Lineage factors and differentiation states in lung cancer progression

Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma

(2015) Kathleen M. Capaccione et al.   Oncotarget

GATA6 Promotes Colon Cancer Cell Invasion by Regulating Urokinase Plasminogen Activator Gene Expression

(2015) Narasimhaswamy S Belaguli et al.   NEOPLASIA

Epigenetic Silencing of HOPX Promotes Cancer Progression in Colorectal Cancer

(2015) Hiroshi Katoh et al.   NEOPLASIA

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

(2014) Annie M. Tremblay et al.   CANCER CELL

Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression

(2014) Chunxiao Xu et al.   CANCER CELL

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

(2014) Verline Justilien et al.   CANCER CELL

Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

(2014) David G. McFadden et al.   CELL

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

(2014) Edmond Chipumuro et al.   CELL

Transforming growth factor-beta signaling network regulates plasticity and lineage commitment of lung cancer cells

(2014) I Ischenko et al.   CELL DEATH AND DIFFERENTIATION

The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2

(2014) Xia Xu et al.   GENES & DEVELOPMENT

Diminished WNT ->  -catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors

(2014) J. Juan et al.   GENES & DEVELOPMENT

SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas

(2014) Hideo Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer

(2014) Yuan Chen et al.   JOURNAL OF PATHOLOGY

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

p63+Krt5+ distal airway stem cells are essential for lung regeneration

(2014) Wei Zuo et al.   NATURE

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

(2014) Andrew E. Vaughan et al.   NATURE

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

(2014) Francisco J. Sánchez-Rivera et al.   NATURE

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

(2014) Barbara Treutlein et al.   NATURE

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

Multiple cells-of-origin of mutant K-Ras–induced mouse lung adenocarcinoma

(2014) Kate D. Sutherland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2

(2014) Felix R Jimenez et al.   RESPIRATORY RESEARCH

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

(2014) D. J. Konieczkowski et al.   Cancer Discovery

Sox2 Cooperates with Lkb1 Loss in a Mouse Model of Squamous Cell Lung Cancer

(2014) Anandaroop Mukhopadhyay et al.   Cell Reports

Directed Phenotype Switching as an Effective Antimelanoma Strategy

(2013) Magalí Sáez-Ayala et al.   CANCER CELL

The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas

(2013) Zuoxiang Xiao et al.   CANCER CELL

Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma

(2013) You-Soub Lee et al.   CANCER CELL

Hopping between Differentiation States in Lung Adenocarcinoma

(2013) Hideo Watanabe et al.   CANCER CELL

NKX2-1/TTF-1: An Enigmatic Oncogene that Functions as a Double-Edged Sword for Cancer Cell Survival and Progression

(2013) Tomoya Yamaguchi et al.   CANCER CELL

Control of Alveolar Differentiation by the Lineage Transcription Factors GATA6 and HOPX Inhibits Lung Adenocarcinoma Metastasis

(2013) William K.C. Cheung et al.   CANCER CELL

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non-Small Cell Lung Cancer

(2013) T. Shimamura et al.   CLINICAL CANCER RESEARCH

Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target

(2013) H. Watanabe et al.   GENES & DEVELOPMENT

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

(2013) L. Soucek et al.   GENES & DEVELOPMENT

Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer

(2013) Reika Iwakawa et al.   GENES CHROMOSOMES & CANCER

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas

(2013) Olivier Govaere et al.   GUT

Epigenetic downregulation of RUNX3 by DNA methylation induces docetaxel chemoresistance in human lung adenocarcinoma cells by activation of the AKT pathway

(2013) Yun Zheng et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

New Pathologic Classification of Lung Cancer: Relevance for Clinical Practice and Clinical Trials

(2013) William D. Travis et al.   JOURNAL OF CLINICAL ONCOLOGY

Wnt Signaling Pathway in Non-Small Cell Lung Cancer

(2013) D. J. Stewart   JNCI-Journal of the National Cancer Institute

Transformation to “high grade” neuroendocrine carcinoma as an acquired drug resistance mechanism in EGFR-mutant lung adenocarcinoma

(2013) S. Popat et al.   LUNG CANCER

Transformation to small-cell lung cancer following treatment with EGFR tyrosine kinase inhibitors in a patient with lung adenocarcinoma

(2013) Satoshi Watanabe et al.   LUNG CANCER

Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma

(2013) Eric L. Snyder et al.   MOLECULAR CELL

Tracing the cellular origin of cancer

(2013) Cédric Blanpain   NATURE CELL BIOLOGY

CCAAT/Enhancer-Binding Protein-α Suppresses Lung Tumor Development in Mice through the p38α MAP Kinase Pathway

(2013) Atsuyasu Sato et al.   PLoS One

Lung epithelial branching program antagonizes alveolar differentiation

(2013) D. R. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

(2013) B. E. Rockich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma

(2013) S. Mainardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas

(2013) Il-Jin Kim et al.   Nature Communications

MAX Inactivation in Small Cell Lung Cancer Disrupts MYC-SWI/SNF Programs and Is Synthetic Lethal with BRG1

(2013) O. A. Romero et al.   Cancer Discovery

CCAAT/Enhancer Binding Protein–α Regulates the Protease/Antiprotease Balance Required for Bronchiolar Epithelium Regeneration

(2012) Atsuyasu Sato et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis

(2012) Mina Waraya et al.   BMC CANCER

NKX2-1/TITF1/TTF-1-Induced ROR1 Is Required to Sustain EGFR Survival Signaling in Lung Adenocarcinoma

(2012) Tomoya Yamaguchi et al.   CANCER CELL

EMT and MET in Metastasis: Where Are the Cancer Stem Cells?

(2012) Thomas Brabletz   CANCER CELL

Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models

(2012) Ryan B. Corcoran et al.   CANCER CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear β-catenin in cerebral metastasis of lung adenocarcinomas

(2012) A. Bleckmann et al.   CLINICAL & EXPERIMENTAL METASTASIS

An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

(2012) L. A. Byers et al.   CLINICAL CANCER RESEARCH

KrasG12D and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung

(2012) Yutaka Maeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical significance of SOX9 in human non-small cell lung cancer progression and overall patient survival

(2012) Chun-Hui Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing

(2012) Daniela S. Basseres et al.   LUNG CANCER

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

(2012) Zhenfeng Zhang et al.   NATURE GENETICS

Alveolar Type II Cells Possess the Capability of Initiating Lung Tumor Development

(2012) Chuwen Lin et al.   PLoS One

Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma

(2012) L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis

(2012) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma

(2012) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

(2012) W. W. Lockwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The a“MAZE”ing World of Lung-Specific Transgenic Mice

(2011) Emma L. Rawlins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

(2011) Joaquim Calbo et al.   CANCER CELL

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

Interaction between MYC and MCL1 in the Genesis and Outcome of Non-Small-Cell Lung Cancer

(2011) T. D. Allen et al.   CANCER RESEARCH

Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma

(2011) T. D. Allen et al.   CANCER RESEARCH

Characterization of the cell of origin for small cell lung cancer

(2011) Kwon-Sik Park et al.   CELL CYCLE

Abnormalities of the TITF-1 Lineage-Specific Oncogene in NSCLC: Implications in Lung Cancer Pathogenesis and Prognosis

(2011) X. Tang et al.   CLINICAL CANCER RESEARCH

Runx3 is a crucial regulator of alveolar differentiation and lung tumorigenesis in mice

(2011) Jong-Min Lee et al.   DIFFERENTIATION

MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis

(2011) Yasuyuki Hosono et al.   EMBO JOURNAL

Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium

(2011) Eugenia C. Pacheco-Pinedo et al.   JOURNAL OF CLINICAL INVESTIGATION

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice

(2011) Yanan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Small-cell lung cancer

(2011) Jan P van Meerbeeck et al.   LANCET

Adenosquamous lung carcinomas: A histologic subtype with poor prognosis

(2011) Pier Luigi Filosso et al.   LUNG CANCER

Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma

(2011) Hidetaka Uramoto et al.   LUNG CANCER

Suppression of lung adenocarcinoma progression by Nkx2-1

(2011) Monte M. Winslow et al.   NATURE

GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1

(2011) Yi Zhong et al.   PLoS One

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

(2011) L. V. Sequist et al.   Science Translational Medicine

Survival Comparison of Adenosquamous, Squamous Cell, and Adenocarcinoma of the Lung After Lobectomy

(2010) David T. Cooke et al.   ANNALS OF THORACIC SURGERY

FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers

(2010) Yunneng Tang et al.   CELL RESEARCH

Primary Tumor Genotype Is an Important Determinant in Identification of Lung Cancer Propagating Cells

(2010) Stephen J. Curtis et al.   Cell Stem Cell

Upregulation of SOX9 in Lung Adenocarcinoma and Its Involvement in the Regulation of Cell Growth and Tumorigenicity

(2010) S. S. Jiang et al.   CLINICAL CANCER RESEARCH

Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells

(2010) B. Campos et al.   CLINICAL CANCER RESEARCH

MYC Amplification as a Prognostic Marker of Early-Stage Lung Adenocarcinoma Identified by Whole Genome Copy Number Analysis

(2010) Reika Iwakawa et al.   CLINICAL CANCER RESEARCH

Small-Cell Carcinoma With an Epidermal Growth Factor Receptor Mutation in a Never-Smoker With Gefitinib-Responsive Adenocarcinoma of the Lung

(2010) Naheed Alam et al.   Clinical Lung Cancer

Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development

(2010) Edward E. Morrisey et al.   DEVELOPMENTAL CELL

Cell of origin of lung cancer

(2010) Kate D. Sutherland et al.   Molecular Oncology

Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer

(2010) K-S Lee et al.   ONCOGENE

Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer

(2010) A Ooki et al.   ONCOGENE

SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas

(2010) Thomas Hussenet et al.   PLoS One

Evidence That SOX2 Overexpression Is Oncogenic in the Lung

(2010) Yun Lu et al.   PLoS One

Runt-Related Transcription Factor RUNX3 Is a Target of MDM2-Mediated Ubiquitination

(2009) X.-Z. Chi et al.   CANCER RESEARCH

Thyroid Transcription Factor-1 Inhibits Transforming Growth Factor- -Mediated Epithelial-to-Mesenchymal Transition in Lung Adenocarcinoma Cells

(2009) R.-A. Saito et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition and Cell Cooperativity in Metastasis

(2009) T. Tsuji et al.   CANCER RESEARCH

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

Multiple roles for Sox2 in the developing and adult mouse trachea

(2009) J. Que et al.   DEVELOPMENT

Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut

(2009) Ashley M. Goss et al.   DEVELOPMENTAL CELL

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

(2009) D. L. Gibbons et al.   GENES & DEVELOPMENT

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

(2009) Adam J Bass et al.   NATURE GENETICS

Myc Is a Metastasis Gene for Non-Small-Cell Lung Cancer

(2009) Ulf R. Rapp et al.   PLoS One

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

(2008) David J. Wong et al.   Cell Stem Cell

Systematic functional characterization of cis-regulatory motifs in human core promoters

(2008) S. Sinha et al.   GENOME RESEARCH

Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines

(2008) Pedro P. Medina et al.   HUMAN MUTATION

Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor

(2008) Shinichiro Yamaguchi et al.   INTERNATIONAL JOURNAL OF CANCER

CAATT/Enhancer-binding Proteins α and δ Interact with NKX2-1 to Synergistically Activate Mouse Secretoglobin 3A2 Gene Expression

(2008) Takeshi Tomita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancer of Zeste Homologue 2 (EZH2) Down-regulates RUNX3 by Increasing Histone H3 Methylation

(2008) Satoshi Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical significance of TTF-1 protein expression andTTF-1gene amplification in lung adenocarcinoma

(2008) Justine A. Barletta et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell Expansion

(2008) M. P. Quinlan et al.   MOLECULAR AND CELLULAR BIOLOGY

HOP/OB1/NECC1 Promoter DNA Is Frequently Hypermethylated and Involved in Tumorigenic Ability in Esophageal Squamous Cell Carcinoma

(2008) K. Yamashita et al.   MOLECULAR CANCER RESEARCH

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration

(2008) Yuzhen Zhang et al.   NATURE GENETICS

Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

(2008) K A Kwei et al.   ONCOGENE

Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas

(2008) Phuoc T. Tran et al.   PLoS One

Conditional Stabilization of β-Catenin Expands the Pool of Lung Stem Cells

(2008) Susan D. Reynolds et al.   STEM CELLS

Genomic Profiling Identifies GATA6 as a Candidate Oncogene Amplified in Pancreatobiliary Cancer

(2008) Kevin A. Kwei et al.   PLoS Genetics