标题
Epigenetic drugs and their molecular targets in testicular germ cell tumours
作者
关键词
-
出版物
Nature Reviews Urology
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2019-02-14
DOI
10.1038/s41585-019-0154-x
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells
- (2018) Nam Hoang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses
- (2018) Daniela Matei et al. CLINICAL CANCER RESEARCH
- Therapeutic approaches for refractory germ cell cancer
- (2018) Christoph Oing et al. Expert Review of Anticancer Therapy
- The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML
- (2018) Daniel Gerlach et al. ONCOGENE
- Panobinostat and Multiple Myeloma in 2018
- (2018) Andrew J. Yee et al. ONCOLOGIST
- Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
- (2018) Jay H. Kalin et al. Nature Communications
- Integrated Molecular Characterization of Testicular Germ Cell Tumors
- (2018) Hui Shen et al. Cell Reports
- Abstract 1379: INCB059872, a novel FAD-directed LSD1 Inhibitor, is active in prostate cancer models and impacts prostate cancer stem-like cells
- (2018) Gianluca Civenni et al. CANCER RESEARCH
- Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment
- (2017) Ying-Chao Duan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Advances toward LSD1 inhibitors for cancer therapy
- (2017) Xiaoli Fu et al. Future Medicinal Chemistry
- Germ cell neoplasia in situ: The precursor cell for invasive germ cell tumors of the testis
- (2017) Cassy M. Spiller et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Procaine is a specific DNA methylation inhibitor with anti-tumor effect for human gastric cancer
- (2017) Yong-Chao Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial
- (2017) Hagop M Kantarjian et al. LANCET ONCOLOGY
- Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1
- (2017) Mathieu Gendarme et al. MOLECULAR BIOLOGY OF THE CELL
- Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation
- (2017) Martina Benešová et al. MOLECULAR CARCINOGENESIS
- All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis
- (2017) Dan Mei et al. PLoS One
- Current Management of Refractory Germ Cell Tumors and Future Directions
- (2017) J. Clayton Allen et al. Current Oncology Reports
- Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non–Small Cell Lung Cancer
- (2017) Dennis O. Adeegbe et al. Cancer Discovery
- Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis
- (2017) Saqer F. Alsaqer et al. Oncotarget
- A phase I, open-label, study of GSK2879552, a lysine-specific demethylase 1 (LSD1) inhibitor, in patients with relapsed/refractory small cell lung carcinoma (SCLC)
- (2016) V. Moreno et al. ANNALS OF ONCOLOGY
- IDH mutations in cancer and progress toward development of targeted therapeutics
- (2016) L. Dang et al. ANNALS OF ONCOLOGY
- All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy
- (2016) Yunwen Yan et al. BMC Complementary and Alternative Medicine
- Irreversible LSD1 Inhibitors: Application of Tranylcypromine and Its Derivatives in Cancer Treatment
- (2016) Yi C. Zheng et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia
- (2016) Amanda Przespolewski et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Role of TET enzymes in DNA methylation, development, and cancer
- (2016) Kasper Dindler Rasmussen et al. GENES & DEVELOPMENT
- Germ cell neoplasiain situ(GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy
- (2016) Daniel M Berney et al. HISTOPATHOLOGY
- The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins
- (2016) Yasushi Taniguchi INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo
- (2016) Sina Jostes et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors
- (2016) Aditya Bagrodia et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives
- (2016) Yongcheng Song et al. Journal of Hematology & Oncology
- Romidepsin for the treatment of relapsed/refractory peripheral T cell lymphoma: prolonged stable disease provides clinical benefits for patients in the pivotal trial
- (2016) Francine Foss et al. Journal of Hematology & Oncology
- Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075
- (2016) Emily J. Faivre et al. MOLECULAR CANCER RESEARCH
- Management of stage I testicular germ cell tumours
- (2016) Michal Chovanec et al. Nature Reviews Urology
- All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth
- (2016) P H Nguyen et al. ONCOGENE
- The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer
- (2016) L L da Motta et al. ONCOGENE
- HDACs and HDAC Inhibitors in Cancer Development and Therapy
- (2016) Yixuan Li et al. Cold Spring Harbor Perspectives in Medicine
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
- (2015) Michael Zengerle et al. ACS Chemical Biology
- Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells
- (2015) Isamu Hoshino et al. ANNALS OF SURGICAL ONCOLOGY
- Hypermethylation of genes in testicular embryonal carcinomas
- (2015) Hoi-Hung Cheung et al. BRITISH JOURNAL OF CANCER
- SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate
- (2015) Naoko Irie et al. CELL
- Phase I Population Pharmacokinetic Assessment of the Oral Bromodomain Inhibitor OTX015 in Patients with Haematologic Malignancies
- (2015) Elodie Odore et al. CLINICAL PHARMACOKINETICS
- The interplay of histone modifications - writers that read
- (2015) T. Zhang et al. EMBO REPORTS
- Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study
- (2015) Jean-Pierre J Issa et al. LANCET ONCOLOGY
- Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin
- (2015) Yuting Kuang et al. Molecular Oncology
- Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors
- (2015) Cassy M. Spiller et al. Molecular Oncology
- The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine
- (2015) Jean-Pierre Etchegaray et al. NATURE CELL BIOLOGY
- Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
- (2015) Pawel K Mazur et al. NATURE MEDICINE
- Induction of USP17 by combining BET and HDAC inhibitors in breast cancer cells
- (2015) Gabor Borbely et al. Oncotarget
- BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
- (2015) Emma K Baker et al. Scientific Reports
- BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma
- (2015) Daniel Nettersheim et al. PLoS Genetics
- Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective
- (2015) Alan Talevi Frontiers in Pharmacology
- Chromatin Remodelers: From Function to Dysfunction
- (2015) Gernot Längst et al. Genes
- BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
- (2015) Anton George Henssen et al. Oncotarget
- Long-term survival, prevalence, and cure of cancer: a population-based estimation for 818 902 Italian patients and 26 cancer types
- (2014) L. Dal Maso et al. ANNALS OF ONCOLOGY
- Comparative drug screening in NUT midline carcinoma
- (2014) A H Beesley et al. BRITISH JOURNAL OF CANCER
- The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer
- (2014) F. Fang et al. CLINICAL CANCER RESEARCH
- Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells
- (2014) Sergio Valente et al. JOURNAL OF MEDICINAL CHEMISTRY
- Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential
- (2014) Rod T Mitchell et al. MODERN PATHOLOGY
- Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
- (2014) Irfan A. Asangani et al. NATURE
- BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma
- (2014) Joydeep Bhadury et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
- (2014) E. Seto et al. Cold Spring Harbor Perspectives in Biology
- The chemosensitivity of testicular germ cell tumors
- (2014) Ioannis A. Voutsadakis CELLULAR ONCOLOGY
- A miR-199a/miR-214 Self-Regulatory Network via PSMD10, TP53 and DNMT1 in Testicular Germ Cell Tumor
- (2014) Bi-Feng Chen et al. Scientific Reports
- Cisplatin resistance in germ cell tumours: models and mechanisms
- (2014) C. Jacobsen et al. Andrology
- Testicular seminoma and non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
- (2013) J. Oldenburg et al. ANNALS OF ONCOLOGY
- Lysine-specific histone demethylase LSD1 and the dynamic control of chromatin
- (2013) Thomas Rudolph et al. BIOLOGICAL CHEMISTRY
- Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis
- (2013) D G Kristensen et al. BRITISH JOURNAL OF CANCER
- Super-Enhancers in the Control of Cell Identity and Disease
- (2013) Denes Hnisz et al. CELL
- Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma
- (2013) Z. Cheng et al. CLINICAL CANCER RESEARCH
- Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability
- (2013) Benjamin E. L. Lauffer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
- (2013) Olivier Mirguet et al. JOURNAL OF MEDICINAL CHEMISTRY
- A phase 2 study of belinostat (PXD101) in patients with relapsed or refractory acute myeloid leukemia or patients over the age of 60 with newly diagnosed acute myeloid leukemia: a California Cancer Consortium Study
- (2013) Mark H. Kirschbaum et al. LEUKEMIA & LYMPHOMA
- LSD1 Regulates Pluripotency of Embryonic Stem/Carcinoma Cells through Histone Deacetylase 1-Mediated Deacetylation of Histone H4 at Lysine 16
- (2013) F. Yin et al. MOLECULAR AND CELLULAR BIOLOGY
- TET enzymes, TDG and the dynamics of DNA demethylation
- (2013) Rahul M. Kohli et al. NATURE
- A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages
- (2013) Aliaksandra Radzisheuskaya et al. NATURE CELL BIOLOGY
- Analysis of TET Expression/Activity and 5mC Oxidation during Normal and Malignant Germ Cell Development
- (2013) Daniel Nettersheim et al. PLoS One
- Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy
- (2013) Metin Karahoca et al. Clinical Epigenetics
- Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas
- (2012) Mei Dong et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Cancer Epigenetics: From Mechanism to Therapy
- (2012) Mark A. Dawson et al. CELL
- Small-Molecule Inhibition of BRDT for Male Contraception
- (2012) Martin M. Matzuk et al. CELL
- Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation
- (2012) Bijesh K. Biswal et al. PLoS One
- Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
- (2012) W. W. Lockwood et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma
- (2011) M Brait et al. BRITISH JOURNAL OF CANCER
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
- (2011) J. Wang et al. CANCER RESEARCH
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- Regulation of chromatin by histone modifications
- (2011) Andrew J Bannister et al. CELL RESEARCH
- Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells
- (2011) Kian Peng Koh et al. Cell Stem Cell
- NANOG promoter methylation and expression correlation during normal and malignant human germ cell development
- (2011) Daniel Nettersheim et al. Epigenetics
- Bromodomains as therapeutic targets
- (2011) Susanne Muller et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression
- (2011) Daniel Nettersheim et al. GENES CHROMOSOMES & CANCER
- Molecular mechanisms of cisplatin resistance
- (2011) L Galluzzi et al. ONCOGENE
- Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
- (2011) Y.-F. He et al. SCIENCE
- Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway
- (2011) R Koster et al. Cell Death & Disease
- The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers
- (2010) Elodie E. Noel et al. AMERICAN JOURNAL OF PATHOLOGY
- Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer
- (2010) H H Cheung et al. BRITISH JOURNAL OF CANCER
- Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells
- (2010) K Almstrup et al. BRITISH JOURNAL OF CANCER
- REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions
- (2010) Irfan A. Qureshi et al. CELL CYCLE
- 5-azacytidine treatment reorganizes genomic histone modification patterns
- (2010) Vitalina M. Komashko et al. Epigenetics
- Histological evidence for the existence of germ cell tumor cells showing embryonal carcinoma morphology but lacking OCT4 expression and cisplatin sensitivity
- (2010) Thomas Mueller et al. HISTOCHEMISTRY AND CELL BIOLOGY
- Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer
- (2010) Roelof Koster et al. JOURNAL OF CLINICAL INVESTIGATION
- Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells
- (2010) D. Kuck et al. MOLECULAR CANCER THERAPEUTICS
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Depletion of Embryonic Stem Cell Signature by Histone Deacetylase Inhibitor in NCCIT Cells: Involvement of Nanog Suppression
- (2009) J. S. You et al. CANCER RESEARCH
- High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors
- (2009) M. J. Beyrouthy et al. CANCER RESEARCH
- JNJ-26481585, a Novel "Second-Generation" Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
- (2009) J. Arts et al. CLINICAL CANCER RESEARCH
- Microsatellite Instability, Mismatch Repair Deficiency, andBRAFMutation in Treatment-Resistant Germ Cell Tumors
- (2009) Friedemann Honecker et al. JOURNAL OF CLINICAL ONCOLOGY
- CpG Island Hypermethylation of Cell-Free Circulating Serum DNA in Patients With Testicular Cancer
- (2009) Jörg Ellinger et al. JOURNAL OF UROLOGY
- Testicular Cancer: A Prototypic Tumor of Young Adults
- (2009) Brandon Hayes-Lattin et al. SEMINARS IN ONCOLOGY
- Origin of pluripotent germ cell tumours: The role of microenvironment during embryonic development
- (2008) David Møbjerg Kristensen et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
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