Intermolecular insights into allosteric inhibition of histone lysine-specific demethylase 1
出版年份 2021 全文链接
标题
Intermolecular insights into allosteric inhibition of histone lysine-specific demethylase 1
作者
关键词
LSD1, Allosteric inhibitor, MD simulations, QM/MM, Hirshfeld surface
出版物
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1865, Issue 11, Pages 129990
出版商
Elsevier BV
发表日期
2021-08-12
DOI
10.1016/j.bbagen.2021.129990
参考文献
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- (2020) Alessia Romussi et al. ACS Medicinal Chemistry Letters
- Carvedilol serves as a novel CYP1B1 inhibitor, a systematic drug repurposing approach through structure-based virtual screening and experimental verification
- (2020) Ying Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antiviral Properties of the LSD1 Inhibitor SP-2509
- (2020) Mitchell R. Harancher et al. JOURNAL OF VIROLOGY
- The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer
- (2020) Raffaella Soldi et al. PLoS One
- Synthesis, characterization, crystal structures, Hirshfeld surface analysis and DFT computational studies of new Schiff Bases derived from Phenylhydrazine
- (2020) Sakineh Parvarinezhad et al. JOURNAL OF MOLECULAR STRUCTURE
- Epigenetic drugs and their molecular targets in testicular germ cell tumours
- (2019) Sina Jostes et al. Nature Reviews Urology
- ZY0511, a novel, potent and selective LSD1 inhibitor, exhibits anticancer activity against solid tumors via the DDIT4/mTOR pathway
- (2019) Yan Li et al. CANCER LETTERS
- Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia
- (2019) Gauri Deb et al. LEUKEMIA
- LSD1/KDM1A inhibitors in clinical trials: advances and prospects
- (2019) Yuan Fang et al. Journal of Hematology & Oncology
- Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile
- (2018) Hideaki Niwa et al. MOLECULES
- LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
- (2018) Archana Sehrawat et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysine-Specific Demethylase 1A as a Promising Target in Acute Myeloid Leukemia
- (2018) Daniela Magliulo et al. Frontiers in Oncology
- Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors
- (2018) Qi-Sheng Ma et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration
- (2017) Luca Sartori et al. JOURNAL OF MEDICINAL CHEMISTRY
- Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure–Activity Relationship
- (2017) Paola Vianello et al. JOURNAL OF MEDICINAL CHEMISTRY
- Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1
- (2017) Daniel P. Mould et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen
- (2016) Yosuke Ota et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Quantitative relationships between structure and cytotoxic activity of flavonoid derivatives. An application of Hirshfeld surface derived descriptors
- (2016) Bogumiła Kupcewicz et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and biological evaluation of novel ( E )- N ′-(2,3-dihydro-1 H -inden-1-ylidene) benzohydrazides as potent LSD1 inhibitors
- (2016) Yang Zhou et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- LSD1 inhibitors: a patent review (2010-2015)
- (2016) Giulia Stazi et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent
- (2016) Paola Vianello et al. JOURNAL OF MEDICINAL CHEMISTRY
- CHARMM36m: an improved force field for folded and intrinsically disordered proteins
- (2016) Jing Huang et al. NATURE METHODS
- Relationship between LSD1 expression and E-cadherin expression in prostate cancer
- (2015) Min Wang et al. INTERNATIONAL UROLOGY AND NEPHROLOGY
- 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1
- (2015) Fangrui Wu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents
- (2015) Li-Ying Ma et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors
- (2015) Yi-Chao Zheng et al. MEDICINAL RESEARCH REVIEWS
- Computational Insight into p21-Activated Kinase 4 Inhibition: A Combined Ligand- and Structure-Based Approach
- (2014) Rui-Juan Li et al. ChemMedChem
- Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
- (2014) W Fiskus et al. LEUKEMIA
- Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration
- (2013) Yi-Chao Zheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- High-Throughput Virtual Screening Identifies Novel N′-(1-Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors
- (2013) Venkataswamy Sorna et al. JOURNAL OF MEDICINAL CHEMISTRY
- Performance of M06, M06-2X, and M06-HF Density Functionals for Conformationally Flexible Anionic Clusters: M06 Functionals Perform Better than B3LYP for a Model System with Dispersion and Ionic Hydrogen-Bonding Interactions
- (2013) Martin Walker et al. JOURNAL OF PHYSICAL CHEMISTRY A
- LSD1/CoREST Reversible Opening–Closing Dynamics: Discovery of a Nanoscale Clamp for Chromatin and Protein Binding
- (2012) Riccardo Baron et al. BIOCHEMISTRY
- Oncoepigenomics: Making histone lysine methylation count
- (2012) Daniel DeCarlo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1
- (2012) Stuart Hazeldine et al. JOURNAL OF MEDICINAL CHEMISTRY
- Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B
- (2011) Lu Wen et al. ACTA PHARMACOLOGICA SINICA
- Lysine Demethylases Inhibitors
- (2011) Takayoshi Suzuki et al. JOURNAL OF MEDICINAL CHEMISTRY
- Prediction of Absolute Solvation Free Energies using Molecular Dynamics Free Energy Perturbation and the OPLS Force Field
- (2010) Devleena Shivakumar et al. Journal of Chemical Theory and Computation
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