A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening

Detection of SARS-CoV-2 Viral Particles Using Direct, Reagent-Free Electrochemical Sensing

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Diagnostics for SARS-CoV-2 infections

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Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19

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Live-Cell Imaging of Survivin mRNA by Using a Dual-Color Surface-Cross-Linked Nanoquencher

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Mechanism of Cyanine5 to Cyanine3 Photoconversion and Its Application for High-Density Single-Particle Tracking in a Living Cell

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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

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A new coronavirus associated with human respiratory disease in China

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Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

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Structural and biochemical characterization of SADS‐CoV papain‐like protease 2

(2020) Lu Wang et al.   PROTEIN SCIENCE

Chemistry and Biology of SARS-CoV-2

(2020) Alexander Dömling et al.   Chem

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

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Nanotechnology-based disinfectants and sensors for SARS-CoV-2

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Allosteric Inhibition of the SARS‐CoV‐2 Main Protease: Insights from Mass Spectrometry Based Assays

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Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CLpro Reporter Assay

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SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

(2020) Wioletta Rut et al.   Nature Chemical Biology

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

(2020) Wioletta Rut et al.   Science Advances

AND-gate contrast agents for enhanced fluorescence-guided surgery

(2020) John C. Widen et al.   Nature Biomedical Engineering

A ligand selection strategy identifies chemical probes targeting the proteases of SARS‐CoV‐2

(2020) Lilian Peñalver et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simultaneous Dual‐Gene Diagnosis of SARS‐CoV‐2 Based on CRISPR/Cas9‐Mediated Lateral Flow Assay

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Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

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Spatial and temporal roles of SARS‐CoV PL pro —A snapshot

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A Multifunctional Peptide-Conjugated AIEgen for Efficient and Sequential Targeted Gene Delivery into the Nucleus

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Getting in: emerging methods and design principles for cell-penetrant peptides

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Peptide-based nanoprobes for molecular imaging and disease diagnostics

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Ensemble multicolour FRET model enables barcoding at extreme FRET levels

(2018) Milad Dagher et al.   Nature Nanotechnology

A FRET sensor enables quantitative measurements of membrane charges in live cells

(2017) Yuanqing Ma et al.   NATURE BIOTECHNOLOGY

Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells

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Protease-Responsive Prodrug with Aggregation-Induced Emission Probe for Controlled Drug Delivery and Drug Release Tracking in Living Cells

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Recent Development of Chemosensors Based on Cyanine Platforms

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An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

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A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range

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FRET-Based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5

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Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

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In vitro and ex vivo strategies for intracellular delivery

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Highly multiplexed simultaneous detection of RNAs and proteins in single cells

(2016) Andreas P Frei et al.   NATURE METHODS

SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity

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p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLprovia E3 ubiquitin ligase RCHY1

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The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

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Multifunctional fibers for simultaneous optical, electrical and chemical interrogation of neural circuits in vivo

(2015) Andres Canales et al.   NATURE BIOTECHNOLOGY

Single-band upconversion nanoprobes for multiplexed simultaneous in situ molecular mapping of cancer biomarkers

(2015) Lei Zhou et al.   Nature Communications

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo

(2014) Deju Ye et al.   Nature Chemistry

Semiconducting Polymer Nanoprobe for In Vivo Imaging of Reactive Oxygen and Nitrogen Species

(2013) Kanyi Pu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Three-Station DNA Catenane Rotary Motor with Controlled Directionality

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Fusion protein linkers: Property, design and functionality

(2012) Xiaoying Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Improving FRET dynamic range with bright green and red fluorescent proteins

(2012) Amy J Lam et al.   NATURE METHODS

Linkers in the structural biology of protein-protein interactions

(2012) Vishnu Priyanka Reddy Chichili et al.   PROTEIN SCIENCE

Strategies for in vivo imaging of enzyme activity: an overview and recent advances

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Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

(2011) Li-Zhi Mi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activatable Photosensitizers for Imaging and Therapy

(2010) Jonathan F. Lovell et al.   CHEMICAL REVIEWS

Photoswitchable fluorescent proteins enable monochromatic multilabel imaging and dual color fluorescence nanoscopy

(2008) Martin Andresen et al.   NATURE BIOTECHNOLOGY

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

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