Lack of Neuroprotective Effect of Celastrol Under Conditions of Proteasome Inhibition by Lactacystin in In Vitro and In Vivo Studies: Implications for Parkinson’s Disease

Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: Behavior, positron emission tomography, immunohistochemistry

(2013) Scott Mackey et al.   EXPERIMENTAL NEUROLOGY

The Extent of Neurodegeneration and Neuroprotection in Two Chemical In Vitro Models Related to Parkinson’s Disease is Critically Dependent on Cell Culture Conditions

(2013) D. Jantas et al.   NEUROTOXICITY RESEARCH

Celastrol Inhibits Lipopolysaccharide-Stimulated Rheumatoid Fibroblast-Like Synoviocyte Invasion through Suppression of TLR4/NF-κB-Mediated Matrix Metalloproteinase-9 Expression

(2013) Guoqing Li et al.   PLoS One

Parkinson’s disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

(2012) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Retinoic acid protects against proteasome inhibition associated cell death in SH-SY5Y cells via the AKT pathway

(2012) Benxu Cheng et al.   NEUROCHEMISTRY INTERNATIONAL

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

(2011) Srikumar M. Raja et al.   CANCER BIOLOGY & THERAPY

Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats

(2011) Elżbieta Lorenc-Koci et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons

(2011) D. Jantas et al.   NEUROTOXICOLOGY

Evolution of Extra-Nigral Damage Predicts Behavioural Deficits in a Rat Proteasome Inhibitor Model of Parkinson's Disease

(2011) Anthony C. Vernon et al.   PLoS One

Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells

(2010) Hongli Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells

(2010) Shantel E. Walcott et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

Proteasome inhibition modeling nigral neuron degeneration in Parkinson’s disease

(2010) Wenjie Xie et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotection of Pramipexole in UPS Impairment Induced Animal Model of Parkinson’s Disease

(2010) Chao Li et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

(2009) Katharina Faust et al.   BMC NEUROSCIENCE

Systemic Administration of Proteasome Inhibitor Protects Against MPTP Neurotoxicity in Mice

(2009) Takuya Oshikawa et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model

(2009) Dae Yong Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Nigral Degeneration with Inclusion Body Formation and Behavioral Changes in Rats after Proteasomal Inhibition

(2009) Chaoshi Niu et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism

(2008) Pamela Maher   BIOCHEMICAL PHARMACOLOGY

BV-2 stimulation by lactacystin results in a strong inflammatory reaction and apoptotic neuronal death in SH-SY5Y cells

(2008) Seon-Joo Kwon et al.   BRAIN RESEARCH

Proteasome Inhibitor Does Not Enhance MPTP Neurotoxicity in Mice

(2008) Naoto Kadoguchi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Therapeutic effect of tripterine on adjuvant arthritis in rats

(2008) Hong Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

c-Jun N-Terminal Kinase Mediates Lactacystin-Induced Dopamine Neuron Degeneration

(2008) Xuping Li et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY