Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan

Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs Versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice

(2020) Michael Walz et al.   Cells

Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations

(2020) Rachel S. Donocoff et al.   Scientific Reports

The effects of growth hormone on adipose tissue: old observations, new mechanisms

(2019) John J. Kopchick et al.   Nature Reviews Endocrinology

Effects of rapamycin on growth hormone receptor knockout mice

(2018) Yimin Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

(2018) Kai Mao et al.   Nature Communications

Standardizing protocols dealing with growth hormone receptor gene disruption in mice using the Cre-lox system

(2018) Silvana Duran-Ortiz et al.   GROWTH HORMONE & IGF RESEARCH

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

(2017) Nicole M. Templeman et al.   Cell Reports

Longevity is impacted by growth hormone action during early postnatal period

(2017) Liou Y Sun et al.   eLife

NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model

(2017) Nancy L. Nadon et al.   EBioMedicine

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan

(2017) Nicole M. Ashpole et al.   GeroScience

Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females

(2016) Riia K. Junnila et al.   ENDOCRINOLOGY

OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research

(2016) Seong Kyu Han et al.   Oncotarget

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

(2016) Michael B. Stout et al.   Aging-US

Growth hormone and aging: A challenging controversy

(2016) Andrzej Bartke   Clinical Interventions in Aging

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

(2015) Prasenjit Manna et al.   Metabolic Syndrome and Related Disorders

Long- But Not Short-Term Adult-Onset, Isolated GH Deficiency in Male Mice Leads to Deterioration of β-Cell Function, Which Cannot Be Accounted for by Changes in β-Cell Mass

(2014) Jose Cordoba-Chacon et al.   ENDOCRINOLOGY

Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles

(2014) Edward O. List et al.   ENDOCRINOLOGY

Diabetes and cancer: two diseases with obesity as a common risk factor

(2013) S. K. Garg et al.   DIABETES OBESITY & METABOLISM

The Relevance of Mouse Models for Investigating Age-Related Bone Loss in Humans

(2013) R. L. Jilka   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The GH/IGF-1 axis in ageing and longevity

(2013) Riia K. Junnila et al.   Nature Reviews Endocrinology

Metabolic Impact of Adult-Onset, Isolated, Growth Hormone Deficiency (AOiGHD) Due to Destruction of Pituitary Somatotropes

(2011) Raul M. Luque et al.   PLoS One

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Impact of short-term estrogen administration on growth hormone secretion and action: Distinct route-dependent effects on connective and bone tissue metabolism

(2010) Ken K.Y. Ho et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Biological effects of growth hormone on carbohydrate and lipid metabolism

(2009) Archana Vijayakumar et al.   GROWTH HORMONE & IGF RESEARCH

Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice

(2009) Y. Ikeno et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Two-Year Body Composition Analyses of Long-Lived GHR Null Mice

(2009) D. E. Berryman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA