In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes

Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients

(2021) Reza Ghanbari et al.   Future Microbiology

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

(2021) Fei Li et al.   Nature Communications

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

(2021) Sebastian Günther et al.   SCIENCE

Interaction of SZV 1287, a novel oxime analgesic drug candidate, and its metabolites with serum albumin

(2021) Eszter Fliszár-Nyúl et al.   JOURNAL OF MOLECULAR LIQUIDS

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

(2020) Markus Hoffmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment

(2020) Jing Sun et al.   CELL

Effects of chrysin and its major conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide on cytochrome P450 enzymes, and on OATP, P-gp, BCRP and MRP2 transporters

(2020) Violetta Mohos et al.   DRUG METABOLISM AND DISPOSITION

The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner

(2020) Mizuki Yamamoto et al.   Viruses-Basel

Pharmacokinetic interaction of diosmetin and silibinin with other drugs: Inhibition of CYP2C9-mediated biotransformation and displacement from serum albumin

(2018) Miklós Poór et al.   BIOMEDICINE & PHARMACOTHERAPY

HPLC–MS/MS analysis of mesupron and its application to a pharmacokinetic study in rats

(2018) Changmin Park et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

(2018) Dmitriy Sychev et al.   Drug Design Development and Therapy

Interactions of zearalenone and its reduced metabolites α-zearalenol and β-zearalenol with serum albumins: species differences, binding sites, and thermodynamics

(2018) Zelma Faisal et al.   Mycotoxin Research

Interactions of casticin, ipriflavone, and resveratrol with serum albumin and their inhibitory effects on CYP2C9 and CYP3A4 enzymes

(2018) Violetta Mohos et al.   BIOMEDICINE & PHARMACOTHERAPY

In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells

(2016) Erzsebet Pászti-Gere et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics

(2015) Wolfgang Garten et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Probing the interaction of cefodizime with human serum albumin using multi-spectroscopic and molecular docking techniques

(2015) Taoying Hu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice

(2014) C. Tarnow et al.   JOURNAL OF VIROLOGY

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

(2013) Daniela Meyer et al.   BIOCHEMICAL JOURNAL

Albumin–drug interaction and its clinical implication

(2013) Keishi Yamasaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

New 3-amidinophenylalanine-derived inhibitors of matriptase

(2012) Maya Hammami et al.   MedChemComm

Design and Synthesis of Potent, Selective Inhibitors of Matriptase

(2012) Éloïc Colombo et al.   ACS Medicinal Chemistry Letters

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Human serum albumin: From bench to bedside

(2011) Gabriella Fanali et al.   MOLECULAR ASPECTS OF MEDICINE

Type II transmembrane serine proteases in development and disease

(2007) R SZABO et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells

(2007) Eric C. Mossel et al.   VIROLOGY