) Ting-Ting Ji et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LncRNA NEAT1 promotes extracellular matrix accumulation and epithelial‐to‐mesenchymal transition by targeting miR‐27b‐3p and ZEB1 in diabetic nephropathy

(2018) Xiaowei Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway

(2017) Fei Han et al.   International Journal of Biological Sciences

LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with β-catenin

(2017) Mengsi Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells

(2017) Sang-Hun Kim et al.   Pharmacological Reports

Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury

(2016) Chao-Peng Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway

(2016) Yuxia Sui et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy

(2016) Min Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation

(2016) Daniel Fantus et al.   Nature Reviews Nephrology

Long non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis

(2015) Alireza Shahryari et al.   Frontiers in Genetics

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Losartan Affects Glomerular AKT and mTOR Phosphorylation in an Experimental Model of Type 1 Diabetic Nephropathy

(2013) Vasiliki Mavroeidi et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease

(2009) W. Lieberthal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY