Article
Pharmacology & Pharmacy
Sook Kwan Brown, Yeu-Yang Tseng, Ammar Aziz, Mariana Baz, Ian G. Barr
Summary: This study tested 3425 influenza B viruses collected from the Asia-Pacific region against four registered neuraminidase inhibitors (NAIs). It identified 45 influenza B viruses with reduced susceptibility to one or more NAIs, including some with newly identified neuraminidase mutations. The study highlights the potential impact of these mutations on the clinical effectiveness of NAIs in treating influenza B infections in humans.
ANTIVIRAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Mohamed Amine Jmel, Hajer Aounallah, Chaima Bensaoud, Imen Mekki, Jindrich Chmelar, Fernanda Faria, Youmna M'ghirbi, Michalis Kotsyfakis
Summary: Protease inhibitors are regulatory proteins found in all kingdoms that play crucial roles in controlling proteases, with potential applications in human disease treatment and agriculture. PIs from tick salivary glands have unique pharmacological properties and are promising candidates for drug development, progressing to preclinical and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Evgenii V. Matveev, Vyacheslav V. Safronov, Gennady V. Ponomarev, Marat D. Kazanov
Summary: The importance of 3D protein structure in proteolytic processing is well known. We developed a method that utilizes the structural features of potential substrates to predict proteolytic sites, taking into consideration factors such as solvent accessibility, secondary structure, and temperature factor. By carefully curating the training set, selecting an appropriate machine learning method, and determining the optimal positive-to-negative class size ratio, we demonstrated that our method outperforms existing bioinformatics methods for predicting proteolytic sites. This method may also have applications in predicting other post-translational modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Ping Li, Ruikun Du, Zinuo Chen, Yanyan Wang, Peng Zhan, Xinyong Liu, Dongwei Kang, Zhaoyu Chen, Xiujuan Zhao, Lin Wang, Lijun Rong, Qinghua Cui
Summary: Punicalagin from plants shows strong anti-influenza activity with a low micromolar IC(50)value. It primarily targets NA-mediated viral release, inhibits replication of different strains of influenza A and B viruses, including oseltamivir-resistant virus (NA/H274Y), and is a potential novel antiviral against influenza viruses.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Virology
Yucheng Zheng, Shiliang Li, Kun Song, Jiajie Ye, Wenkang Li, Yifan Zhong, Ziyan Feng, Simeng Liang, Zeng Cai, Ke Xu
Summary: Rapid development of broad-spectrum antiviral therapies is urgently needed for emerging and re-emerging viruses. Host-targeting antivirals that target universal host factors necessary for viral replication, such as dihydroorotate dehydrogenase (DHODH), show promise in inhibiting viral infection. DHODH inhibitors have demonstrated potential in inhibiting viral replication and suppressing cytokine storms.
Correction
Cell Biology
Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu
Summary: This article points out a few errors in Figure 1 of the original publication and provides the correct Figure 1.
Correction
Cell Biology
Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu
Summary: There were a few errors in Figure 1 in the original publication, and the correct Figure 1 is provided in this correction.
Article
Agriculture, Dairy & Animal Science
Piotr Dziechciarz, Aneta Strachecka, Krzysztof Olszewski
Summary: This study compared the activities of proteases and their inhibitors in the hemolymph of worker bees reared in small-cell and standard-cell combs, revealing significant differences in protein concentrations and enzyme activities based on the age group. These differences may be related to the tasks associated with different types of combs.
Article
Agronomy
Veronica Aparecida Faustino, Rafael de Almeida Barros, Neilier Rodrigues da Silva Junior, Samuel Lessa Barbosa, Camilo Elber Vital, Felipe Lopes da Silva, Yaremis Beatriz Merino Cabrera, Wellington Garcia Campos, Humberto Josue de Oliveira Ramos, Maria Goreti de Almeida Oliveira
Summary: Soybean plants exposed to drought stress show changes in their defense mechanisms related to protease inhibitors, affecting the survival and proteolytic activity of A. gemmatalis larvae feeding on them. The reduced survival of A. gemmatalis on drought-stressed plants is associated with the induced PIs activity and decreased protease levels in the midgut after herbivory.
Review
Virology
Vicky C. Roa-Linares, Manuela Escudero-Florez, Miguel Vicente-Manzanares, Juan C. Gallego-Gomez
Summary: The recent COVID-19 crisis has highlighted the importance of RNA-based viruses and the challenges they pose in terms of vaccination and treatment due to their high mutation capacity and ability to manipulate the host immune system.
Article
Entomology
Jose Cristian Vidal-Quist, Felix Ortego, Pedro Hernandez-Crespo
Summary: The study revealed that the activity in Dermatophagoides pteronyssinus is primarily dependent on cysteine proteases, particularly major allergen Der p 1, while both cysteine and serine proteases contribute similarly to fecal extracts. Additionally, the cysteine protease inhibitor cystatin A significantly reduced mite feeding and triggered overproduction of Der p 1.
JOURNAL OF INSECT PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kevin Ciminski, Geoffrey P. Chase, Martin Beer, Martin Schwemmle
Summary: Emergent IAV strains from animal hosts typically have poor adaptation to humans and cannot establish sustained transmission. Despite frequent exposure to endemic IAV in animal populations, the number of pandemics in humans remains surprisingly low.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Virology
Michihito Sasaki, Yukari Itakura, Mai Kishimoto, Koshiro Tabata, Kentaro Uemura, Naoto Ito, Makoto Sugiyama, Christida E. Wastika, Yasuko Orba, Hirofumi Sawa
Summary: This study identified host proteases TMPRSS2 and TMPRSS11D as mediators of trypsin-independent infection and growth of RVAs. These proteases promote the proteolytic activation of RVAs at the viral entry step, offering potential advantages for RVA research and development as an alternative to trypsin supplementation.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Beryl Mazel-Sanchez, Justyna Iwaszkiewicz, Joao P. P. Bonifacio, Filo Silva, Chengyue Niu, Shirin Strohmeier, Davide Eletto, Florian Krammer, Gene Tan, Vincent Zoete, Benjamin G. Hale, Mirco Schmolke
Summary: The excessive production of viral glycoproteins during infections can put a significant stress on the host cell's endoplasmic reticulum protein folding machinery. However, viruses have developed mechanisms to optimize this stress for their own replication by balancing folding capacity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Joseph D. Trimarco, Nicholas S. Heaton
Summary: Influenza viruses depend on and are affected by factors within the host cell. This relationship forms the basis for host-directed therapeutics, which target the host instead of the virus. Genetic screening has identified host factors that can modulate influenza virus infections, making them potential targets for host-directed antiviral strategies. However, there are currently no host-directed interventions for influenza viruses in clinical use.
CURRENT OPINION IN VIROLOGY
(2022)
Article
Cell Biology
Mohamed Kodiha, Nabila Azad, Siwei Chu, Noah Crampton, Ursula Stochaj
Summary: This study reveals that oxidative stress induces the nuclear accumulation of RanBP1 and the signaling pathways mediated by EGFR and PKA play a role in regulating RanBP1 localization during stress. RanBP1 acts as a downstream effector of these signaling routes, positioning it at the intersection of important cellular signaling circuits.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2024)