ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization

In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies

(2019) Amir Tayaranian Marvian et al.   JOURNAL OF NEUROCHEMISTRY

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

(2019) Anita Carija et al.   Redox Biology

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells

(2019) Jianqun Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity

(2018) Hanna Kim et al.   MOLECULAR NEUROBIOLOGY

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

(2018) Jordi Pujols et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors

(2017) Jordi Pujols et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

(2016) Ricardo Sant'Anna et al.   Nature Communications

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease

(2016) Lars Tatenhorst et al.   Acta Neuropathologica Communications

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells

(2015) Ben Moree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What Can the Kinetics of Amyloid Fibril Formation Tell about Off-pathway Aggregation?

(2015) Rosa Crespo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein in Parkinson's disease: getting to the core of the matter

(2015) Robert A Hauser   LANCET NEUROLOGY

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset

(2014) Johannes Levin et al.   ACTA NEUROPATHOLOGICA

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)

(2014) Maria Eugenia Herva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases

(2013) Fernando Muñoz-Lobato et al.   ANTIOXIDANTS & REDOX SIGNALING

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease

(2012) A. J. Harrington et al.   JOURNAL OF NEUROSCIENCE

Protein misfolding cyclic amplification of infectious prions

(2012) Rodrigo Morales et al.   Nature Protocols

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra

(2010) Alison L. McCormack et al.   PLoS One

Fibril fragmentation in amyloid assembly and cytotoxicity

(2010) Wei-Feng Xue et al.   Prion

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics