标题
Celastrol in cancer therapy: Recent developments, challenges and prospects
作者
关键词
Celastrol, Anti-cancer activity, Pharmacokinetics, Toxicity, Translational potential
出版物
CANCER LETTERS
Volume 521, Issue -, Pages 252-267
出版商
Elsevier BV
发表日期
2021-09-09
DOI
10.1016/j.canlet.2021.08.030
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS‐mitochondrial fission‐mitophagy axis
- (2021) Ming Liu et al. Molecular Oncology
- Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells
- (2021) Andrey A. Parkhitko et al. PLoS Genetics
- Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines
- (2021) Yuanyuan Li et al. BMC GENOMICS
- Celastrol inhibit the proliferation, invasion and migration of human cervical HeLa cancer cells through down‐regulation of MMP‐2 and MMP‐9
- (2021) Jing Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Celastrol attenuates the inflammatory response by inhibiting IL‑1β expression in triple‑negative breast cancer cells
- (2021) Daeun You et al. ONCOLOGY REPORTS
- Celastrol Attenuates Lipid Accumulation and Stemness of Clear Cell Renal Cell Carcinoma via CAV-1/LOX-1 Pathway
- (2021) Chan-Juan Zhang et al. Frontiers in Pharmacology
- Celastrol and Triptolide Suppress Stemness in Triple Negative Breast Cancer: Notch as a Therapeutic Target for Stem Cells
- (2021) Prabhu Ramamoorthy et al. Biomedicines
- A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer
- (2021) Xi Liu et al. BIOCHEMICAL PHARMACOLOGY
- Discovery of novel celastrol-triazole derivatives with Hsp90-Cdc37 disruption to induce tumor cell apoptosis
- (2021) Na Li et al. BIOORGANIC CHEMISTRY
- Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1α pathway
- (2021) Fan-Fan Shang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Improved delivery system for celastrol-loaded magnetic Fe3O4/α-Fe2O3 heterogeneous nanorods: HIF-1α-related apoptotic effects on SMMC-7721 cell
- (2021) Ruijiang Liu et al. Materials Science & Engineering C-Materials for Biological Applications
- Organoids and Colorectal Cancer
- (2021) Antonio Barbáchano et al. Cancers
- Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles
- (2020) Zhanrong Li et al. DRUG DELIVERY
- Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review
- (2020) Mahshid Moballegh Nasery et al. MOLECULES
- Metabolomics Reveals that Cysteine Metabolism Plays a Role in Celastrol-Induced Mitochondrial Apoptosis in HL-60 and NB-4 Cells
- (2020) Minjian Chen et al. Scientific Reports
- Folic acid-modified celastrol nanoparticles: synthesis, characterization, anticancer activity in 2D and 3D breast cancer models
- (2020) Siukan Law et al. Artificial Cells Nanomedicine and Biotechnology
- The multifaceted role of reactive oxygen species in tumorigenesis
- (2020) Anuradha Kirtonia et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Preparation of high drug-loading celastrol nanosuspensions and their anti-breast cancer activities in vitro and in vivo
- (2020) Tiantian Huang et al. Scientific Reports
- Enhanced solubility, stability, permeation and anti-cancer efficacy of Celastrol-β-cyclodextrin inclusion complex
- (2020) Snehal K. Shukla et al. JOURNAL OF MOLECULAR LIQUIDS
- Targeting HER2 in Breast Cancer: Latest Developments on Treatment Sequencing and the Introduction of Biosimilars
- (2020) Megan E. Tesch et al. DRUGS
- Biotransformation of celastrol to a novel, well-soluble, low-toxic and anti-oxidative celastrol-29-O-β-glucoside by Bacillus glycosyltransferases
- (2020) Te-Sheng Chang et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Celastrol acts synergistically with afatinib to suppress non‐small cell lung cancer cell proliferation by inducing paraptosis
- (2020) Chun‐Hau Dai et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- (2020) Jinfeng Shi et al. Frontiers in Pharmacology
- A Combined Systemic Strategy for Overcoming Cisplatin Resistance in Head and Neck Cancer: From Target Identification to Drug Discovery
- (2020) Yin-Ju Chen et al. Cancers
- Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy
- (2020) Nasha Qiu et al. BIOMATERIALS
- Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication
- (2019) Chin-Yap Loh et al. Frontiers in Oncology
- Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
- (2019) Li-Na Xu et al. Frontiers in Oncology
- Role of Natural Products in Modulating Histone Deacetylases in Cancer
- (2019) Myriam Merarchi et al. MOLECULES
- CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii
- (2019) Chunhuan Jin et al. MOLECULES
- SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway
- (2019) Ziwen Chen et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Natural product-based nanoformulations for cancer therapy: Opportunities and challenges
- (2019) Dharambir Kashyap et al. SEMINARS IN CANCER BIOLOGY
- Integrated metabolomics and network toxicology to reveal molecular mechanism of celastrol induced cardiotoxicity
- (2019) Chuanxin Liu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Celastrol inhibits cancer metastasis by suppressing M2-like polarization of macrophages
- (2018) Yuening Yang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Synthesis and Biological Evaluation of a Series of Novel Celastrol Derivatives with Amino Acid Chain
- (2018) Chaohai Pang et al. CHEMISTRY & BIODIVERSITY
- Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy
- (2018) Zar Chi Soe et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport
- (2018) Zengfu Wang et al. PHARMACEUTICAL BIOLOGY
- Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention
- (2018) Devesh Tewari et al. PHARMACOLOGICAL RESEARCH
- Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review
- (2018) Gautam Sethi et al. Nutrients
- Chemopreventive activity of celastrol in drug–resistant human colon carcinoma cell cultures
- (2018) Helena Moreira et al. Oncotarget
- Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma
- (2018) Muthu K. Shanmugam et al. Frontiers in Pharmacology
- Why Chinese medicine is heading for clinics around the world
- (2018) David Cyranoski NATURE
- Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms
- (2016) Wei Chang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Synergism between NF-kappa B inhibitor, celastrol, and XIAP inhibitor, embelin, in an acute myeloid leukemia cell line, HL-60
- (2016) HosseinZarei Jaliani et al. Journal of Cancer Research and Therapeutics
- Natural Products as Sources of New Drugs from 1981 to 2014
- (2016) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Elucidation of the Intestinal Absorption Mechanism of Celastrol Using the Caco-2 Cell Transwell Model
- (2016) Hong Li et al. PLANTA MEDICA
- Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway
- (2016) Chakrabhavi Dhananjaya Mohan et al. PLoS One
- Investigation of the influence of glycyrrhizin on the pharmacokinetics of celastrol in rats using LC-MS and its potential mechanism
- (2016) Guangkui Yan et al. XENOBIOTICA
- Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells
- (2016) Xiaoling Zhang et al. Oncotarget
- Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives
- (2016) Pei Shi Ong et al. Frontiers in Pharmacology
- Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4
- (2015) Chunhuan Jin et al. XENOBIOTICA
- Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study
- (2015) H-Y Li et al. Cell Death & Disease
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel
- (2015) Jong Hyun Lee et al. Oncotarget
- Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
- (2015) Hyun-Woo Lee et al. BMB Reports
- Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts
- (2015) Wei Wei et al. Oncotarget
- Solid self-microemulsifying dispersible tablets of celastrol: Formulation development, charaterization and bioavailability evaluation
- (2014) Xiaole Qi et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Lack of Neuroprotective Effect of Celastrol Under Conditions of Proteasome Inhibition by Lactacystin in In Vitro and In Vivo Studies: Implications for Parkinson’s Disease
- (2014) Jolanta Konieczny et al. NEUROTOXICITY RESEARCH
- Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-κB activity
- (2013) Min Sha et al. Cancer Cell International
- Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
- (2013) Jong Hyun Lee et al. CANCER LETTERS
- Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma
- (2013) F. Li et al. Cancer Prevention Research
- Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer
- (2013) Zi Liu et al. CARCINOGENESIS
- Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity
- (2013) Min Sun et al. FITOTERAPIA
- Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo
- (2013) Hong-Lei Jiang et al. MOLECULAR BIOLOGY REPORTS
- Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling
- (2012) Ju-Hye Lee et al. APOPTOSIS
- Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo
- (2012) P. Rajendran et al. Cancer Prevention Research
- Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats
- (2012) Jun Zhang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Strong Inhibition of Celastrol Towards UDP-Glucuronosyl Transferase (UGT) 1A6 and 2B7 Indicating Potential Risk of UGT-Based Herb-Drug Interaction
- (2012) Yong-Sheng Zhang et al. MOLECULES
- Ursolic Acid Inhibits the Initiation, Progression of Prostate Cancer and Prolongs the Survival of TRAMP Mice by Modulating Pro-Inflammatory Pathways
- (2012) Muthu K. Shanmugam et al. PLoS One
- Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
- (2011) Srikumar M. Raja et al. CANCER BIOLOGY & THERAPY
- Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L
- (2010) Hong Zhu et al. CANCER LETTERS
- Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
- (2010) Radhamani Kannaiyan et al. CANCER LETTERS
- Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
- (2010) X. Pang et al. CANCER RESEARCH
- Toxic effects of celastrol on embryonic development of zebrafish (Danio rerio)
- (2010) Sifeng Wang et al. DRUG AND CHEMICAL TOXICOLOGY
- Celastrol Acts as a Potent Antimetastatic Agent Targeting 1 Integrin and Inhibiting Cell-Extracellular Matrix Adhesion, in Part via the p38 Mitogen-Activated Protein Kinase Pathway
- (2010) H. Zhu et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB
- (2010) Yao Dai et al. PLoS One
- Celastrol, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation
- (2009) Zhongzheng Lu et al. CANCER LETTERS
- Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
- (2008) Yulun Huang et al. CANCER LETTERS
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