Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism

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Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9

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ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

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Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

(2019) Julien N. Bianco et al.   Nature Communications

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(2019) Mahmoud Ghandi et al.   NATURE

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(2018) Yun Zhang et al.   Frontiers of Medicine

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(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion

(2018) Alexandra C. Title et al.   Nature Communications

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SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin

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Aberrant TIMELESS expression is associated with poor clinical survival and lymph node metastasis in early-stage cervical carcinoma

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A Timeless Link Between Circadian Patterns and Disease

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Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

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TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

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TIMELESSis overexpressed in lung cancer and its expression correlates with poor patient survival

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Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation

(2012) Gina Mendez et al.   IUBMB LIFE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

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Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion

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(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

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