Structural insights into piRNA biogenesis

Small non-coding RNAs in human cancer: function, clinical utility, and characterization

(2021) Zhao Zhang et al.   ONCOGENE

Structural basis for piRNA targeting

(2021) Todd A. Anzelon et al.   NATURE

Zucchini consensus motifs determine the mechanism of pre-piRNA production

(2020) Natsuko Izumi et al.   NATURE

The piRNA pathway in Drosophila ovarian germ and somatic cells

(2020) Kaoru SATO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Crystal structure of Drosophila Piwi

(2020) Sonomi Yamaguchi et al.   Nature Communications

The biogenesis and functions of piRNAs in human diseases

(2020) Xi Wu et al.   Molecular Therapy-Nucleic Acids

Structure-function analysis of microRNA 3′-end trimming by Nibbler

(2020) Wei Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1

(2019) Sizhuo Chen et al.   METHODS

PIWI pathway against viruses in insects

(2019) Anna Kolliopoulou et al.   Wiley Interdisciplinary Reviews-RNA

Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate

(2018) Zhongmin Liu et al.   CELL

Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain

(2018) Ling Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi

(2018) Yuhan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals

(2018) Ildar Gainetdinov et al.   MOLECULAR CELL

piRNA-Guided Genome Defense: From Biogenesis to Silencing

(2018) Benjamin Czech et al.   Annual Review of Genetics

PIWI-interacting RNAs: small RNAs with big functions

(2018) Deniz M. Ozata et al.   NATURE REVIEWS GENETICS

Poly(A)-specific ribonuclease sculpts the 3' ends of microRNAs

(2018) Dooyoung Lee et al.   RNA

Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2

(2017) Heng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dicer uses distinct modules for recognizing dsRNA termini

(2017) Niladri K. Sinha et al.   SCIENCE

PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice

(2017) Deqiang Ding et al.   Nature Communications

Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA

(2016) Naoki Matsumoto et al.   CELL

The RNase PARN-1 Trims piRNA 3′ Ends to Promote Transcriptome Surveillance in C. elegans

(2016) Wen Tang et al.   CELL

Identification and Functional Analysis of the Pre-piRNA 3′ Trimmer in Silkworms

(2016) Natsuko Izumi et al.   CELL

Genetic and mechanistic diversity of piRNA 3′-end formation

(2016) Rippei Hayashi et al.   NATURE

Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development

(2016) Dimitrios Anastasakis et al.   NUCLEIC ACIDS RESEARCH

PIWI-Interacting RNA: Its Biogenesis and Functions

(2015) Yuka W. Iwasaki et al.   Annual Review of Biochemistry

Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms

(2015) Wei Wang et al.   MOLECULAR CELL

piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis

(2015) F. Mohn et al.   SCIENCE

RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts

(2014) Jordi Xiol et al.   CELL

piRNAs: from biogenesis to function

(2014) E.-M. Weick et al.   DEVELOPMENT

A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer

(2014) Yuan Tian et al.   MOLECULAR CELL

Structural basis for microRNA targeting

(2014) N. T. Schirle et al.   SCIENCE

PIWI proteins and their interactors in piRNA biogenesis, germline development and gene expression

(2014) Hsueh-Yen Ku et al.   National Science Review

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline

(2013) Jonathan P Saxe et al.   EMBO JOURNAL

Untangling the web: The diverse functions of the PIWI/piRNA pathway

(2013) Sneha Ramesh Mani et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Substrate-specific structural rearrangements of human Dicer

(2013) David W Taylor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcriptional Silencing of Transposons by Piwi and Maelstrom and Its Impact on Chromatin State and Gene Expression

(2012) Grzegorz Sienski et al.   CELL

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

(2012) Hiroshi Nishimasu et al.   NATURE

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

(2012) Jonathan J. Ipsaro et al.   NATURE

Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc

(2012) F. Voigt et al.   RNA

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

(2011) Serena De Fazio et al.   NATURE

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

(2011) Michael Reuter et al.   NATURE

Deciphering arginine methylation: Tudor tells the tale

(2011) Chen Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The long and the short of noncoding RNAs

(2009) Christopher A Brosnan et al.   CURRENT OPINION IN CELL BIOLOGY

Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines

(2009) Kazumichi M Nishida et al.   EMBO JOURNAL

Structural insights into mechanisms of the small RNA methyltransferase HEN1

(2009) Ying Huang et al.   NATURE

Structural Basis of m7GpppG Binding to Poly(A)-Specific Ribonuclease

(2009) Mousheng Wu et al.   STRUCTURE

Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice

(2009) Alexei A. Aravin et al.   PLoS Genetics

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

Endogenous small interfering RNAs in animals

(2008) Katsutomo Okamura et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY