Creation of an Engineered Amide Synthetase Biocatalyst by the Rational Separation of a Two‐Step Nitrile Synthetase

Discovery, characterization and engineering of ligases for amide synthesis

(2021) Michael Winn et al.   NATURE

Harnessing and engineering amide bond forming ligases for the synthesis of amides

(2020) Michael Winn et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biocatalysis in drug discovery and development

(2020) Anna Fryszkowska et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production

(2019) Albert Isidro-Llobet et al.   JOURNAL OF ORGANIC CHEMISTRY

Versatility of Candida antarctica lipase in the amide bond formation applied in organic synthesis and biotechnological processes

(2019) Rafaely N. Lima et al.   Molecular Catalysis

Using enzyme cascades in biocatalysis: Highlight on transaminases and carboxylic acid reductases

(2019) Rhys Cutlan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Carboxylic acid reductase: Structure and mechanism

(2019) Deepankar Gahloth et al.   JOURNAL OF BIOTECHNOLOGY

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Carboxylic acid reductase enzymes (CARs)

(2018) Margit Winkler   CURRENT OPINION IN CHEMICAL BIOLOGY

Extending the application of biocatalysis to meet the challenges of drug development

(2018) Paul N. Devine et al.   Nature Reviews Chemistry

A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate

(2015) Micah T. Nelp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Nitrile-Forming Enzyme 7-Cyano-7-Deazaguanine Synthase fromGeobacillus kaustophilus: A Reverse Nitrilase?

(2015) Margit Winkler et al.   CHEMBIOCHEM

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Alpha Subunit of Nitrile Hydratase Is Sufficient for Catalytic Activity and Post-Translational Modification

(2014) Micah T. Nelp et al.   BIOCHEMISTRY

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

Adenylate-forming enzymes

(2009) Stefan Schmelz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural and Functional Studies of the Biotin Protein Ligase from Aquifex aeolicus Reveal a Critical Role for a Conserved Residue in Target Specificity

(2009) Cecile M. Tron et al.   JOURNAL OF MOLECULAR BIOLOGY

Deciphering Deazapurine Biosynthesis: Pathway for Pyrrolopyrimidine Nucleosides Toyocamycin and Sangivamycin

(2008) Reid M. McCarty et al.   CHEMISTRY & BIOLOGY

Crystal structure of QueC from Bacillus subtilis: An enzyme involved in preQ1 biosynthesis

(2008) Nenad Cicmil et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS