Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability

Editorial: The Protein Alpha-Synuclein: Its Normal Role (in Neurons) and Its Role in Disease

(2020) Ruth G. Perez   Frontiers in Neuroscience

The VEGA suite of programs: an versatile platform for cheminformatics and drug design projects

(2020) Alessandro Pedretti et al.   BIOINFORMATICS

Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm

(2020) Samuel Peña-Díaz et al.   Frontiers in Bioengineering and Biotechnology

ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization

(2019) Samuel Peña-Díaz et al.   Frontiers in Molecular Neuroscience

The genetics of Parkinson disease

(2018) Hao Deng et al.   AGEING RESEARCH REVIEWS

Fast and accurate prediction of the regioselectivity of electrophilic aromatic substitution reactions

(2018) Jimmy C. Kromann et al.   Chemical Science

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

(2018) Jordi Pujols et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Evidence of the Parkinson Pandemic

(2018) E. Ray Dorsey et al.   Journal of Parkinsons Disease

High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors

(2017) Jordi Pujols et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Copper-Catalyzed N-Arylation of Nitroenamines with Diaryliodonium Salts

(2017) Klára Aradi et al.   JOURNAL OF ORGANIC CHEMISTRY

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Therapeutic approaches in Parkinson's disease and related disorders

(2016) Elvira Valera et al.   JOURNAL OF NEUROCHEMISTRY

Computational Methods to Predict the Regioselectivity of Electrophilic Aromatic Substitution Reactions of Heteroaromatic Systems

(2016) Monika Kruszyk et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Fungicidal Activity and Mode of Action of 4-Phenyl-6-trifluoromethyl-2-aminopyrimidines against Botrytis cinerea

(2016) Chunhui Liu et al.   MOLECULES

What Can the Kinetics of Amyloid Fibril Formation Tell about Off-pathway Aggregation?

(2015) Rosa Crespo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure

(2015) Zoran Rankovic   JOURNAL OF MEDICINAL CHEMISTRY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research

(2014) Haibin Liu et al.   Journal of Chemical Information and Modeling

Discovery of Novel Inhibitors of Amyloid β-Peptide 1–42 Aggregation

(2012) Laura C. López et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents againstHelicobacter pyloriInfection

(2009) Nunilo Cremades et al.   ACS Chemical Biology